Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

J Soerli; L Barfod; T Lavstsen; N L Bernasconi; A Lanzavecchia; L Hviid

doi:10.1111/j.1365-3024.2009.01097.x

Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

J Soerli, L Barfod, T Lavstsen, N L Bernasconi, A Lanzavecchia, L Hviid

12 Citations (Scopus)

Abstract

Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.

Original language	English
Journal	Parasite Immunology
Volume	31
Issue number	6
Pages (from-to)	341-6
Number of pages	5
ISSN	0141-9838
DOIs	https://doi.org/10.1111/j.1365-3024.2009.01097.x
Publication status	Published - 2009

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10.1111/j.1365-3024.2009.01097.x

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title = "Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens",

abstract = "Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.",

author = "J Soerli and L Barfod and T Lavstsen and Bernasconi, {N L} and A Lanzavecchia and L Hviid",

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doi = "10.1111/j.1365-3024.2009.01097.x",

language = "English",

volume = "31",

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T1 - Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

AU - Soerli, J

AU - Barfod, L

AU - Lavstsen, T

AU - Bernasconi, N L

AU - Lanzavecchia, A

AU - Hviid, L

PY - 2009

Y1 - 2009

N2 - Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.

AB - Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.

U2 - 10.1111/j.1365-3024.2009.01097.x

DO - 10.1111/j.1365-3024.2009.01097.x

M3 - Journal article

C2 - 19493213

SN - 0141-9838

VL - 31

SP - 341

EP - 346

JO - Parasite Immunology

JF - Parasite Immunology

IS - 6

ER -

Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

Abstract

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