Of mice and women: rodent models of placental malaria

Lars Hviid; Claudio R F Marinho; Trine Staalsoe; Carlos Penha-Gonçalves

doi:10.1016/j.pt.2010.04.010

Of mice and women: rodent models of placental malaria

Lars Hviid, Claudio R F Marinho, Trine Staalsoe, Carlos Penha-Gonçalves

26 Citations (Scopus)

Abstract

Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSA_PM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.

Original language	English
Journal	Trends in Parasitology
Volume	26
Issue number	8
Pages (from-to)	412-9
Number of pages	7
ISSN	1471-4922
DOIs	https://doi.org/10.1016/j.pt.2010.04.010
Publication status	Published - Aug 2010

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title = "Of mice and women: rodent models of placental malaria",

abstract = "Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.",

author = "Lars Hviid and Marinho, {Claudio R F} and Trine Staalsoe and Carlos Penha-Gon{\c c}alves",

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T1 - Of mice and women: rodent models of placental malaria

AU - Hviid, Lars

AU - Marinho, Claudio R F

AU - Staalsoe, Trine

AU - Penha-Gonçalves, Carlos

PY - 2010/8

Y1 - 2010/8

N2 - Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.

AB - Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.

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DO - 10.1016/j.pt.2010.04.010

M3 - Journal article

C2 - 20605743

SN - 1471-4922

VL - 26

SP - 412

EP - 419

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 8

ER -

Of mice and women: rodent models of placental malaria

Abstract

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