Department of Drug Design and Pharmacology

2005

Intra-operative remifentanil might influence pain levels in the immediate postoperative period after major abdominal surgery

Hansen, E., Duedahl, T. H., Rømsing, J. & Dahl, J. B., 2005, In: Acta Anaesthesiologica Scandinavica. 49, p. 1464-1470

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect

Duedahl, T. H., Dirks, J., Petersen, K., Rømsing, J., Larsen, N. E. & Dahl, J. B., 2005, In: Pain. 113, p. 360-368

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Is traditional medicine better off 25 years later?

Jäger, A., 22 Aug 2005, In: Journal of Ethnopharmacology. 100, 1-2, p. 3-4

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Kroppens egne cannabinoider påvirker immunsystemet

Degn, M., Hansen, H. S., Lund, T. M. & Petersen, G., 1 Jan 2005, In: Lægemiddelforskning. p. 8 9 p., 2.

Research output: Contribution to journal › Journal article › Research › peer-review

138 Downloads (Pure)

Membrane transport of anandamide through resealed human red blood cell membranes

Bojesen, I. N. & Hansen, H. S., 1 Aug 2005, In: Journal of Lipid Research. 46, 8, p. 1652-1659 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist

Ulven, T. & Kostenis, E., 2005, In: Journal of Medicinal Chemistry. 48, 4, p. 897-900 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators

Ritzén, A., Mathiesen, J. M. & Thomsen, C., 1 Oct 2005, In: Basic and Clinical Pharmacology and Toxicology. 97, 4, p. 202-213 12 p.

Research output: Contribution to journal › Short survey › peer-review

90 Citations (Scopus)

Morfin - nye aspekter ved 200 år gammel lægemiddelstof

Villesen, H., Jensen, N.-H., Hansen, S. H. & Christrup, L. L., 2005, In: Lægemiddelforskning. p. 30-31 2 p.

Research output: Contribution to journal › Journal article › Research

Muscarinic inhibition of spike-evoked calcium transients is mediated by an SNX sensitive "R-type" calcium channel in mouse mesopontine cholinergic neurons of the laterodorsal tegmental (LDT) nucleus

Kohlmeier, K. A. & Leonard, C., 2005.

Research output: Contribution to conference › Conference abstract for conference › Research

N-acyl phosphatidylethanolamines affect the lateral distribution of cholesterol in membranes

Térová, B., Slotte, J. P., Petersen, G. & Hansen, H. S., 30 Aug 2005, In: B B A - Biomembranes. 1715, 1, p. 49-56 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

N-Alkylation Reactions and Indirect Formation of Amino Functionalities in Solid-Phase Synthesis

Olsen, C. A., Jaroszewski, J. W. & Franzyk, H., 2005, In: Synthesis. p. 2631-2653 23 p.

Research output: Contribution to journal › Review › peer-review

30 Citations (Scopus)

Natural products as tools for studies of ligand-gated ion channels

Strømgaard, K., 2005, In: Chemical Record. 5, 4, p. 229-239 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre

Sjøgren, P., Christrup, L. L., Petersen, M. A. & Højsted, J., Aug 2005, In: European Journal of Pain. 9, 4, p. 453-62 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

92 Citations (Scopus)

Neuroscience: an intrusive chaperone

Kristensen, A. S. & Traynelis, S. F., 23 Jun 2005, In: Nature. 435, 7045, p. 1042-3 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Neuroscience: an intrusive chaperone

Kristensen, A. S., 23 Jun 2005, In: Nature. 435, 7045, p. 1042-1043 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

New Linker Strategies in SPS of Neuroactive Wasp Toxin Analogues

Olsen, C. A., Jaroszewski, J. W. & Franzyk, H., 2005.

Research output: Contribution to conference › Poster › Research

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain

Wellendorph, P., Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, B., Frølund, B., Brehm, L., Clausen, R. P. & Bräuner-Osborne, H., Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Occurence of N-acylethanolamines and their precursors in neuronal rafts

Petersen, G., Lund, T. M. & Hansen, H., 2005, In: Chemistry and Physics of Lipids. 136, 2, p. 106-107 2 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

On-resin Carboxy Group Activation of ω-Amino Acids in Solid-Phase Synthesis of Philanthotoxin Analogues

Jørgensen, M. R., Jaroszewski, J. W., Witt, M. & Franzyk, H., 2005, In: Synthesis. p. 2687-2694 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Orexin receptor actions in the reticular activating system: Lessons from receptor knock-outs.

Leonard, C. S., Kohlmeier, K. A., Kristensen, M. P., Tyler, C., Burlet, S., Grupke, S. L. & Kalogiannis, M., 2005.

Research output: Contribution to conference › Conference abstract for conference › Research

Phytochemical and pharmacological screening of Sterculiaceae species and isolation of antibacterial compounds

Reid, K., Jäger, A., Light, M., Mulholland, D. & Van Staden, J., 28 Feb 2005, In: Journal of Ethnopharmacology. 97, 2, p. 285-291

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Polyamine toxins: development of selective ligands for ionotropic receptors

Strømgaard, K., Jensen, L. S. & Vogensen, S. B., 1 Mar 2005, In: Toxicon. 45, 3, p. 249-254 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA_A antagonists: Synthesis, pharmacology, and molecular modeling

Frølund, B., Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, B., Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, P. & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABA_A Antagonists: Synthesis, Pharmacology, and Molecular Modeling

Frølund, B., Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, B., Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, P. & Liljefors, T., 2005, In: Journal of Medicinal Chemistry. 48, p. 427–439

Research output: Contribution to journal › Journal article › Research › peer-review

Preparation of phenyl benzoyl pyrazoles as CRTH2 receptor ligands

Ulven, T. (Inventor), Frimurer, T. (Inventor), Rist, O. (Inventor), Kostenis, E. (Inventor), Hoegberg, T. (Inventor), Receveur, J.-M. (Inventor) & Grimstrup, M. (Inventor), 2005, Patent No. WO 2005/115382 A1

Research output: Patent

Preparation of substituted thiazoleacetic acids as CRTH2 receptor ligands

Ulven, T. (Inventor), Frimurer, T. (Inventor), Rist, O. (Inventor), Kostenis, E. (Inventor), Hoegberg, T. (Inventor), Receveur, J.-M. (Inventor) & Grimstrup, M. (Inventor), 2005, Patent No. WO 2005/116001 A1

Research output: Patent

Quinazoline compounds and their use in MCH-related disease

Frimurer, T. M. (Inventor), Ulven, T. (Inventor), Högberg, T. (Inventor), Nørregaard, P. K. (Inventor), Little, P. B. (Inventor), Receveur, J.-M. (Inventor) & Grimstrup, M. (Inventor), 2005, Patent No. WO 2005/123714

Research output: Patent

Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review

Rømsing, J., Møiniche, S., Mathiesen, O. & Dahl, J. B., 2005, In: Acta Anaesthesiologica Scandinavica. 49, p. 133-142

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids

Meyer, U., Bisel, P., Bräuner-Osborne, H., Madsen, U., Höfner, G., Wanner, K. T. & Frahm, A. W., Feb 2005, In: Chirality. 17, 2, p. 99-107

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Screening of traditionally used Lebanese herbs for neurological activities

Salah, S. & Jäger, A., 10 Feb 2005, In: Journal of Ethnopharmacology. 97, 1, p. 145-149

Research output: Contribution to journal › Journal article › Research › peer-review

90 Citations (Scopus)

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues

Clausen, R. P., Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, B., Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, A. & Krogsgaard-Larsen, P., 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908

Research output: Contribution to journal › Journal article › Research › peer-review

81 Citations (Scopus)

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

Olsen, C. A., Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W. & Franzyk, H., 2005, In: Organic Letters. 7, 9, p. 1703-6 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2

Holm, M. M., Lunn, M.-L., Traynelis, S. F., Kastrup, J. S. J. & Egebjerg, J., 23 Aug 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12053-8 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Substituted thiazoleacetic acids as CRTH2 receptor ligands

Ulven, T. (Inventor), Frimurer, T. M. (Inventor), Rist, Ø. (Inventor), Kostenis, E. (Inventor), Högberg, T. (Inventor), Receveur, J.-M. (Inventor) & Grimstrup, M. (Inventor), 2005, Patent No. WO 2005/116001 A1

Research output: Patent

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

Conti, P., De Amici, M., Grazioso, G., Roda, G., Pinto, A., Hansen, K. B., Nielsen, B., Madsen, U., Bräuner-Osborne, H., Egebjerg, J., Vestri, V., Pellegrini-Giampietro, D. E., Sibille, P., Acher, F. C. & De Micheli, C., 6 Oct 2005, In: Journal of Medicinal Chemistry. 48, 20, p. 6315-25

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Synthesis and binding studies of 2-arylapomorphines

Søndergaard, K., Kristensen, J. L., Palner, M., Gillings, N., Knudsen, G. M., Roth, B. & Begtrup, M., 21 Nov 2005, In: Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)

Hrdlicka, P. J., Andersen, N. K., Jepsen, J. S., Hansen, F. G., Haselmann, K. F., Nielsen, C., Wengel, J. & Stenvang, J., 1 Apr 2005, In: Bioorganic & Medicinal Chemistry. 13, 7, p. 2597-621 25 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)

Hrdlicka, P. J., Jepsen, J. S., Wengel, J. & Stenvang, J., 2005, In: Nucleosides, nucleotides & nucleic acids. 24, 5-7, p. 397-400 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)

Hrdlicka, P. J., Jepsen, J. S., Nielsen, C., Wengel, J. & Stenvang, J., 15 Feb 2005, In: Bioorganic & Medicinal Chemistry. 13, 4, p. 1249-60 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations

Søndergaard, K., Kristensen, J. L., Gillings, N. & Begtrup, M., 14 Oct 2005, In: European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Synthesis of azaphenanthridines via anionic ring closure

Hansen, H. M., Lysén, M., Begtrup, M. & Kristensen, J. L., 17 Oct 2005, In: Tetrahedron. 61, 42, p. 9955-9960 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors

Conti, P., Grazioso, G., di Ventimiglia, S. J., Pinto, A., Roda, G., Madsen, U., Bräuner-Osborne, H., Nielsen, B., Costagli, C. & Galli, A., Jun 2005, In: Chemistry & Biodiversity. 2, 6, p. 748-57

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Synthesis of ortho substituted arylboronic esters by in situ trapping of unstable lithio intermediates: 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-YL)Benzoic acid ethyl ester: [Benzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-, ethyl ester]

Kristensen, J. L., Lysén, M., Vedsø, P. & Begtrup, M., 1 Jan 2005, In: Organic Syntheses. 81, p. 134-139 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides

Lysén, M., Kelleher, S., Begtrup, M. & Kristensen, J. L., 24 Jun 2005, In: Journal of Organic Chemistry. 70, 13, p. 5342-5343 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18 Sep Pak™ cartridge

Herth, M. M., Thorpe, M. R. & Ferrieri, R. A., 1 Apr 2005, In: Journal of Labelled Compounds and Radiopharmaceuticals. 48, 5, p. 379-386 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology

Frølund, B., Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, U., Nielsen, B., Bräuner-Osborne, H., Stensbøl, T. B. & Krogsgaard-Larsen, P., 15 Sept 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

The effect of cultivation and plant age on the pharmacological activity of Merwilla natalensis bulbs

Sparg, S., Jäger, A. & van Staden, J., Jun 2005, In: South African Journal of Botany. 71, 2, p. 191-196

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism

Jørgensen, M., Olsen, C. A., Mellor, I. R., Usherwood, P. N. R., Witt, M., Franzyk, H. & Jaroszewski, J. W., 2005, In: Journal of Medicinal Chemistry. 48, 1, p. 56-70 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish

Gloriam, D. E., Bjarnadóttir, T. K., Yan, Y.-L., Postlethwait, J. H., Schiöth, H. B. & Fredriksson, R., May 2005, In: Molecular Phylogenetics and Evolution. 35, 2, p. 470-82 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

81 Citations (Scopus)

Towards discovery-driven translational research in breast cancer

Celis, J. E., Moreira, J. M. A., Gromova, I., Cabezon, T., Ralfkiaer, U., Guldberg, P., Thor Straten, P., Mouridsen, H., Friis, E., Holm, D., Rank, F. & Gromov, P., 1 Jan 2005, In: FEBS Journal. 272, 1, p. 2-15 14 p.

Research output: Contribution to journal › Review › peer-review

48 Citations (Scopus)

Department of Drug Design and Pharmacology

Research output

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