Polyamine toxins: development of selective ligands for ionotropic receptors

TY - JOUR

T1 - Polyamine toxins

T2 - development of selective ligands for ionotropic receptors

AU - Strømgaard, Kristian

AU - Jensen, Lars S

AU - Vogensen, Stine B

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Polyamine toxins, isolated from spiders and wasps, have been used as pharmacological tools for the study of ionotropic receptors, but their use have so far been hampered by their lack of selectivity. In this mini-review, we describe how careful synthetic modification of native polyamine toxins have led to highly selective and potent new ligands for specific ionotropic receptors, particularly certain glutamate receptors subtypes, as well as nicotinic acetylcholine receptors. Moreover, the recent developments of synthetic methods, that have greatly facilitated the synthesis of polyamine toxins and their analogues are described.

AB - Polyamine toxins, isolated from spiders and wasps, have been used as pharmacological tools for the study of ionotropic receptors, but their use have so far been hampered by their lack of selectivity. In this mini-review, we describe how careful synthetic modification of native polyamine toxins have led to highly selective and potent new ligands for specific ionotropic receptors, particularly certain glutamate receptors subtypes, as well as nicotinic acetylcholine receptors. Moreover, the recent developments of synthetic methods, that have greatly facilitated the synthesis of polyamine toxins and their analogues are described.

KW - Animals

KW - Molecular Structure

KW - Nicotinic Antagonists

KW - Polyamines

KW - Receptors, AMPA

KW - Receptors, Nicotinic

KW - Spider Venoms

KW - Spiders

KW - Structure-Activity Relationship

KW - Wasp Venoms

KW - Wasps

U2 - 10.1016/j.toxicon.2004.11.013

DO - 10.1016/j.toxicon.2004.11.013

M3 - Journal article

C2 - 15683862

SN - 0041-0101

VL - 45

SP - 249

EP - 254

JO - Toxicon

JF - Toxicon

IS - 3

ER -