Research output per year
Research output per year
Personal profile
Primary fields of research
Ionotropic receptors for inhibitory amino acids (GABA, glycine) with emphasis on the relation to epilepsyCurrent research
Ionotropic receptors for inhibitory amino acids (GABA, glycine) with emphasis on the relation to epilepsy. The mechanism of activation of the receptors and structure-activity relationships of the ligands are studied in cultured neurons or in cell lines expressing recombinant wild type or mutant receptors using patch-clamp electrophysiology. Inhibition of neuronal activity is studied in vitro (electrophysiology in brain slices) and in vivo in the PTZ kindling model of epilepsy, where both the anticonvulsive and antiepileptogenic effects can be investigated. Using these metods, a current main theme of our research is to investigate whether selective ligands for extrasynaptic GABAA receptors are potential antiepileptic drugs.Teaching
General physiology. Neurophysiology and -pharmacology. Biological standardization. Pharmacodynamics. Ion channel kinetics.Keywords
- Former Faculty of Pharmaceutical Sciences
- electrophysiology
- GABA
- pharmacodynamics
- animal models
- synaptic transmission
- epilepsy
- ion channel kinetics
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- 6 Similar Profiles
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Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)
Leguizamon, C. R. R., Elnagar, M., Kristiansen, U. & Kohlmeier, K. A., 1 Dec 2019, In: Scientific Reports. p. 1 - 11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus)17 Downloads (Pure) -
The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice
von Schoubye, N. L., Frederiksen, K., Kristiansen, U., Petersen, A. V., Dalby, N. O., Grunnet, M., Jensen, H. S., Jespersen, T., Sohal, V. S. & Perrier, J-F., 1 Jan 2018, In: Neuroscience Letters. 662, p. 29-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells
Simonsen, C., Boddum, K., von Schoubye, N. L., Kloppenburg, A., Sønderskov, K., Hansen, S. L. & Kristiansen, U., Aug 2017, In: Pharmacology Research & Perspectives. 5, 4, 15 p., e00322.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic GABA transporter activity modulates excitatory neurotransmission
Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, U., Rusakov, D. A., Pavlov, I. & Walker, M. C., 25 Nov 2016, In: Nature Communications. 7, 10 p., 13572.Research output: Contribution to journal › Journal article › Research › peer-review
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Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors
Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, U., Frølund, B., Frederiksen, K. & Jensen, A. A., 15 Jun 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Uterine contraction induced by Ghanaian plants used to induce abortion
Larsen, B. HV., Soelberg, J., Kristiansen, U. & Jäger, A. K., 1 Sept 2016, In: South African Journal of Botany. 106, p. 137-39 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology
Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, P., Kristiansen, U. & Frølund, B., 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Vol. 72. p. 201-27 27 p. (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Hippocampal P3-Like Auditory Event-Related Potentials are Disrupted in a Rat Model of Cholinergic Degeneration in Alzheimer's Disease: Reversal by Donepezil Treatment: Reversal by Donepezil Treatment
Laursen, B., Mørk, A., Kristiansen, U. & Bastlund, J. F., 2 Jul 2014, In: Journal of Alzheimer's Disease. 42, 4, p. 1179–1189 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
- 1 Membership in research network
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Biologue (External organisation)
Uffe Kristiansen (Member)
10 May 2006 → …Activity: Membership types › Membership in research network