Susan Weng Larsen

2019

Citrem-phosphatidylcholine nano-self-assemblies: solubilization of bupivacaine and its role in triggering a colloidal transition from vesicles to cubosomes and hexosomes

Prajapati, R., Larsen, S. W. & Yaghmur, A., 21 Jul 2019, In: Physical Chemistry Chemical Physics. 21, 27, p. 15142-15150

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Transport characteristics in a novel in vitro release model for testing the performance of intra-articular injectables

Mertz, N., Ostergaard, J., Yaghmur, A. & Larsen, S. W., 20 Jul 2019, In: International Journal of Pharmaceutics. 566, p. 445-453

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2018

Concomitant monitoring of implant formation and drug release of in situ forming poly (lactide-co-glycolide acid) implants in a hydrogel matrix mimicking the subcutis using UV–vis imaging

Sun, Y., Jensen, H., Petersen, N. J., Larsen, S. W. & Østergaard, J., 20 Feb 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 150, p. 95-106

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

UV-vis Imaging of Piroxicam Supersaturation, Precipitation, and Dissolution in a Flow-Through Setup

Sun, Y., Chapman, A., Larsen, S. W., Jensen, H., Petersen, N. J., Goodall, D. M. & Ostergaard, J., 5 Jun 2018, In: Analytical Chemistry. 90, 11, p. 6413-6418

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

9 Downloads (Pure)

2017

Phase separation of in situ forming poly (lactide-co-glycolide acid) implants investigated using a hydrogel-based subcutaneous tissue surrogate and UV-vis imaging

Sun, Y., Jensen, H., Petersen, N. J., Larsen, S. W. & Østergaard, J., 25 Oct 2017, In: Journal of Pharmaceutical and Biomedical Analysis. 145, p. 682-691 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2016

Basic characteristics and kinetics of degradation in aqueous buffer of selected diclofenac prodrugs intended for joint injection

Mertz, N., Larsen, S. W. & Larsen, C. S., 6 Apr 2016. 1 p.

Research output: Contribution to conference › Poster › Research › peer-review

60 Downloads (Pure)

IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC

Larsen, C. S., Larsen, S. W., Thing, M. A., Kristensen, J. L., JENSEN, HENRIK. & ØSTERGAARD, JESPER., 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657

Research output: Patent

Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension

Mertz, N., Larsen, S. W., Kristensen, J., Østergaard, J. & Larsen, C., 1 Oct 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

PRODRUGS OF NAPROXEN AND DICLOFENAC

Larsen, C. S., Larsen, S. W., Thing, M. A., Kristensen, J. L., JENSEN, HENRIK. & ØSTERGAARD, JESPER., 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530

Research output: Patent

Role of Electrostatic Interactions on the Transport of Druglike Molecules in Hydrogel-Based Articular Cartilage Mimics: Implications for Drug Delivery

Ye, F., Baldursdottir, S., Hvidt, S., Jensen, H., Larsen, S. W., Yaghmur, A., Larsen, C. & Østergaard, J., 7 Mar 2016, In: Molecular Pharmaceutics. 13, 3, p. 819-28 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2014

A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection

Thing, M., Agårdh, L., Larsen, S., Rasmussen, R., Pallesen, J., Mertz, N., Kristensen, J. L., Hansen, M., Ostergaard, J. & Larsen, C. S., Dec 2014, In: Journal of Pharmaceutical Sciences. 103, 12, p. 4021–4029 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Drug formulations based on self-assembled liquid crystalline nanostructures

Yaghmur, A., Østergaard, J., Larsen, S. W., Jensen, H., Larsen, C. S. & Rappolt, M., 1 Jan 2014, Liposomes, lipid bilayers and model membranes: From basic research to application. Pabst, G., Kucerka, N., Nieh, M-P. & Katsaras, J. (eds.). Boca Raton: CRC Press, p. 341-360

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Mechanism of Action of Lung Damage Caused by a Nanofilm Spray Product

Larsen, S. T., Dallot, C., Larsen, S. W., Rose, F., Poulsen, S. S., Nørgaard, A. W., Hansen, J. S., Sørli, J. B., Nielsen, G. D. & Foged, C., 1 Aug 2014, In: Toxicological Sciences. 140, 2, p. 436-444 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Ostergaard, J., Jensen, H., Larsen, S. W., Larsen, C. & Lenke, J., Nov 2014, In: Journal of Pharmaceutical and Biomedical Analysis. 100, p. 290-293 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

PEGylation of Phytantriol-Based Lyotropic Liquid Crystalline Particles-The Effect of Lipid Composition, PEG Chain Length, and Temperature on the Internal Nanostructure

Nilsson, C., Ostergaard, J., Larsen, S. W., Larsen, C., Urtti, A. & Yaghmur, A., 10 Jun 2014, In: Langmuir : the ACS journal of surfaces and colloids. 30, 22, p. 6398-6407 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

2013

In situ forming drug delivery systems based on lyotropic liquid crystalline phases : structural characterization and release properties

Yaghmur, A., Rappolt, M. & Larsen, S. W., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 325-332

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Interaction of Amino Acid and Dipeptide beta-Naphthylamide Derivatives with Hyaluronic Acid and Human Serum Albumin Studied by Capillary Electrophoresis Frontal Analysis

Ye, F., Xie, Y., Jensen, H., Larsen, S. W., Yaghmur, A., Larsen, C. & Ostergaard, J., Jan 2013, In: Chromatographia. 76, 1-2, p. 49-57

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Medicindepot dannes efter injektion i leddet

Larsen, S. W., Thing, M. A., Østergaard, J., Kristensen, J. L., Hansen, M. & Larsen, C. S., 2013, In: Lægemiddelforskning. 2013, p. 38-40

Research output: Contribution to journal › Journal article › Research

Physicochemical profiling of drug candidates using capillary-based techniques

Jensen, H., Larsen, S. W., Larsen, C. S. & Østergaard, J., 2013, In: Journal of Drug Delivery Science and Technology. 23, p. 333-345

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

Larsen, C. S., Larsen, S. W., Thing, M. A., Kristensen, J. L., JENSEN, HENRIK. & OESTERGAARD, JESPER., 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591

Research output: Patent

Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat

Thing, M., Lu, Y., Agårdh, L., Larsen, C. S., Ostergaard, J., He, W., Wu, W., Larsen, F. & Larsen, S. W., 15 Jul 2013, In: International Journal of Pharmaceutics. 451, 1-2, p. 34-40 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

SPECT/CT imaging of radiolabeled cubosomes and hexosomes for potential theranostic applications

Nilsson, C., Barrios-Lopez, B., Kallinen, A., Laurinmäki, P., Butcher, S. J., Raki, M., Weisell, J., Bergström, K., Larsen, S. W., Ostergaard, J., Larsen, C., Urtti, A., Airaksinen, A. J. & Yaghmur, A., Nov 2013, In: Biomaterials. 34, 33, p. 8491-8503

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Use of in vitro release models in the design of sustained and localized drug delivery systems for subcutaneous and intra-articular administration

Larsen, S. W., Østergaard, J., Yaghmur, A., Jensen, H. & Larsen, C., 2013, In: Journal of Drug Delivery Science and Technology. 23, p. 333-345

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

2012

Characterization of bupivacaine-loaded formulations based on liquid crystalline phases and microemulsions: the effect of lipid composition

Yaghmur, A., Rappolt, M., Østergaard, J., Larsen, C. S. & Larsen, S. W., 7 Feb 2012, In: Langmuir. 28, 5, p. 2881-2889

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

Characterization of oil-free and oil-loaded liquid-crystalline particles stabilized by negatively charged stabilizer citrem

Nilsson, C., Edwards, K., Eriksson, J., Larsen, S. W., Østergaard, J., Larsen, C. S., Urtti, A. & Yaghmur, A., 14 Aug 2012, In: Langmuir. 28, 32, p. 11755-11766

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging

Ye, F., Larsen, S. W., Yaghmur, A., Jensen, H., Larsen, C. S. & Ostergaard, J., Dec 2012, In: Journal of Pharmaceutical and Biomedical Analysis. 71, p. 27-34 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

In vitro release from oil injectabels for intra-articular administration: importance of interfacial area, diffusivity and partitioning

Thing, M. A., Larsen, C. S., Østergaard, J., Jensen, H. & Larsen, S. W., 14 Feb 2012, In: European Journal of Pharmaceutical Sciences. 45, 3, p. 351-357

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Measurement of drug diffusivities in pharmaceutical solvents using Taylor dispersion analysis

Ye, F., Jensen, H., Larsen, S. W., Yaghmur, A., Larsen, C. S. & Østergaard, J., 5 Mar 2012, In: Journal of Pharmaceutical and Biomedical Analysis. 61, p. 176-183

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Modification of concomitant drug release from oil vehicles using drug-prodrug combinations to achieve sustained balanced analgesia after joint installation

Thing, M., Jensen, S. S., Larsen, C. S., Ostergaard, J. & Larsen, S. W., 15 Dec 2012, In: International Journal of Pharmaceutics. 439, 1-2, p. 246-53 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Real-time UV imaging of piroxicam diffusion and distribution from oil solutions into gels mimicking the subcutaneous matrix

Ye, F., Larsen, S. W., Yaghmur, A., Jensen, H., Larsen, C. S. & Østergaard, J., 12 May 2012, In: European Journal of Pharmaceutical Sciences. 46, 1-2, p. 72-78

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

2011

In situ characterization of lipidic bupivacaine-loaded formulations

Yaghmur, A., Larsen, S. W., Schmitt, M., Østergaard, J., Larsen, C. S., Jensen, H., Urtti, A. & Rappolt, M., 21 Sept 2011, In: Soft Matter. 7, p. 8291-8295

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Intra-articular injection of morphine to the horse: Establishment of an in vitro-in vivo relationship

Frost, A. B., Lindegaard, C., Larsen, F., Østergaard, J., Larsen, S. W. & Larsen, C. S., Sept 2011, In: Drug Development and Industrial Pharmacy. 37, 9, p. 1043-1048

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration

Larsen, S. W., Frost, A. B., Østergaard, J., Thomsen, M. H., Jacobsen, S., Skonberg, C., Hansen, S. H., Jensen, H. M. E. & Larsen, C. S., Oct 2011, In: Journal of Pharmaceutical Sciences. 100, 10, p. 4330-4337 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

Ostergaard, J., Ye, F., Rantanen, J., Yaghmur, A., Larsen, S. W., Larsen, C. S. & Jensen, H., Aug 2011, In: Journal of Pharmaceutical Sciences. 100, 8, p. 3405-3410

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration

Pedersen, B. T., Østergaard, J., Larsen, S. W., Cornett, C., Ankersen, M. & Larsen, C. S., Jan 2011, In: Drug Development and Industrial Pharmacy. 37, 1, p. 62-71

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Real-time UV imaging of drug diffusion and release from Pluronic F127 hydrogels

Ye, F., Yaghmur, A., Jensen, H., Larsen, S. W., Larsen, C. & Ostergaard, J., 17 Jul 2011, In: European Journal of Pharmaceutical Sciences. 43, 4, p. 236-243

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

2010

On the search for in vitro in vivo correlations in the field of intra-articular drug delivery: Administration of sodium diatrizoate to the horse

Frost, A. B., Larsen, F., Østergaard, J., Larsen, S. W., Lindegaard, C., Hansen, H. R. & Larsen, C. S., 11 Sept 2010, In: European Journal of Pharmaceutical Sciences. 41, p. 10-15

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Real-time UV imaging of nicotin release from transdermal patch

Østergaard, J., Meng-Lund, E., Larsen, S. W., Larsen, C. S., Petersson, K., Lenke, J. & Jensen, H., Dec 2010, In: Pharmaceutical Research. 27, p. 2614-2623

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

The pharmacokinetics of the weakly protein-bound anionic compound diatrizoate in serum and synovial fluid of the horse

Frost, A. B., Larsen, F., Larsen, S. W., Østergaard, J., Thomsen, M. H., Stürup, S., Andersen, P. H. & Larsen, C. S., Jan 2010, In: Pharmaceutical Research. 27, 1, p. 143-150 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

UV-imaging visulaliserer frigivelse af lægemiddelstoffer

Ye, F., Meng-Lund, E., Yaghmur, A., Larsen, S. W., Jensen, H., Larsen, C. S. & Østergaard, J., 2010, In: Lægemiddelforskning. 2010, p. 46-48

Research output: Contribution to journal › Journal article › Communication

2009

Binding of low-molecular-weight cationic ligands to chondroitin sulfate as studied by capillary electrophoresis frontal analysis

Østergaard, J., Jensen, H., Larsen, S. W., Larsen, C. R. & Larsen, C. S., 2009, In: Open Analytical Chemistry Journal. 3, p. 16-21

Research output: Contribution to journal › Journal article › Research › peer-review

Critical factors influencing the In Vivo performance of long-acting liophilic solutions - impact on In Vitro release method design

Larsen, S. W. & Larsen, C. S., 2009, In: The AAPS Journal. 11, 4, p. 762-770

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

In situ formed suspensions for local sustained action of celecoxib following intra-articular administration

Larsen, S. W., Frost, A. B., Østergaard, J., Jacobsen, S., Thomsen, M. H., Lindegaard, C., Andersen, P. H. & Larsen, C. S., 2009. 2 p.

Research output: Contribution to conference › Poster › Research

Role of in vitro release models in formulation development and quality control of parenteral depots

Larsen, C. S., Larsen, S. W., Jensen, H., Yaghmur, A. & Østergaard, J., 2009, In: Expert Opinion on Drug Delivery. 6, 12, p. 1283-1295

Research output: Contribution to journal › Review

62 Citations (Scopus)

Role of in vitro release models in formulation development and quality control of parenteral depots

Larsen, C., Larsen, S. W., Yaghmur, A., Ostergaard, J. & Jensen, H., Dec 2009, In: Expert Opinion on Drug Delivery. 6, 12, p. 1283-1295

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

2008

Assessment of drug release from oil depot formulations using an in vitro model: Potential applicability in accelerated release testing

Larsen, S. W., Jessen, M. N. B., Østergaard, J. & Larsen, C. S., 2008, In: Drug Development and Industrial Pharmacy. 34, 3, p. 297-304

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Drug - liposome distribution phenomena studied by capillary electrophoresis-frontal analysis

Østergaard, J., Jørgensen, L., Thomsen, A. E., Larsen, S. W., Larsen, C. S. & Jensen, H., 2008, In: Electrophoresis. 29, 16, p. 3320 - 3324

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders

Larsen, C. S., Østergaard, J., Larsen, S. W., Jensen, H., Jacobsen, S., Lindegaard, C. & Andersen, P. H., 2008, In: Journal of Pharmaceutical Sciences. 97, 11, p. 4622-4654 33 p.

Research output: Contribution to journal › Journal article › Research › peer-review

164 Citations (Scopus)

Intra-articular drug disapperance kinetics: Reducing the number of in vivo experiments from establishment of an in vitro-in vivo correlation?

Frost, A. B., Jacobsen, S., Thomsen, M. H., Lindegaard, C., Larsen, S. W., Østergaard, J., Andersen, P. H. & Larsen, C. S., 2008. 1 p.

Research output: Contribution to conference › Poster › Research

In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration

Pedersen, B. T., Larsen, S. W., Østergaard, J. & Larsen, C. S., 2008, In: Drug Delivery. 15, 1, p. 23-30

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Susan Weng Larsen

Research output

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