In situ characterization of lipidic bupivacaine-loaded formulations

Anan Yaghmur; Susan Weng Larsen; Mechthild Schmitt; Jesper Østergaard; Claus Selch Larsen; Henrik Jensen; Arto Urtti; Michael  Rappolt

doi:10.1039/c1sm05854a

In situ characterization of lipidic bupivacaine-loaded formulations

Anan Yaghmur, Susan Weng Larsen, Mechthild Schmitt, Jesper Østergaard, Claus Selch Larsen, Henrik Jensen, Arto Urtti, Michael Rappolt

35 Citations (Scopus)

Abstract

This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L ₂ and H ₂ phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.

Original language	English
Journal	Soft Matter
Volume	7
Pages (from-to)	8291-8295
ISSN	1744-683X
DOIs	https://doi.org/10.1039/c1sm05854a
Publication status	Published - 21 Sept 2011

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Former Faculty of Pharmaceutical Sciences

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10.1039/c1sm05854a

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title = "In situ characterization of lipidic bupivacaine-loaded formulations",

abstract = "This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L 2 and H 2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Anan Yaghmur and Larsen, {Susan Weng} and Mechthild Schmitt and Jesper {\O}stergaard and Larsen, {Claus Selch} and Henrik Jensen and Arto Urtti and Michael Rappolt",

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AU - Yaghmur, Anan

AU - Larsen, Susan Weng

AU - Schmitt, Mechthild

AU - Østergaard, Jesper

AU - Larsen, Claus Selch

AU - Jensen, Henrik

AU - Urtti, Arto

AU - Rappolt, Michael

PY - 2011/9/21

Y1 - 2011/9/21

N2 - This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L 2 and H 2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.

AB - This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L 2 and H 2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1039/c1sm05854a

DO - 10.1039/c1sm05854a

M3 - Journal article

SN - 1744-683X

VL - 7

SP - 8291

EP - 8295

JO - Soft Matter

JF - Soft Matter

ER -

In situ characterization of lipidic bupivacaine-loaded formulations

Abstract

Keywords

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