Real-time UV imaging of nicotin release from transdermal patch

Jesper Østergaard; Emil Meng-Lund; Susan Weng Larsen; Claus Selch Larsen; Karsten Petersson; James Lenke; Henrik Jensen

doi:10.1007/s11095-010-0257-9

Real-time UV imaging of nicotin release from transdermal patch

Jesper Østergaard, Emil Meng-Lund, Susan Weng Larsen, Claus Selch Larsen, Karsten Petersson, James Lenke, Henrik Jensen

69 Citations (Scopus)

Abstract

PURPOSE:
This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.
METHODS:
The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.
RESULTS:
Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.
CONCLUSION:
Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

Original language	English
Journal	Pharmaceutical Research
Volume	27
Pages (from-to)	2614-2623
ISSN	0724-8741
DOIs	https://doi.org/10.1007/s11095-010-0257-9
Publication status	Published - Dec 2010

Keywords

Former Faculty of Pharmaceutical Sciences

Access to Document

10.1007/s11095-010-0257-9

Cite this

@article{c86256fa73ea47048572bcee0995981d,

title = "Real-time UV imaging of nicotin release from transdermal patch",

abstract = "PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette{\textregistered} nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette{\textregistered}) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Jesper {\O}stergaard and Emil Meng-Lund and Larsen, {Susan Weng} and Larsen, {Claus Selch} and Karsten Petersson and James Lenke and Henrik Jensen",

year = "2010",

month = dec,

doi = "10.1007/s11095-010-0257-9",

language = "English",

volume = "27",

pages = "2614--2623",

journal = "Pharmaceutical Research",

issn = "0724-8741",

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TY - JOUR

T1 - Real-time UV imaging of nicotin release from transdermal patch

AU - Østergaard, Jesper

AU - Meng-Lund, Emil

AU - Larsen, Susan Weng

AU - Larsen, Claus Selch

AU - Petersson, Karsten

AU - Lenke, James

AU - Jensen, Henrik

PY - 2010/12

Y1 - 2010/12

N2 - PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

AB - PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s11095-010-0257-9

DO - 10.1007/s11095-010-0257-9

M3 - Journal article

C2 - 20811931

SN - 0724-8741

VL - 27

SP - 2614

EP - 2623

JO - Pharmaceutical Research

JF - Pharmaceutical Research

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