Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Jesper Ostergaard; Henrik Jensen; Susan W Larsen; Claus Larsen; Jim Lenke

doi:10.1016/j.jpba.2014.08.014

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Jesper Ostergaard, Henrik Jensen, Susan W Larsen, Claus Larsen, Jim Lenke

12 Citations (Scopus)

Abstract

Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.

Original language	English
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	100
Pages (from-to)	290-293
Number of pages	4
ISSN	0731-7085
DOIs	https://doi.org/10.1016/j.jpba.2014.08.014
Publication status	Published - Nov 2014

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title = "Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging",

abstract = "Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.",

author = "Jesper Ostergaard and Henrik Jensen and Larsen, {Susan W} and Claus Larsen and Jim Lenke",

year = "2014",

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doi = "10.1016/j.jpba.2014.08.014",

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T1 - Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

AU - Ostergaard, Jesper

AU - Jensen, Henrik

AU - Larsen, Susan W

AU - Larsen, Claus

AU - Lenke, Jim

PY - 2014/11

Y1 - 2014/11

N2 - Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.

AB - Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.

U2 - 10.1016/j.jpba.2014.08.014

DO - 10.1016/j.jpba.2014.08.014

M3 - Journal article

C2 - 25194341

SN - 0731-7085

VL - 100

SP - 290

EP - 293

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

ER -

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Abstract

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