Casper Lindegaard

CV

Curriculum Vitae

CASPER LINDEGAARD

PERSONAL DETAILS

Mailing Address

University of Copenhagen

Faculty of Life Sciences

Dept. Large Animal Sciences, Large Animal Surgery

Højbakkegård Allé 5, Bygning 8.68

DK-2630 Taastrup, Copenhagen

Denmark

E-mail: [email protected]

D.O.B. 07-03-1973

Nationality Danish

EDUCATION:

PhD degree within the field of Large Animal Clinical Sciences; 2009, Faculty of Life Sciences, University of Copenhagen, Denmark

Doctor of Veterinary Medicine (DVM); January 2002, Den Kongelige Veterinær og Landbohøjskole, KVL (Royal Veterinary and Agricultural University - now Faculty of Life Sciences, University of Copenhagen), Copenhagen, Denmark

PROFESSIONAL ACTIVITIES:

Post graduate employment

August 1^st 2008 -

Resident of Large Animal Surgery at the Large Animal Teaching Hospital, University of Copenhagen (standard training programme within the European College of Veterinary Surgeons (ECVS))

February 1^st 2007 - February 29^th 2008

Scientific assistant and equine surgeon at University of Copenhagen, Faculty of Life Sciences, Department of Large Animal Sciences. This job includes clinical research, clinical teaching (equine surgery) to veterinary students and being a part of the large animal surgical team, including off-hours surgical duties. Since November 1^st 2007 daily leader of anaesthesia at the Large Animal Hospital, University of Copenhagen

March 1^st 2005- January 31^st  2008 and March 1^st - July 31^st 2008

Ph.D. scholarship "Pain management in large animals" at the Department of Large Animal Sciences, Large Animal Surgery, Royal Veterinary and Agricultural University (KVL), Copenhagen, Denmark.

During the last 1 ½ year I've been working on my Ph.D.project which have the working title "Potential analgesic and anti inflammatory effects of intra-articularly administered morphine".

I'm very dedicated in the field of improving pain management in our patients. Which indeed includes better recognition of animal pain and one of the "by-products" of my Ph.D. research should be an improvement of pain scoring in equine orthopedic patients.

Within the Ph.D. scholarship I have participated in full time fulltime clinical/surgical work in the Large Animal Hospital of KVL, approximately 1 month / semester. This includes being a part of the team running the Large Animal clinic, as well as teaching undergraduate veterinary students, and giving lectures for veterinary students, and farrier trainees. The surgical work includes performing or assisting a variety of surgeries, mainly equine colic cases.

During this period I've also pursued one of my second interests; equine ophthalmology, ophthalmic surgery and ultrasonographic examination of the equine eye. 

June 1^st 2003 -February 28^th 2005                                

Internship, Large Animal Hospital, Department of Large Animal Sciences, Royal Veterinary and Agricultural University, Copenhagen, Denmark.

During this period I was on a rota between day, night and weekend within the Large Animal Hospital of KVL. During day shifts I always worked within the Surgical department of the Large Animal Hospital, which included 1^st opinion on referred cases, treatment of patients in the clinic, performing and assisting a wide variety of surgical procedures in mainly equine, but also bovine patients, and instructing undergraduate veterinary students. Furthermore the position included responsibility for client/owner contact and contact to the referring veterinarians. During night and weekend duty the position also included outpractice (80% equine), on non referred cases, as well as treatment of all types of patients within the Large Animal Hospital.

February 18^th 2002 - May 31^st 2003

Assistant veterinary surgeon. Als Dyrlæger, Alsia Dyrehospital, Keglen 2, DK-6440 Augustenborg, Denmark.

A five-vet rural mixed private practice in the southern part of Denmark. My workload consisted of 50% equine, 30% bovine and 20% small animals.

License to practice in Denmark issued February 2002

License to practice in Sweden issued July 2005

Others

August 1^st 1993 - May 31^st 1994

Teacher in a boarding school (8^th -10^th grade). My main assignment was to instruct the students in horse riding and handling, but I also functioned as a substitute in mathematics, Danish and French.

August 1^st 1992 - July 31^st 1993

Military service with the Royal Danish Horse Guard.

CONTINUING EDUCATION:

10^th  World congress of Veterinary Anesthesia, August 31^st - September 4^th, 2009, Glasgow, Scotland

18^th Annual Scientific Meeting of the European College of Veterinary Surgeons, July 2^nd - 4^th, Nantes, France

Training in Equine Anaesthesia, The Phillip Leverhulme Equine Hospital, Leahurst, University of Liverpool, UK, March 23- April 3, 2009.

CPD day for the Practicing Veterinarian, The Phillip Leverhulme Equine Hospital, Leahurst, University of Liverpool, UK, March 26, 2009.

Basic Principles of Fracture Management in Horses (AO-Course), Oberdorf, Switzerland, February 11-13, 2009.

Annual meeting of the Danish Equine Veterinarian Ass., Middelfart, Denmark, October 31-November 2, 2008.

Annual symposium of the ACVS 2008, San Diego, California, USA, October 23-26, 2007 (Including "Advanced Equine Laser Surgery Lab (Kenneth Sullins)).

Annual European Equine Basic Arthroscopy Course, Muenster, Germany, May 23-24, 2008

Nordic Equine Medicine Organization, Annual Meeting 2008 - "Equine Colic", Helsinki, Finland, March 28-30

Annual symposium of the ACVS 2007, Chicago, Illinois, USA, October 17-21, 2007.

"Equine Radiology", CPD at the Royal Veterinary College, University of London, July 18-20, 2007, RVC, London, UK

"Intraocular Surgery for Advanced Surgeons." Acri.Tec., February 23-25, 2007, Berlin, Germany

9^th  World congress of Veterinary Anesthesia and 4^th annual meeting of the International Veterinary Association of Pain Management, September 12^th -16^th, 2006, Santos, Brazil.

"Statistics for Veterinarians", Ph.D.-course (9 ECTS), RVAU, Copenhagen, Denmark, May-June 2006

Danish Opioid Science Centre 2006, (International conference on the use of opioids) April 27^th -28^th, Helsingor, Denmark, April 2006.

 "Research Methodology, Planning of Controlled Clinical Trials (CCT), Basic and Laboratory research (BLR) and Epidemiological Studies (ES)", NOVA Post graduate course (6 ECTS), NOVA University, Denmark and Norway, March-April, 2006.

"Equine Anesthesia", (2 ECTS), NOVA University, Internet-based, January - February 2006.

"Laboratory Animal Science", (9 ECTS), RVAU, Copenhagen, Denmark. This course gives the opportunity to obtain a license for animal experiments in Denmark, October-November 2005.

"Surgical day", internal eduction, RVAU, 1 day, 2004.

"Ultrasonography day", internal education, RVAU, 1 day, 2005.

"Anesthesia, analgesia and euthanasia of laboratory animals", Master class course in laboratory animal science (4 ECTS), RVAU, Copenhagen, Denmark. April 2005.

Merial Animal Health Pain Management Symposium, Innsbruck, Austria, January 27^th . - 30^th, 2005.

Maastricht International Congress of Equine Medicine (MICEM), Maastricht, the Netherlands, December 10^th-11^th 2004.

 "Treatment of tendonitis with stem cells", Minisymposium. Provided by Vetcell at Ansager Animal Hospital, Denmark, November 2004.

Annual meeting of the Danish Equine Veterinary Assosiation, 2003, Copenhagen, Denmark (3 days).

"Equine Wound Management & Equine Dermatology", Derek Knottenbelt in cooperation with Kruuse, Odense, Denmark (1 day), 2003.

"Equine orthopedics", modules 2, 3 and 4. Courses held by the Danish Veterinary Assosiation, Copenhagen, Denmark (total 5 days), 2002-2003.

"Equine Dentistry & Advanced equine Dentistry", Jack Easly in cooperation with Kruuse, Copenhagen, Denmark (2 days), 2003.

"Equine Herpes virus infection", Intervet, Copenhagen, Denmark (1 day), 2002.

Annual meeting of the Danish Equine Veterinary Assosiation, 2001, Helsingor, Denmark (3 days).

SCIENTIFIC ORGANISATIONS:

International Veterinary Association of Pain Management, since 2005

HONOURS:

KVL Ph.D. scholarship with tuition and salary, 2005, approximately DKK 1.5 million.

Research grants, awarded for the Ph.D. project.

"Kustos Grant", 2006, DKK 50,000.

"The Vetfond Grant", 2005, DKK 12,500.

"Intervet Denmark's grant for young veterinary scientists", 2005, DKK 9000.

OFFICES HELD:

1996-1998

Member of the competition organising committee of Kongelundens Rideklub (Local Riding club), Amager, Denmark

1994-1996

Board member Glamsbjerg Rideklub (Local Riding club), Glamsbjerg, Denmark.

1990-1996

Member of the competition organising committee of Glamsbjerg Rideklub (Local Ridingclub), Glamsbjerg, Denmark.

PROFESSIONAL PRESENTATIONS:

"Pain Evaluation in Horses", Invited oral presentation at CPD course for Equine Practitioners, arranged by Boehringer-Ingelheim Scandinavia, Copenhagen, Denmark, October 15, 2009.

„Pharmacokinetics of intra-articular morphine in a model of lipopolysaccharide-induced synovitis in horses." C Lindegaard, AB Frost, MH Thomsen, C Larsen, S Honoré-Hansen, PH Andersen. Oral presentation at the 10^th World Congress of Veterinary Anaesthesia. 31^st August to 4^th September, 2009, Glasgow, UK.

"Comparison of a composite measure pain-scale and a visual analogue scale for orthopaedic pain in horses." C Lindegaard, MH Thomsen, S Larsen, PH Andersen. Oral presentation at the 10^th World Congress of Veterinary Anaesthesia. 31^st August to 4^th September, 2009, Glasgow, UK.

"Analgesic efficacy of intra-articular morphine in horses with lipopolysaccharide-induced synovitis." C Lindegaard, MH Thomsen, S Larsen, PH Andersen. Oral presentation at the 10^th World Congress of Veterinary Anaesthesia. 31^st August to 4^th September, 2009, Glasgow, UK.

"An update and how to on equine pain management", Invited oral presentation at the Annual meeting of the Danish Equine Veterinarian Ass., Middelfart, Denmark, November 2, 2008.

"Pain management in equine colic - with special emphasis on the post operative period", presentation at the Annual Meeting of the  Nordic Equine Medicine Organization, Helsinki, Finland, March 28-30, 2008

"Ocular and Periorbital trauma and surgery", Lecture for Danish Equine Veterinarians, under education for Specialist approval. March 2008

"Pain and pain-modulation in horses", Lecture for Danish Equine Veterinarians, under education for Specialist approval. April 2007

"Analgesic and anti-inflammatory potentialof intra-articular morphine in an equine induced arthritis model." Presented to the faculty at Dept of Anesthesiology, Freie Universität Berlin, Berlin, Germany, March 9^th, 2006.

 "Analgesic and anti-inflammatory properties of locally administered opioids - with special emphasis on intra-articularly administered morphine"; oral presentation at the 2005 Abildgaard Symposium, Copenhagen, Denmark.

BIBLIOGRAPHY:

Fjeldborg, J, Lindegaard C, Ullum H. The Influence of Sedation on the Endoscopic Interpretation in the Pharynx and Larynx. Proc. of 8^th Congress of the World Equine Veterinary Association 2003, p. 89

Jacobsen S, Niewold TA, Halling-Thomsen M, Nanni S, Olsen E, Lindegaard C, et al. Serum amyloid A isoforms in serum and synovial fluid in horses with lipopolysaccharide-induced arthritis. Veterinary Immunology and Immunopathology 2006;110 (3-4):325-30.

Lindegaard C., Husted L., Ullum H. and Fjeldborg J. Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses. Equine Veterinary Journal, 2007, 39 (6): 553-556.

A.B. Frost, S. Jacobsen, M. Halling-Thomsen, C. Lindegaard; S.W. Larsen, J. Østergaard, P.H. Andersen, C. Larsen .Intra-articular drug disappearance kinetics - Reducing the number of in vivo experiments from establishment of in vitro in vivo correlation?. Poster at SHARE (Synergy in Human Animal Research) symposium, Nov 2007, University of Copenhagen, Copenhagen, Denmark

A.B. Frost, S. Jacobsen, MH Thomsen, C. Lindegaard; S.W. Larsen, J. Østergaard, P.H. Andersen, C. Larsen .Intra-articular drug disappearance kinetics - Reducing the number of in vivo experiments from establishment of in vitro-  in vivo correlation?. Poster. Annual meeting of the American Association of Pharmaceutical Scientists, November 16-20, 2008, Atlanta, GA, USA

Larsen C,C Østergaard J, Larsen S, Jensen H, Jacobsen S, Lindegaard C, Andersen Pia H. Intra-articular Depot Formulation Principles - Role in the Management of Postoperative Pain and Arthritic Disorders. J Pharm Sci, 2008, 47 (11): 4622-4654

Lindegaard C, Intra-articular morphine in horses - clinical properties in lipopolysaccharide-induced synovitis, PhD thesis, 2009, Faculty of Life Sciences, University of Copenhagen. Printed by SL grafik, Frederiksberg, Denmark; ISBN: 978-87-7611-303-2

Lindegaard C, Vaabengaard D, Christophersen M, Ekstøm C, Fjeldborg J, Evaluation of Pain and inflammation associated with hot iron branding and microchip transponder injection in horses. Am J Vet Res, 2009;70:840-847

Lindegaard C, Pihl TH, Andersen PH, Referred pain as a possible cause of poor performance in riding horses. Poster presented at the Annual conference of ECVS, Nantes, France, July 2009

S.W. Larsen, A.B. Frost, J. Østergaard1, S. Jacobsen, M.H. Thomsen, C. Lindegaard, P.H. Andersen and C. Larsen. In situ formed suspensions for local sustained action of celecoxib following intra-articular administration. Poster presented at the 36^th Annual meeting and Exhibition of the Controlled Release Society, Copenhagen, Denmark, July 2009

Accepted for publication

Lindegaard C, Bech-Gleerup K, Thomsen MH, Martinussen T, Andersen PH.  Anti-inflammatory effects of intra-articular morphine in experimentally induced joint inflammation in horses. Am J Vet Res, 2009.

Lindegaard, C, Thomsen, M, Larsen, S, Andersen, PH et al. Analgesic effect of intra-articularly administered morphine in a model of equine induced aseptic arthritis. Accepted for publication in Veterinary Anaesthesia and Analgesia received on 200609

Lindegaard C, Frost AB, Thomsen MH, Hansen SH, Andersen PH. Pharmacokinetics of intra-articular morphine in horses with lipopolysaccharide-induced synovitis. Accepted for publication in Veterinary Anaesthesia and Analgessia received on 221009.

Publications in work/to be submitted

Anna Buus Frost, Frank Larsen, Jesper Østergaard, Susan Weng Larsen, Casper Lindegaard, Helle Rüsz Hansen, Bente Gammelgaard, Claus Larsen. On the search for in vitro in vivo relations upon intra-articular administration of sodium diatrizoate to the horse. In review, Journal of Controlled Release

Maj Halling Thomsen1, Anders Tolver Jensen, Helle Sørensen, Casper Lindegaard, Pia

Haubro Andersen. Symmetry indices based on accelerometric data in trotting horses. In review, Journal of Biomechanics

Short presentation

Jeg er uddannet dyrlæge i januar 2002 og efter 1 ½ år i blandet praksis vendte jeg tilbage til det nuværende SUND (tidl. KVL) som klinikveterinær. I marts 2005 påbegyndte jeg en PhD-uddannelse indenfor området "Anæstesi og smertebehandling af store husdyr". Denne blev afsluttet med afhandlingen; "Intra-articular morphine in horses - clinical properties in lipopolysaccharide-induced synovitis", som blev forsvaret og godkendt d. 12. juni 2009.

Jeg har mellem 2008 og 2011 gennemgået den europeiske specialist uddannelse i stordyrskirurgi og fik i februar 2012 titlen "Diplomate of the European College of Veterinary Surgeons" (Dipl. ECVS). 

Fra marts 2012 til januar 2018 har jeg arbejdet som chefdyrlæge i kirurgi ved skandinaviens største hestehospital: Evidensia Specialisthästsjukhus Helsingborg, Sverige. Min arbejde i Helesingborg har givet mig en enorm kirurgisk erfaring indenfor artroksopi, øvre luftveje, sår, tænder, kolik og stort set alle andre kirurgiske problemer hos heste. 

I de sidste 2 år af min ansættelse hos Evidensia var jeg også involveret i ledelsen af Evidensia Sverige (Veterinärmedicinsk Ansvarlig Häst, 2016) og i hele Evidensia Norden samt en del af Independent Vet Care (Group Medical Director, 2017). Dette job bestod af ledelse og vejledning indenfor alle veterinærmedicinkse problemstillinger inklusive oprettelse af kvalitetssikring af virksomheden.

Under min tid på KU LIFE (Nu SUND) og i Evidensia har jeg forsket, publiceret og forelæst natinalt og internationalt indenfor øvre lufteveje, ortopedi og smerte. 

Jeg har stor interesse i al kirurgi, men specielt øvre luftvejskirurgi og ortopedisk kirurgi, inklusive alle typer af artroskopi (kikertoperationer). Jeg har også en dyb interesse for smertevurdering og smertebehandling af store husdyr. Jeg mener at optimal smertebehandling er meget vigtig for at sikre dyrevelfærd i forbíndelse med de, efterhånden, mere og mere avancerde indgreb vi kan udføre på vore husdyr. God smertebehandling, og dermed bedre velbefindende hos dyrene, er også med til at sikre hurtigere og bedre heling, og dermed kortere sygdomsforløb.

CV

June 2009

Defence of PhD thesis with the title: "Intra-articular morphine in horses - Clinical properties in lipopolysaccharide-induced synovitis"

August 2008 -

Residency (ECVS) in large animal surgery, University of Copenhagen, Faculty of Life Sciences, Department of Large Animal Sciences

February 2007 - February 2008

Scientific assistant and equine surgeon at University of Copenhagen, Faculty of Life Sciences, Department of Large Animal Sciences

March 2005- January 2007 and March 2008- July 2008

June 2003 -February 2004

Internship, Large Animal Hospital, Department of Large Animal Sciences, Royal Veterinary and Agricultural University, Copenhagen, Denmark

Assistant veterinary surgeon. Als Dyrlæger, Alsia Dyrehospital, Keglen 2, DK-6440 Augustenborg, Denmark.