Drug formulations based on self-assembled liquid crystalline nanostructures

TY - CHAP

T1 - Drug formulations based on self-assembled liquid crystalline nanostructures

AU - Yaghmur, Anan

AU - Østergaard, Jesper

AU - Larsen, Susan Weng

AU - Jensen, Henrik

AU - Larsen, Claus Selch

AU - Rappolt, Michael

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Among these self-assembled systems, the nonlamellar phases (mainly the H2 and V2 phases) are of particular interest because of the growing body of evidence for their essential role in the regulation of different biological processes such as membrane fusion, and fat digestion (Patton and Carey 1979, Luzzati, 1997, Almsherqi et al. 2006, Teres et al. 2008, Salentinig et al. 2011, Warren et al. 2011). In a recent review, Almsherqi et al. (2006) described the structures of membrane organization observed in different cells and gave particular interest in the formation of cubic biomembranes in various cells as a result of cell stresses, starvation, or lipid and protein alterations. Figure 17.1 shows examples of two different morphologies of membrane organizations in biological cells (Almsherqi et al. 2009). However, up to date the reports on the structure-function relationship of these biological nonlamellar assemblies are still scarce. Therefore, Hyde et al. (1997) emphasized that the role of curvature in biomembrane organization morphology is the “neglected” dimension in cellular and molecular biology.

AB - Among these self-assembled systems, the nonlamellar phases (mainly the H2 and V2 phases) are of particular interest because of the growing body of evidence for their essential role in the regulation of different biological processes such as membrane fusion, and fat digestion (Patton and Carey 1979, Luzzati, 1997, Almsherqi et al. 2006, Teres et al. 2008, Salentinig et al. 2011, Warren et al. 2011). In a recent review, Almsherqi et al. (2006) described the structures of membrane organization observed in different cells and gave particular interest in the formation of cubic biomembranes in various cells as a result of cell stresses, starvation, or lipid and protein alterations. Figure 17.1 shows examples of two different morphologies of membrane organizations in biological cells (Almsherqi et al. 2009). However, up to date the reports on the structure-function relationship of these biological nonlamellar assemblies are still scarce. Therefore, Hyde et al. (1997) emphasized that the role of curvature in biomembrane organization morphology is the “neglected” dimension in cellular and molecular biology.

M3 - Book chapter

SP - 341

EP - 360

BT - Liposomes, lipid bilayers and model membranes

A2 - Pabst, Georg

A2 - Kucerka, Norbert

A2 - Nieh, Mu-Ping

A2 - Katsaras, John

PB - CRC Press

CY - Boca Raton

ER -