PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

Claus Selch Larsen; Susan Weng Larsen; Mette Agergaard Thing; Jesper Langgaard Kristensen; HENRIK JENSEN,; JESPER OESTERGAARD,

PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

Claus Selch Larsen (Inventor), Susan Weng Larsen (Inventor), Mette Agergaard Thing (Inventor), Jesper Langgaard Kristensen (Inventor), HENRIK JENSEN, (Inventor), JESPER OESTERGAARD, (Inventor)

Abstract

The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.

Original language	English
IPC	C07D 487/ 04 A I
Patent number	WO2013064153
Country/Territory	Denmark
Priority date	31/10/2011
Priority number	DK20110070591
Publication status	Published - 10 May 2013

Cite this

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title = "PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)",

abstract = "The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.",

author = "Larsen, {Claus Selch} and Larsen, {Susan Weng} and Thing, {Mette Agergaard} and Kristensen, {Jesper Langgaard} and HENRIK JENSEN, and JESPER OESTERGAARD,",

year = "2013",

month = may,

day = "10",

language = "English",

type = "Patent",

note = "WO2013064153; C07D 487/ 04 A I",

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T1 - PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

AU - Larsen, Claus Selch

AU - Larsen, Susan Weng

AU - Thing, Mette Agergaard

AU - Kristensen, Jesper Langgaard

AU - JENSEN,, HENRIK

AU - OESTERGAARD,, JESPER

PY - 2013/5/10

Y1 - 2013/5/10

N2 - The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.

AB - The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.

M3 - Patent

M1 - WO2013064153

ER -

PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

Abstract

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