Camilla Foged

CV

• Full Professor of Vaccine Design and Delivery at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, 2018-present
• Group Leader at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, 2014-present
• Associate Professor at the Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, 2008-2018
• Post.Doc/Assistant Research Professor at the Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, 2004-2008 (maternity leave in 2005)
• Research Assistant at the Division of Hematology, Karolinska Hospital and Institute, Stockholm, Sweden, 2004
• Research Assistant at the Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, Copenhagen, Denmark, 2003
• Doctoral Fellow at the Department of Pharmaceutics, The Royal Danish School of Pharmacy, Copenhagen, Denmark, 1999-2003 (maternity leave in 2002)
• Research Fellow at Novo Nordisk A/S, Gentofte/Bagsværd, Denmark, 1996-1998
• ERASMUS Student at Dipartimento di Biotechnologie (DIBIT), Ospedale San Raffaele, and Universitá delgi Studi di Milano, Milano, Italy, 1996

Primary fields of research

I am leading the research group named Vaccine Design and Delivery at Department of Pharmacy (UCPH). Currently my group comprises 12 internationally recruited researchers and students. My research passion is advanced drug delivery, and we design new vaccine and nucleic acid delivery systems to improve therapy. My group is addressing drug delivery challenges using state of the art technologies, and this has fostered innovative solutions and high-impact publications in drug delivery. My research goal is to improve disease prevention and treatment in the fields of infectious and inflammatory diseases and cancer. We address these aims by imaging-guided design of nanoparticle-based vaccine and nucleic acid formulations through an in-depth and fundamental basic knowledge of how the physicochemical properties of the particles affect their interaction with the environment, i.e. in formulation, in vitro and in vivo. My group is one of the world-leading groups in the area of quality-by-design based engineering of innovative and high-quality nanomedicine formulations. We engage in research projects spanning from early discovery phase projects to first-in-man clinical studies. We address basic scientific questions in the field and are actively engaged in translational research. I am widely recognized nationally and internationally in the field of drug delivery, and I have a well-established and extensive network of collaborators in academia and industry. I have a track record of conducting and leading interdisciplinary research in collaboration with large international consortia. My research has been funded with more than EUR 7 million via prestigious and highly competitive grants from the Danish Research Councils, Universities, private companies, private foundations and EU.

I am heavily involved in the pre- and post-graduate science-based teaching at the School of Pharmaceutical Sciences. My teaching is in the areas of pharmaceutics, drug formulation and advanced drug delivery. At the BSc programme in Pharmacy, I primarily take part in the teaching in the Bachelor's Project in Pharmacy. I am involved in the teaching at the MSc programmes in Pharmacy, Pharmaceutical Sciences, Medicinal Chemistry and Immunology and Inflammation. This includes the courses Advanced Pharmaceutics and Immune Pharmacology. I also take part in the teaching at PhD courses offered by the Graduate School of Health and Medical Sciences, UCPH. For a number of years, I have been course leader for the PhD Course Drug Delivery. I am involved in recruitment of high school students via specific lectures for high school classes and supervision of individual high school students (forskerspire). I have supervised more than 124 graduate students, including 58 master students, 82 bachelor students, 12 scholar projects and 19 international students (guest students and ERASMUS students).

Current research

See our home page:

https://pharmacy.ku.dk/research/vaccine-design-delivery/

Graduated PhD students

Donglei Leng, Particle engineering of inhalable dry powder formulations for respiratory combination therapy

Letícia Rodrigues Neibecker, Development of Novel Vaccine Carriers: Physicochemical and Biological Characterization of Hexosomes

Birte Martin-Bertelsen, Structural Characterization of Lipid-based Adjuvants for Subunit Vaccines: Structure Activity Relationship for Analogues of the Mycobacterial Cell-Wall Lipid Monomycoloyl Glycerol

Signe Tandrup Schmidt, Targeted delivery of cytotoxic T-lymphocyte-inducing vaccines to cross-presenting dendritic cells. Design and characterization of lipid-based adjuvants

Gry Persson, Outer membrane vesicles and their potential as vaccine against Gallibacterium anatis

Rie Selchau Kallerup, Structure Activity Relationship (SAR) of Immunostimulating Compounds: Analogues of the Synthetic Immunostimulator Trehalose 6,6'-dibehenate (TDB)

Jorrit Jeroen Water, Nanoparticle-based approaches for delivery of antimicrobial peptides

Feng Wan, Design of Injectable PLGA Microparticles by the Spray Drying Process. Role of solvent properties and nozzle design

Stefano Colombo, Investigations of Nanocarrier-Mediated Cellular siRNA Delivery Processes Using Advanced Analytical Approaches

Pall Thor Ingvarsson, Formulating the DDA/TDB Liposomal Adjuvant into Nanocomposite Solid Microparticles for Pulmonary Vaccination: Dry Powder Stabilization and in vitro Interactions with Pulmonary Epithelial Cells

Mette Hamborg, Physical Stability of Subunit Vaccines:Interactions between Liposomal Adjuvants and Protein Antigens

Xiaona Jing, Peptide-assisted (Particulate) Drug Delivery Systems for Delivery of Biomacromolecules

Nina Østergaard Knudsen, Advanced targeting of liposomes to the skin

Linda Boye Jensen, Design and investigation of nanoparticles for targeted delivery of small interfering RNA (siRNA)

Pernille Nordly, Modulation of the adjuvant activity of DDA/TDB liposomes with immunostimulating ligands targeting dendritic cell receptors

Dennis Christensen, Optimization and characterization of adjuvant formulations based on cationic liposomes and immunomodulating compounds

Master Students

Dennis Sulbæk, 2020, ongoing

Siqi Feng, 2020, ongoing

Anas Samir Mohammad Aljabbari, 2020, ongoing

Abishek Wadhwa, 2020, ongoing

Guillermo Cano, 2019, Identification of factors of importance for the design and dosing of an inhalable solid dosage for of the tuberculosis subunit vaccine candidate H56/CAF01

Marthe Simonsen, 2019, Design of novel siRNA delivery systems based on lipid-polymer hybrid nanoparticles for RNAi therapy of chronic obstructive pulmonary disease

Pauliina Ranne, 2019, Comparison of Lipid-Polymer Hybrid Nanoparticles Formulated by Single and Double Emulsion Solvent Evaporation Method 

Abhijeet Lokras, 2019, A quality-by-design approach for loading an anti-inflammatory siRNA in lipidoid-polymer hybrid nanoparticles 

Katharina Wørzner, 2019, Determining the effect of attractive electrostatic interactions between lysozyme and liposomal adjuvants on the immune response in vivo

Caroline Plesner Jacobsen, 2019, The Chain Length of Novel Lipidoids, Intended for Efficient and Safe Intracellular Delivery of siRNA, is Decisive for in vitro Transfection Potential and Immunogenicity

Johanna Hvannastein, 2018, Modification of Antigen Isoelectric Point: Influence on Antibody and T Cell Responses Induced by Cationic Liposomes

Diana C. Ljungkvist and Catharina Razer, 2018,Pharmacodynamics and Pharmacokinetics in Galleria mellonella Larvae: Evaluation of Liquid Chromatography – Mass Spectrometry for Quantification of Meropenem in Larval Hemolymph and Tissue-Lysed Samples

Sarah Larsen, 2018, The Role of Sestrin1 and Sestrin2 in Cell Death Mediated by Cisplatin, a Flow Cytometric Study

Henrik Vester, 2018, Development of hydrogel formulations for drug delivery using biorthogonal click chemistry

Ann-Kathrin Stein, 2018, A novel hapten as a vaccine against methamphetamine use disorder - An in vivo behaviourak study and synthesis and design optimisation

Simon Papai, 2018, Lipid–polymer hybrid nanoparticles (LPNs) for efficient intracellular delivery of antisense oligonucleotides

Agnieszka Samsel, 2018, Optimization of TNF-α siRNA-loaded lipidoid-PLGA hybrid nanoparticles: A novel technique for quantification of siRNA encapsulation efficiency

Shaquib Rahman Ansari, 2018, Design and Optimization of Gadoteridol-Loaded DDA/TDB Liposomes: A Quality-by-Design Approach

Karolina Sanicka, 2018, Identification of factors of importance for the design of an inhalable solid dosage form of the tuberculosis subunit vaccines H56/CAF04 and H56/CAF09

Cypriane Dormenval, 2018, Identification of factors of importances for the design of an inhalable solid dosage form of small interfering RNA-loaded lipidoid-poly(DL-lactic-co.glycolic acid) hybrid nanoparticles

Malene Aaby Neustrup, 2017, Formulation and Characterisation of Nanoemulsion-Based Adjuvants Mediating Vaccine-Induced CD8+ T-Cell Responses

Sabrine Fuglsbjerg Ramdal Lægteskov, 2017, Delivery of a combination of siRNA and peptide for the treatment of rheumatoid arrhritis - Formulaion optimization 

Sarah Tejlmann, 2016, Formulation and characterization of stabilized nucleic acid lipid particles for delivery of siRNA: Comparison with lipoplexes and lipid-polymer hybrid nanoparticles

Pernille Rønde Jensen, 2016, Degradation profiles of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-based Antigen CTH522: Comparison of three GMP-produced batches

Camilla Line Olsen, 2016, Formulation, Charaterization and In Vivo Test of CAF Adjuvants             

Michaela Czort, 2016, Solid Lipid Particles for Oral Delivery of Vaccines. Particle preparation, characterization and quantification and protein characterization

Elisabeth Bergholt, 2016, CL-HA hydrogels incorporated with PLGA nanoparticles for controlled release in the treatment of rheumatoid arthritis

Carla Roches, 2014, Biophysical characterization of liposomal adjuvants based on dimethyldioctadecylammonium (DDA) bromide and monomycoloyl glycerol (MMG): Differential scanning calorimetry (DCS), small angle X-ray scattering (SAXS) and cryo transmission electron microscopy (cryo-TEM) studies.

Jia Shi, 2014, Effect of the trehalose-6, 6’dibehenate (TDB) analogue modification on the physicochemical properties of a cationic adjuvant system

Przemyslaw Jedrzej Irlik, 2013, Mucosal vaccination: Interactions between mucosal epithelium and mucosal vaccines. Mechanistic studies

Camilla Hasling Frandsen, 2013, Vancomycin-Loaded Multi-and Unilamellar Cationic Liposomes: Treatment of Staphylococcus Aureus

Kasper Karlsen, 2013, Identification and characterization of novel cationic adjuvant formulations: Toll-like receptor ligands incorporated into liposomes for use against intracellular infections

Elizaveta Kamynina, 2013, Oromucosal drug delivery using liposomes for alleviation of xerostomia

Angelos Moschidis and Xing Hanyue, 2013, Methotrexate-loaded deformable liposomes for dermal delivery

Cecilie Maria Madsen, 2012, The effect of the acyl chain length of trehalose-6,6’-dibehenate on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

Katrine Vidensen Bjørklund, 2012, Interactions between liposomal adjuvants and protein antigens: Effect of liposome surface charge, protein physicochemical properties and heating

Signe Tandrup Schmidt, 2012, Formulation of CAF09 to enhance the CD8+ T-cell response after subcutaneous immunization

Helene Brøndum Pedersen, 2012, Liposome-based cationic adjuvants: Interactions with antigens. The effect of charge

Mona Mekki, 2012, siRNA delivery by non-viral carriers

Matias Rosenkvist, 2011, Spray Dried Powders for Pulmonary Delivery: A Comparative Study of Methods for Particle Size

Mehtap Tellioglu, 2011, Encapsulation of Ovalbumin into DDA/TDB Liposomes Prepared by the Double Emulsion Solvent Evaporation Method. Characterization of Interactions at the Interface

Ida Svahn Rasmussen, 2011, Effect of liposomal charge on mucosal vaccine delivery: An in vitro study

Cathrine Roer, 2010, Controlled Surface Modifications of PLGA Nanoparticles Using Cell Penetrating Peptides for Efficient Delivery of siRNA

Veronika Gadzhyeva, 2010, Karakterisering af PAMAM-siRNA komplekser af generationer G1, G4 og G7 ved forskellige molære ratioer

Tanja Pedersen & Rukiye Karaman, 2010, Karakterisering af DDA/TDB liposomer ved inkorporering af forskellige størrelser polynukleotider

Stine Rønholt & Ragnhild Djønne Salte, 2009, Skin penetration of PEGylated liposomes

Esra Alici Pedersen & Tayba Sajid Khilji, 2009, Characterization of incorporation of monomycolylglycerol in dimethyldioctadecylammoniumbromide liposomes

Anders Simonsen, 2009, Interaction between novel cell-penetrating peptides and anionic liposomes: Thermodynamic and structural assessment

Rasmus Bjerregaard-Andersen, 2009, Interaction of a new class of cell-penetrating peptides (CPP) with model lipid membranes

Ditte Marie Krogh Jensen, 2008, Spray-drying Preparation of Microparticles Containing siRNA-loaded PLGA Nanoparticles

Andreas Jensen, 2008, Neutral Conventional and Stealth Liposomes for i.v. Administration of siRNA

Ali Rehman, 2007, Spray drying of chitosan/siRNA nanoparticles with mannitol

Sibel Tokmak, 2007, HL10 Liposomes as Drug Delivery System for siRNA-Chol

Henriette Baun Madsen, 2006, Preparation and Characterization of the PROVAX^TM adjuvant

Elisabeth Giger, 2006, Long-circulating liposomes for secretory phospholipase A2 triggered release of siRNA in inflamed tissue – in vitro studies of TNF-α silencing in the murine macrophage cell culture J774A.1

Peter Merrild, 2004, Interaction between antimicrobial peptides and biological membranes

Bettina Bruun, 2001, Polymeric delivery of camptothecin analogs and rabbit carboxylesterase

Jeannet Kall, 2001, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of polyamine analogs

ERASMUS Students

Elisa De Meester, 2019, PLGA Nanoparticles as Delivery System for Antimicrobial Peptides

Jenny Lai, 2018, Nanoparticle-Mediated Co-Delivery of Small Interfering RNA and Heat Shock Protein 70-Peptide B29 for the Treatment of Rheumatoid Arthritis

Delphine Van Eetvelde, 2018, In vitro release assesment of siRNA from lipid-polymer hybrid nanoparticles

Elisabeth Bombarda, 2017, Design of a thermostable TB vaccine for pulmonary delivery: Comparison between the biophysical stability of fusion protein antigen H56 and OVA model antigen

Hannelore Van Eygen, 2017, Investigations into the in vitro release kinetics of siRNA from Lipid–polymer hybrid nanoparticles (LPNs)

Francesca Gavins, 2017, Design of a mucosal adjuvant based on glycol chitosan-coated lipid-polymer hybrid nanoparticles for vaccination against chlamydia

Emma Putteman, 2016, Assesment of stability and release kinetics of siRNA loaded into lipid-polymer hydrid nanoparticles

Danielle Dennehy, 2015, PLGA nanoparticles for siRNA delivery in vitro

Elize Van Driessche, 2015, Preparation and optimization of lipid-PLGA nanoparticles for siRNA delivery

Monica Agnoletti, 2015, Design of siRNA-loaded dendriplexes in microparticles prepared by microfluidics and spray drying

Tamanna Lashkari, 2014, Dry powder stabilization of freeze-dried CAF01 liposomes by trehalose and/or inulin

Silke Roovers, 2014, Biophysical characterization and understanding of the aggregation mechanism of model antigen ovalbumin and vaccine candidate NN-GBS

Olivier de Troyer, 2013, Biophysical characterization of the mycobacterial cell wall lipid monomycoloyl glycerol

Erik Oude Blenke, 2012, Cell Penetrating Peptidomimetic-Functionalized Lipid Systems for siRNA Delivery

Michelle Viaene, 2012, Effect of liposomal charge on pulmonary vaccine delivery

Ivo Verlinden, 2011, Formulation and in vivo effectiveness of the CAF05 adjuvant in a ferret influenza challenge model

Joscha Griger, 2009, Toxicogenomic effects of polymeric siRNA delivery in vitro

Hayley Rose March, 2007, Assessment of the Structure of the M. Tuberculosis antigen Ag85b-ESAT-6 and the changes in secondary structure on interaction with DDA/TDB Liposomes 

Scholar students

Veronica Martini, 2016-2017

Emily Falkenberg, 2016-2017

Sofie Lillelund Ovesen, 2016-2017

Sarah Justesen, 2013-2014

Mikkel Lohmann Schiøth, 2012

Lasse Bengtson, 2010-2011

Anders Riber Bojsen, 2009-2010

Signe Tandrup Schmidt, 2009-2010

Maja Hauge Nielsen, 2008-2009

Martin Blaedel, 2007

Tejs Pedersen, 2007

Rie Selchau Kallerup, 2004-2005