Rune Ehrenreich Kuhre

2019

Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine

Booz, V., Christiansen, C. B., Kuhre, R. E., Saltiel, M. Y., Sociali, G., Schaltenberg, N., Fischer, A. W., Heeren, J., Zocchi, E., Holst, J. J. & Bruzzone, S., 1 Feb 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 8 p., e3102.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

Vestergaard, E. T., Hjelholt, A. J., Kuhre, R. E., Møller, N., Larraufie, P., Gribble, F. M., Reimann, F., Jessen, N., Holst, J. J. & Jørgensen, J. O. L., 21 Mar 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2581-2592

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Christiansen, C. B., Trammell, S. A. J., Albrechtsen, N. J. W., Schoonjans, K., Albrechtsen, R., Gillum, M. P., Kuhre, R. E. & Holst, J. J., May 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

1 Downloads (Pure)

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Kuhre, R. E. & Holst, J. J., 26 Feb 2019, In: Journal of Visualized Experiments. 144, e58533.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

1 Downloads (Pure)

Neuromedin U Does Not Act as a Decretin in Rats

Kuhre, R. E., Christiansen, C. B., Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, I. M., Mandrup-Poulsen, T., Albrechtsen, R., Rosenkilde, M. M., Hartmann, B., Albrechtsen, N. J. W. & Holst, J. J., 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

15 Downloads (Pure)

No direct effect of SGLT2 activity on glucagon secretion

Kuhre, R. E., Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, N. J. W., Andersen, D. B., Aivazidis, A., Chen, L., Mandrup-Poulsen, T., Ørskov, C., Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, J. J., 1 Jun 2019, In: Diabetologia. 62, 6, p. 1011-1023

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors

Modvig, I. M., Kuhre, R. E. & Holst, J. J., Apr 2019, In: Physiological Reports. 7, 8, 13 p., e14056.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

29 Downloads (Pure)

2018

Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

Christiansen, C. B., Lind, S. J., Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, R. E., Hartmann, B., Mandrup-Poulsen, T., Deacon, C. F., Albrechtsen, N. J. W. & Holst, J. J., Jul 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

46 Downloads (Pure)

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., Deacon, C. F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, R., Hartmann, B., Rosenkilde, M. & Holst, J. J., 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

60 Citations (Scopus)

60 Downloads (Pure)

2017

Abscisic acid controls the release of insulin from beta-cells, Glucagon-Like Peptide-1 from intestinal L-cells and glucagon from alpha-cells

Booz, V., Christiansen, C. B., Kuhre, R. E., Saltiel, M. Y., Sturla, L., Sociali, G., Zocchi, E., Holst, J. J. & Bruzzone, S., 2017, In: European Journal of Clinical Investigation. 47, p. 112-113

Research output: Contribution to journal › Conference abstract in journal › Research

A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

Wewer Albrechtsen, N. J., Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, R. E., Asmar, M., Veedfald, S., Plamboeck, A., Knop, F. K., Vilsbøll, T., Madsbad, S., Nauck, M. A., Deacon, C. F., Bülow, J., Holst, J. J. & Hartmann, B., 1 Sept 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass

Nielsen, S., Svane, M. S., Kuhre, R. E., Clausen, T. R., Kristiansen, V. B., Rehfeld, J. F., Holst, J. J., Madsbad, S. & Bojsen-Moller, K. N., 1 Feb 2017, In: Physiological Reports. 5, 3, 11 p., e13140.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

53 Downloads (Pure)

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N., & 9 othersIdorn, T., Deacon, C. F., Knop, F. K., Rosenkilde, M. M., Hartmann, B., Feldt-Rasmussen, B., Mann, M., Madsbad, S. & Holst, J. J., 7 Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

119 Downloads (Pure)

On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat

Kuhre, R. E., Christiansen, C. B., Saltiel, M. Y., Albrechtsen, N. J. W. & Holst, J. J., 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

73 Downloads (Pure)

Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

Saltiel, M. Y., Kuhre, R. E., Christiansen, C. B., Eliasen, R., Conde-Frieboes, K. W., Rosenkilde, M. M. & Holst, J. J., 22 Apr 2017, In: Nutrients. 9, 4, 15 p., 418.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

68 Downloads (Pure)

Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

Windeløv, J. A., Wewer Albrechtsen, N. J., Kuhre, R. E., Jepsen, S. L., Hornburg, D., Pedersen, J., Jensen, E. P., Galsgaard, K. D., Winther-Sørensen, M., Ørgaard, A., Deacon, C. F., Mann, M., Kissow, H., Hartmann, B. & Holst, J. J., 1 Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2016

Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

Albrechtsen, N. J. W., Kuhre, R. E., Windeløv, J. A., Ørgaard, A., Deacon, C. F., Kissow, H., Hartmann, B. & Holst, J. J., 1 Aug 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

Albrechtsen, N. J. W., Albrechtsen, R., Bremholm, L., Svendsen, B., Kuhre, R. E., Poulsen, S. S., Christiansen, C. B., Jensen, E. P., Janus, C., Hilsted, L., Deacon, C. F., Hartmann, B. & Holst, J. J., 13 Dec 2016, In: Cell Reports. 17, 11, p. 2845-2856 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

553 Downloads (Pure)

Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

Wewer Albrechtsen, N. J., Hornburg, D., Albrechtsen, R., Svendsen, B., Toräng, S., Jepsen, S. L., Kuhre, R. E., Hansen, M., Janus, C., Floyd, A., Lund, A., Lauritsen, T. V., Knop, F. K., Vestergaard, H., Deacon, C. F., Meissner, F., Mann, M., Holst, J. J. & Hartmann, B., 1 May 2016, In: EBioMedicine. 7, p. 112-120 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

Kuhre, R. E., Albrechtsen, N. J. W., Deacon, C. F., Balk-Møller, E., Rehfeld, J. F., Relman, F., Gribble, F. M. & Holst, J. J., Apr 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

The biology of glucagon and the consequences of hyperglucagonemia

Wewer Albrechtsen, N. J., Kuhre, R. E., Pedersen, J., Knop, F. K. & Holst, J. J., Nov 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

175 Downloads (Pure)

The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs

Albrechtsen, N. J. W., Kuhre, R. E., Toräng, S. & Holst, J. J., 2 Feb 2016, In: BMC Research Notes. 9, 1, p. 1-6 6 p., 60.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

52 Downloads (Pure)

The regulation of function, growth and survival of GLP-1-producing L-cells.

Kuhre, R. E., Holst, J. J. & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.

Research output: Contribution to journal › Review › peer-review

22 Citations (Scopus)

2015

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

Brighton, C. A., Rievaj, J., Kuhre, R. E., Glass, L. L., Schoonjans, K., Holst, J. J., Gribble, F. M. & Reimann, F., Nov 2015, In: Endocrinology. 156, 11, p. 3961-1370 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

157 Citations (Scopus)

Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx

Kuhre, R. E., Bechmann, L. E., Hartmann, B., Albrechtsen, N. J. W. & Holst, J. J., 15 Jun 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 12, p. E1123–E1130 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

Kuhre, R. E., Wewer Albrechtsen, N. J., Hartmann, B., Deacon, C. F. & Holst, J. J., 1 Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

Kuhre, R. E., Frost, C. R., Svendsen, B. & Holst, J. J., 1 Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

93 Citations (Scopus)

Stability of glucagon-like peptide-1 and glucagon in human plasma

Albrechtsen, N. J. W., Bak, M. J., Hartmann, B., Christensen, L. W., Kuhre, R. E., Deacon, C. & Holst, J. J., 16 Jan 2015, In: Endocrine Connections. 4, 1, p. 50-57 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine

Christensen, L. W., Kuhre, R. E., Janus, C., Svendsen, B. & Holst, J. J., 17 Sept 2015, In: Physiological Reports. 3, 9, p. 1-13 13 p., e122551.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

2014

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans

Kuhre, R. E., Gribble, F. M., Hartmann, B., Reimann, F., Windeløv, J. A., Rehfeld, J. F. & Holst, J. J., 1 Apr 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 306, 7, p. G622-30 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines

Kuhre, R. E., Albrechtsen, N. J. W., Windeløv, J. A., Svendsen, B., Hartmann, B. & Holst, J. J., May 2014, In: Peptides. 55, p. 52-57 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Glucose Stimulates GLP-1 Secretion from Isolated Perfused Rat Small Intestine by SGLT1 and GLUT2 Mediated Uptake, Causing V-gated Calcium Channel Activation

Kuhre, R. E., Frost, C. R., Svendsen, B. & Holst, J. J., Jun 2014, In: Diabetes. 63, suppl 1, p. A491 1 p., Abstract no 1915-P.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Incretin secretion: direct mechanisms

Balk-Møller, E., Holst, J. J. & Kuhre, R. E., 12 Jun 2014, Diapedia: The living textbook of diabetes. European Association for the Study of Diabetes (EASD), p. 1-3 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication

Pancreatic effects of GLP-1

Kuhre, R. E., Albrechtsen, N. J. W. & Holst, J. J., 22 Dec 2014, Diapedia: The Living Textbook of Diabetes. European Association for the Study of Diabetes (EASD)

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication

73 Citations (Scopus)

Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

Albrechtsen, N. J. W., Kuhre, R. E., Deacon, C. F. & Holst, J. J., 1 Jan 2014, In: Expert Review of Endocrinology & Metabolism. 9, 1, p. 61-72 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2011

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, R., Egerod, K. L., Nielsen, L. B., Schwartz, T. W. & Holst, B., Nov 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Rune Ehrenreich Kuhre

Research output

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