Abstract
Degradation-resistant glucagon-like peptide-1 (GLP-1) mimetics and GLP-1 enhancers (inhibitors of dipeptidyl peptidase-4, the enzyme which degrades and inactivates GLP-1) have been used for treatment of type 2 diabetes mellitus since 2005-2006. Cutting-edge research is now focusing on uncovering the secretory mechanisms of the GLP-1-producing cells (L-cells) with the purpose of developing agonists that enhance endogenous hormone secretion. Since GLP-1 co-localizes with other anorectic peptides, cholecystokinin, oxyntomodulin/glicentin and peptide YY, L-cell targeting might cause release of several hormones at the same time, providing additive effects on appetite and glucose regulation. In this review, we explore the role of proglucagon-derived peptides and other L-cell co-localizing hormones, in appetite regulation and the mechanism regulating their secretion.
| Original language | English |
|---|---|
| Journal | Expert Review of Endocrinology & Metabolism |
| Volume | 9 |
| Issue number | 1 |
| Pages (from-to) | 61-72 |
| Number of pages | 12 |
| ISSN | 1744-6651 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
Keywords
- appetite regulation
- gut hormones
- gut-brain axis
- L-cell
- obesity
