Peter Johannes Holst

2019

CD8+T cells induced by adenovirus-vectored vaccine are capable of preventing establishment of latent murine gamma-herpesvirus 68 infection

Boilesen, D. R., Ragonnaud, E., Laursen, H., Andersson, A-M. C., Tolver, A., Spiess, K. & Holst, P. J., 16 May 2019, In: Vaccine. 37, 22, p. 2952-2959 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination

Fougeroux, C., Turner, L., Bojesen, A. M., Laystsen, T. & Holst, P. J., 15 Apr 2019, In: Journal of Immunology. 202, 8, p. 2320-2331

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Schwerdtfeger, M., Andersson, A. M. C., Neukirch, L. & Holst, P. J., 2019, In: Journal of Translational Medicine. 17, 1, 18 p., 175.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

23 Downloads (Pure)

2018

EBI2 in splenic and local immune responses and in autoimmunity

Barington, L., Wanke, F., Niss Arfelt, K., Holst, P. J., Kurschus, F. C. & Rosenkilde, M. M., 2018, In: Journal of Leukocyte Biology. 104, 2, p. 313-322 10 p.

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae

Antenucci, F., Fougeroux, C., Deeney, A., Ørskov, C., Rycroft, A., Holst, P. J. & Bojesen, A. M., Jan 2018, In: Veterinary Research. 49, 1, 11 p., 4.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

163 Downloads (Pure)

Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques

Ragonnaud, E., Schroedel, S., Mariya, S., Iskandriati, D., Pamungkas, J., Fougeroux, C., Daradoumis, J., Thomsen, A. R., Neukirch, L., Ruzsics, Z., Salomon, M., Thirion, C. & Holst, P. J., 2018, In: Vaccine. 36, 41, p. 6212-6222 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Virus-like-vaccines against HIV

Andersson, A. M. C., Schwerdtfeger, M. & Holst, P. J., Mar 2018, In: Vaccines. 6, 1, 17 p., 10.

Research output: Contribution to journal › Review › peer-review

11 Citations (Scopus)

175 Downloads (Pure)

2017

Breadth of T cell responses after immunization with adenovirus vectors encoding ancestral antigens or polyvalent papillomavirus Antigens

Ragonnaud, E., Pedersen, A. G. & Holst, P. J., 1 Mar 2017, In: Scandinavian Journal of Immunology. 85, 3, p. 182-190 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies

Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Pravsgaard Christensen, J., Randrup Thomsen, A., Egerod, K. L., Bassi, M. R., Spiess, K., Schwartz, T. W., Wang, H., Morse, H. C., Holst, P. J. & Rosenkilde, M. M., 16 Feb 2017, In: Blood. 129, 7, p. 866-878

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Future prospects for the development of cost-effective Adenovirus vaccines

Fougeroux, C. & Holst, P. J., 23 Mar 2017, In: International Journal of Molecular Sciences. 18, 4, 12 p., 686.

Research output: Contribution to journal › Review › peer-review

20 Citations (Scopus)

71 Downloads (Pure)

Identification and characterization of serovar-independent immunogens in Actinobacillus pleuropneumoniae

Antenucci, F., Fougeroux, C., Bosse, J. T., Magnowska, Z., Roesch, C., Langford, P., Holst, P. J. & Bojesen, A. M., 9 Nov 2017, In: Veterinary Research. 48, 12 p., 74.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

76 Downloads (Pure)

Mucosal vaccination with heterologous viral vectored vaccine targeting subdominant SIV accessory antigens strongly inhibits early viral replication

Xu, H., Andersson, A-M. C., Ragonnaud, E., Boilesen, D., Tolver, A., Jensen, B. A. H., Blanchard, J. L., Nicosia, A., Folgori, A., Colloca, S., Cortese, R., Thomsen, A. R., Christensen, J. P., Veazey, R. S. & Holst, P. J., Apr 2017, In: EBioMedicine. 18, p. 204–215 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

86 Downloads (Pure)

Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen

Andersson, A-M. C., dos Santos Marques Resende, M., Salanti, A., Nielsen, M. A. & Holst, P. J., 22 Feb 2017, In: Vaccine. 35, 8, p. 1140-1147 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Therapeutic vaccine against primate papillomavirus infections of the cervix

Ragonnaud, E., Andersson, A-M. C., Mariya, S., Pedersen, A. G., Burk, R. D., Folgori, A., Colloca, S., Cortese, R., Nicosia, A., Pamungkas, J., Iskandriati, D. & Holst, P. J., 7 Feb 2017, In: Journal of Immunotherapy. 40, 2, p. 51-61 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2016

An adenoviral cancer vaccine co-encoding a tumor associated antigen together with secreted 4-1BBL leads to delayed tumor progression

Ragonnaud, E., Andersson, A-M. C., Pedersen, A. E., Laursen, H. & Holst, P. J., 19 Apr 2016, In: Vaccine. 34, 18, p. 2147-2156 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Combined local and systemic immunization is essential for durable T-cell mediated heterosubtypic immunity against influenza A virus

Uddbäck, I. E. M., Pedersen, L. M. I., Pedersen, S. R., Steffensen, M. A., Holst, P. J., Thomsen, A. R. & Christensen, J. P., 1 Feb 2016, In: Scientific Reports. 6, 15 p., 20137.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

77 Downloads (Pure)

Early life vaccination: Generation of adult-quality memory CD8⁺ T cells in infant mice using non-replicating adenoviral vectors

Nazerai, L., Bassi, M. R., Uddbäck, I. E. M., Holst, P. J., Christensen, J. P. & Thomsen, A. R., 8 Dec 2016, In: Scientific Reports. 6, 17 p., 38666.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

112 Downloads (Pure)

Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations

Andersson, A. M. C., Ragonnaud, E., Seaton, K. E., Sawant, S., Folgori, A., Colloca, S., Labranche, C., Montefiori, D. C., Tomaras, G. D. & Holst, P. J., 17 Oct 2016, In: Vaccine. 34, 44, p. 5344-5351 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Increased T cell breadth and antibody response elicited in prime-boost regimen by viral vector encoded homologous SIV Gag/Env in outbred CD1 mice

Andersson, A. M. C. & Holst, P. J., 20 Dec 2016, In: Journal of Translational Medicine. 14, 10 p., 343.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

78 Downloads (Pure)

Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

Clausen, T. M., Bento Ayres Pereira, M. M., Al Nakouzi, N., Oo, H. Z., Agerbæk, M. Ø., Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, P. J., Theander, T., Sorensen, P. H., Daugaard, M. & Salanti, A., 1 Dec 2016, In: Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

2015

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R., & 15 othersThrane, S., Holst, P. J., Meng, L., Favero, F., Weiss, G. J., Nielsen, M. A., Freeth, J., Nielsen, T. O., Zaia, J., Tran, N. L., Trent, J., Babcook, J. S., Theander, T. G., Sorensen, P. H. & Daugaard, M., 12 Oct 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

93 Citations (Scopus)

Targeting of non-dominant antigens as a vaccine strategy to broaden T-cell responses during chronic viral infection

Holst, P. J., Jensen, B. A. H., Ragonnaud, E., Thomsen, A. R. & Christensen, J. P., 13 Feb 2015, In: PLOS ONE. 10, 2, 17 p., e0117242.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

148 Downloads (Pure)

2014

Co-expression of tumor antigen and interleukin-2 from an adenoviral vector augments the efficiency of therapeutic tumor vaccination

Jensen, B. A. H., Steffensen, M. A., Nørgaard Nielsen, K., Christensen, J. P., Thomsen, A. R. & Holst, P. J., 11 Dec 2014, In: Molecular Therapy. 22, 12

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice

Bartholdy, C., Høgh-Petersen, M., Storm, P., Holst, P. J., Orskov, C., Christensen, J. P. & Thomsen, A. R., Jun 2014, In: Scandinavian Journal of Immunology. 79, 6, p. 395-403 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2013

Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells

Pedersen, J., Ugleholdt, R. K., Jørgensen, S. M., Windeløv, J. A., Grunddal, K. V., Schwartz, T. W., Füchtbauer, E-M., Poulsen, S. S., Holst, P. J. & Holst, J. J., 1 Jan 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 304, 1, p. E60-73 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Qualitative and quantitative analysis of Ad5 vector induced memory CD8 T cells: not as bad as their reputation

Steffensen, M. A., Holst, P. J., Steengaard, S. S., Jensen, B. A. H., Bartholdy, C., Stryhn, A., Christensen, J. P. & Thomsen, A. R., Jun 2013, In: Journal of Virology. 87, 11, p. 6283-6295 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Qualitative and quantitative analysis of adenovirus type 5 vector-induced memory CD8 T cells: not as bad as their reputation

Steffensen, M. A., Holst, P. J., Steengaard, S. S., Jensen, B. A. H., Bartholdy, C., Buus, A. S., Christensen, J. P. & Thomsen, A. R., Jun 2013, In: Journal of Virology. 87, 11, p. 6283-6295 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

2012

Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses

Steffensen, M. A., Jensen, B. A. H., Holst, P. J., Bassi, M. R., Christensen, J. P. & Thomsen, A. R., 13 Apr 2012, In: P L o S One. 7, 4, 14 p., e34884.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

2011

Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

Mikkelsen, M., Holst, P. J., Bukh, J., Thomsen, A. R. & Christensen, J. P., 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST

Benned-Jensen, T., Smethurst, C., Holst, P. J., Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, T. W., Blanchard, A., Jepras, R. & Rosenkilde, M. M., 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Matrix metalloproteinase-8 overexpression prevents proper tissue repair

Danielsen, P. L., Holst, A. V., Maltesen, H. R., Bassi, M. R., Holst, P. J., Heinemeier, K. M., Olsen, J., Danielsen, C. C., Poulsen, S. S., Jorgensen, L. N. & Agren, M. S., Nov 2011, In: Surgery. 150, 5, p. 897-906 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

Ugleholdt, R., Pedersen, J., Bassi, M. R., Füchtbauer, E-M., Jørgensen, S. M., Kissow, H., Nytofte, N., Poulsen, S. S., Rosenkilde, M. M., Seino, Y., Thams, P., Holst, P. J. & Holst, J. J., 30 Dec 2011, In: The Journal of Biological Chemistry. 286, 52, p. 44632-44645 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Vaccination against lymphocytic choriomeningitis virus infection in MHC class II-deficient mice

Holst, P. J., Christensen, J. P. & Thomsen, A. R., 1 Apr 2011, In: Journal of Immunology. 186, 7, p. 3997-4007

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2010

Adenoviral vaccination combined with CD40 stimulation and CTLA-4 blockage can lead to complete tumor regression in a murine melanoma model

Sørensen, M. R., Holst, P. J., Steffensen, M. A., Christensen, J. P. & Thomsen, A. R., 24 Sept 2010, In: Vaccine. 28, 41, p. 6757-64 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

DNA fusion gene vaccines

Holst, P. J., Bassi, M. R., Thomsen, A. R. & Christensen, J. P., Feb 2010, In: Current Opinion in Molecular Therapeutics. 12, 1, p. 47-54 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Quality of the transgene-specific CD8+ T cell response induced by adenoviral vector immunization is critically influenced by virus dose and route of vaccination

Holst, P. J., Ørskov, C., Thomsen, A. R. & Christensen, J. P., 15 Apr 2010, In: Journal of Immunology. 184, 8, p. 4431-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The murine gammaherpesvirus-68 chemokine-binding protein M3 inhibits experimental autoimmune encephalomyelitis

Millward, J. M., Holst, P. J., Høgh-Petersen, M., Thomsen, A. R., Christensen, J. P. & Owens, T., Jul 2010, In: Journal of Neuroimmunology. 224, 1-2, p. 45-50 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2009

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination

Elvang, T., Christensen, J. P., Billeskov, R., Thi Kim Thanh Hoang, T., Holst, P., Thomsen, A. R., Andersen, P. & Dietrich, J., 2009, In: PLoS ONE. 4, 4, p. e5139

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Fusion of a viral antigen to invariant chain leads to augmented T-cell immunity and improved protection in gene-gun DNA-vaccinated mice

Grujic, M., Holst, P. J., Christensen, J. P. & Thomsen, A. R., 2009, In: Journal of General Virology. 90, Pt 2, p. 414-22 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Mucosal immunization with recombinant adenoviral vectors expressing murine gammaherpesvirus-68 genes M2 and M3 can reduce latent viral load

Hoegh-Petersen, M., Thomsen, A. R., Christensen, J. P. & Holst, P. J., 2009, In: Vaccine.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

Pilgaard, K., Jensen, C., Schou, J., Lyssenko, V., Wegner, L., Brøns, C., Vilsbøll, T., Hansen, T., Madsbad, S., Holst, J., Vølund, A., Poulsen, P., Groop, L., Pedersen, O., Vaag, A., Pilgaard, K., Jensen, C. B., Schou, J. H., Lyssenko, V., Wegner, L., & 10 othersBrøns, C., Vilsbøll, T., Hansen, T., Madsbad, S., Holst, J. M., Vølund, A., Poulsen, P., Groop, L., Pedersen, O. & Vaag, A., 1 Jul 2009, In: Diabetologia. 52, 7, p. 1298-307 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

108 Citations (Scopus)

Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4(+) T-cell-independent CD8(+) T-cell-mediated tumor control

Sorensen, M. R., Holst, P. J., Pircher, H., Christensen, J. P. & Thomsen, A. R., 2009, In: European Journal of Immunology.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

2008

A new anti-tumour vaccination strategy: Adenoviral vector encoding invariant chain linked to the tumour associated antigen

Sorensen, M. R., Holst, P. J., Christensen, J. P. & Thomsen, A. R., 2008, In: Scandinavian Journal of Immunology. 2, p. 213-213

Research output: Contribution to journal › Conference abstract in journal › Research

Fugleinfluenza og perspektiverne for vaccination mod pandemisk influenza

Translated title of the contribution: Avian influenza and perspectives on vaccination against pandemic influenzaHolst, P. J., Christensen, J. P. & Thomsen, A. R., 2008, In: Ugeskrift for læger. 170, 48, p. 3953-6 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

MHC class II-associated invariant chain linkage of antigen dramatically improves cell-mediated immunity induced by adenovirus vaccines

Holst, P. J., Mandrup Jensen, C. M., Orskov, C., Thomsen, A. R., Christensen, J. P. & Sørensen, M. R., 2008, In: Journal of Immunology. 180, 5, p. 3339-46 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

2007

CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis

Holst, P. J., Orskov, C., Qvortrup, K., Christensen, J. P. & Thomsen, A. R., 2007, In: Journal of Virology. 81, 18, p. 10101-12 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Rapid and sustained CD4(+) T-cell-independent immunity from adenovirus-encoded vaccine antigens

Holst, P. J., Bartholdy, C., Buus, A. S., Thomsen, A. R. & Christensen, J. P., 2007, In: Journal of General Virology. 88, Pt 6, p. 1708-16 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

2006

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

Rosenkilde, M. M., Benned-Jensen, T., Holst, P. J., Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, J. P., Schwartz, T. W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

79 Citations (Scopus)

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

Ugleholdt, R., Poulsen, M-L. H., Holst, P. J., Irminger, J-C., Orskov, C., Pedersen, J., Rosenkilde, M. M., Zhu, X., Steiner, D. F. & Holst, J. J., 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

2005

MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.

Bonnesen, B., Ørskov, C., Rasmussen, S., Holst, P. J., Christensen, J. P., Eriksen, K. W., Qvortrup, K., Odum, N. & Labuda, T., 2005, In: Blood. 106, 10, p. 3396-404 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Peter Johannes Holst

Research output

Search results