Research output per year
Research output per year
Personal profile
Primary fields of research
Morphogenesis and differentiation of the gastrointestinal mucosa.
Special focus is on the bioinformatics interpretation of alterations in molecular profiles (transcriptome, metabolome) during mucosal inflammation. The basic research using mouse models for intestinal inflammation is translated into applied research in inflammatory bowel diseases.
Current research
Rectal insulin as treatment for inflammatory bowel disease.
Using mouse models for colonic inflammation in combination with mouse genetics we have made the invention that colitis in mice can be treated using rectal instillation of insulin. We are currently doing basic research with the purpose of delineating the mechanism of action for rectal insulin. In addition we have initiated clinical collaborations with clinicians in Copenhagen and Zürich with the purpose to conduct proof of concept studies with ulcerative colitis patients
Collaborators
Professor Gerhard Rogler, University of Zürich
Professor Yulan Wang, Key Laboratory of Magnetic Resonance in Biological Systems
Wuhan Institute of Physics and Mathematics
Teaching
Director, ”Course in Head, Neck, the Locomotor System and the Peripheral Nervous System” for third semester medical students.
Development of new teaching concepts:
- “The Modern Anatomical Theater”
- “Q + A livestreamed sessions with student and teacher interactions”
- “Livestreamed Exam TV”
- “The digital x-ray library”
- “The digital anatomical museum”
CV
Jørgen Olsen M.D., DMSc
Date of birth : March, 1964
Nationality : Danish
Gender: Male
Current affiliation
Department of Molecular & Cellular Medicine
University of Copenhagen
The Panum Institute, bldg. 18.6
Blegdamsvej 3
DK 2200N Denmark
Education
| 1992 | Medical Doctor (cand. med.), University of Copenhagen |
| 1998 | Doctor Medicinae (DMSc), The Faculty of Health Sciences, University of Copenhagen |
Employments
| 1993 | Research assistant, Michaelsen Foundation, Department of Medical Biochemistry & Genetics, University of Copenhagen |
| 1994 | Assistant professor Department of Medical Biochemistry & Genetics, University of Copenhagen |
| 1995 | Intern, Department of Medical Gastroenterology, KAS Herlev University Hospital |
| 1995 | Assistant professor Department of Medical Biochemistry & Genetics, University of Copenhagen |
| 1997 | Alfred Benzon Investigator, INSERM U381, Strasbourg, France |
| 1998 | Associate professor, Department of Medical Biochemistry & Genetics, University of Copenhagen |
| 2007 | Associate professor, Department of Cellular & Molecular Medicine, University of Copenhagen |
| 2009 | Professor, Department of Cellular & Molecular Medicine, University of Copenhagen |
Scholarships
| 1987 | Scholarstipend Danish Medical Research Council |
| 1988 | Scholarstipend The Faculty of Health Sciences, University of Copenhagen |
Administrative tasks
| Period | Task | Organisation |
| 1987-1990 | Executive committee, Institute of Medical Biochemistry C, Student representative | University of Copenhagen |
| 1994-1996 | Leader of the molecular Biology course for Human Biology students | University of Copenhagen |
| 1998-1999 | Member of "Samarbejdsudvalget", Department of Medical Biochemistry & Genetics | University of Copenhagen |
| 1999-2002 | Member of the Research Committee, The Faculty of Health Sciences | University of Copenhagen |
| 2001- | Leader of the course in Neurobiochemistry for Medical students | University of Copenhagen |
| 2003- | Member of the scientific board for the Journal of the Danish Medical Association (Ugeskrift for Læger) | Danish Medical Association |
| 2003-2005 | Member of the executive committee, The Research Committee, The faculty of Health Sciences | University of Health Sciences |
| 2005- | Teaching Coordinator, Department of Medical Biochemistry & Genetics | University of Copenhagen |
| 2007- | Member of the study board for medicine, Faculty of Healths Sciences | University of Copenhagen |
| 2007- | Member of the editorial board for "The Open Applied Informatics Journal" | Bentham Science Publishers Ltd |
Reviewing activity
| Journal |
| Bioinformatics |
| International Journal of Cancer |
| Journal of Oral Pathology & Medicine |
| European Journal of Biochemistry |
| Gastroenterology |
| European Journal of Human Genetics |
| Journal of Histochemistry & Cytochemistry |
| Ugeskrift for Læger |
| Oncogene |
| American Journal of Physiology |
| Cancer Letters |
| European Journal of Gastroenterology & Hepatology |
| Clinical Experimental Immunology |
Supervision and evaluation committees
Supervisor for 7 PhD students, 12 masters students and 2 scholar stipend students.
In the evaluation committee for one professorship, two associate professorships, 13 PhD theses and 5 masters theses.
External grants
| Project period | Amount | Currency | Project title | Source |
| 1998-1999 | 260000 | DKK | Cytokine mediated interaction between intestinal endoderm and mesenchyme | The Novo Nordisk Foundation |
| 1999-2000 | 75000 | DKK | Identification of markers for intestinal epithelial stem cells | The Novo Nordisk Foundation |
| 2000-2002 | 1050000 | DKK | Development and maintenance of the gastrointestinal mucosa | The Danish Medical Research Council |
| 2002 | 300000 | DKK | Gene expression as predictor for development of colorectal cancer | The Alfred Nielsen and Wife's Foundation |
| 2001-2002 | 200000 | DKK | Identification of gene combinations which increases the risk for colorectal cancer development | The Novo Nordisk Foundation |
| 2003-2004 | 600000 | DKK | Gene expression and cellular phenotype in the small intestinal epithelium | The Medical Research Council |
| 2003 | 125000 | DKK | Gene expression as predictor for development of colorectal cancer | The Alfred Nielsen and Wife's Foundation |
| 2004 | 125000 | DKK | Gene expression as predictor for development of colorectal cancer | The Alfred Nielsen and Wife's Foundation |
| 2004-2006 | 1080000 | DKK | Delineation of transcription factor networks for use in molecular gastroenterology | The Danish Medical Research Council |
| 2006-2007 | 96100 | EUR | Fruit Quality and Safety, ISAFRUIT. Partner. | European commission |
| 2006-2009 | 510000 | DKK | "samfinancieret ph.d-stip" | The Danish Medical Research Council |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Bioinformatics
- Gene expression analysis
- Intestinal differentiation
- Inflammatory bowel diseases
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- 6 Similar Profiles
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Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice
Yassin, M., Sadowska, Z., Djurhuus, D., Nielsen, B., Tougaard, P., Olsen, J. & Pedersen, A. E., 2019, In: Immunology. 158, 1, p. 35-46 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rectal insulin instillation inhibits inflammation and tumor development in chemically-induced colitis
Yassin, M., Sadowska, Z., Tritsaris, K., Kissow, H., Hansen, C. H. F., Forman, J. L., Rogler, G., Troelsen, J. T., Pedersen, A. E. & Olsen, J., 1 Dec 2018, In: Journal of Crohn's and Colitis. 12, 12, p. 1459–1474 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Turning Microscopy in the Medical Curriculum Digital: Experiences from The Faculty of Health and Medical Sciences at University of Copenhagen
Vainer, B., Mortensen, N. W., Poulsen, S. S., Sørensen, A. H., Olsen, J., Saxild, H. H. & Johansen, F. F., 2017, In: Journal of Pathology Informatics. 8, 10 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
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CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer
Olsen, J., Eiholm, S., Kirkeby, L. T., Espersen, M. L. M., Jess, P., Gögenür, I., Olsen, J. & Troelsen, J. T., 1 Feb 2016, In: Experimental and Molecular Pathology. 100, 1, p. 59-66 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High interleukin-6 mRNA expression is a predictor of relapse in colon cancer
Olsen, J., Kirkeby, L. T., Olsen, J., Eiholm, S., Jess, P., Gögenur, I. & Troelsen, J. T., 1 Apr 2015, In: Anticancer Research. 35, 4, p. 2235-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
17 Citations (Scopus) -
Integrative Transcriptomic and Metabonomic Molecular Profiling of Colonic Mucosal Biopsies Indicates a Unique Molecular Phenotype for Ulcerative Colitis
Rantalainen, M., Bjerrum, J. T., Olsen, J., Nielsen, O. H. & Wang, Y., 2 Jan 2015, In: Journal of Proteome Research. 14, 1, p. 479-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessment of the validity of a multigene analysis in the diagnostics of inflammatory bowel disease
Bjerrum, J. T., Nyberg, C., Olsen, J. & Nielsen, O. H., May 2014, In: Journal of Internal Medicine. 275, 5, p. 484-93 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2
Boyd, M., Coskun, M., Lilje, B., Andersson, R., Hoof, I., Lange, J. B., Dahlgaard, K., Olsen, J., Vitezic, M., Bjerrum, J. T., Seidelin, J. B., Nielsen, O. H., Troelsen, J. & Sandelin, A. G., 1 Dec 2014, In: D N A Research. 21, 6, p. 569-583 15 p.Research output: Contribution to journal › Journal article › Research › peer-review