Research output per year
Research output per year
Personal profile
Short presentation
Research in Copenhagen Hepatitis C Program (CO-HEP) focuses on basic studies of the hepatitis C virus life cycle with important clinical implications. The aim is to contribute to the development of better therapies and vaccines. Worldwide, over 150 million people are chronically infected with hepatitis C virus, with increased risk of developing liver cirrhosis and cancer, and 500 thousand people die annually from this disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Hepatitis C
- Vaccine
- Virology
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Dive into the research topics where Jens Bukh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants
Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H. & Bukh, J. & 1 others, , Sept 2019, In: Hepatology. 70, 3, p. 771-787 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Full-length open reading frame amplification of hepatitis C virus
Fahnøe, U. & Bukh, J., 2019, Hepatitis C Virus Protocols. Humana Press, p. 85-91 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome sequence of an unknown subtype of hepatitis C virus genotype 6: Another piece for the taxonomic puzzle
Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, J. & Schønning, K., 2019, In: Microbiology resource announcements. 8, 42, e01030-19.Research output: Contribution to journal › Journal article › Research › peer-review
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HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape
Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., Mar 2019, In: Journal of Hepatology. 70, 3, p. 388-397Research output: Contribution to journal › Journal article › Research › peer-review
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HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen
Filskov, J., Andersen, P., Agger, E. M. & Bukh, J., 2019, In: Scientific Reports. 9, 1, 13 p., 14085.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance
Velázquez-moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Jan 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79Research output: Contribution to journal › Journal article › Research › peer-review