Research output per year
Research output per year
Personal profile
Short presentation
The VLP group (VAR2CSA team) is using a virus-like-particle (VLP) based platform to adjuvant antigens for vaccine purposes. I am involved in vaccine production, formulation, quality assessment and immunization as well as development and optimization of our adjuvanting VLP system.
During my education I have been involved in preclinical studies with different VLP platforms designed to adjuvant low immunogenic antigens especially related to malaria. As a postdoc, I have been involved in using the VLP platform as an immunotherapeutic treatment for HER2 related breast cancer in mice. Several techniques are involved in this process such as; cloning and purification of proteins and VLPs, electron microscopy and dynamic light scattering for quality assessment as well as immunoassays to assess the response to the vaccine.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
AdaptVac ApS
1 Nov 2017 → …
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Research output
- 9 Journal article
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A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine
Janitzek, C. M., Peabody, J., Thrane, S., H R Carlsen, P., G Theander, T., Salanti, A., Chackerian, B., A Nielsen, M. & Sander, A. F., 1 Dec 2019, In: Scientific Reports. 9, 1, 10 p., 5260.Research output: Contribution to journal › Journal article › Research › peer-review
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Pfs230 and Pfs48/45 fusion proteins elicit strong transmission-blocking antibody responses against Plasmodium falciparum
Singh, S. K., Thrane, S., Chourasia, B. K., Teelen, K., Graumans, W., Stoter, R., van Gemert, G-J., van de Vegte-Bolmer, M. G., Nielsen, M. A., Salanti, A., Sander, A. F., Sauerwein, R. W., Jore, M. M. & Theisen, M., 2019, In: Frontiers in Immunology. 10, p. 1256Research output: Contribution to journal › Journal article › Research › peer-review
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Virus-like particle display of HER2 induces potent anti-cancer responses
Palladini, A., Thrane, S., Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, T. M., Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, T. G., Nielsen, M. A., Salanti, A., Lollini, P-L., Nanni, P. & Sander, A. F., 4 Mar 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.Research output: Contribution to journal › Journal article › Research › peer-review
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A VAR2CSA:CSP conjugate capable of inducing dual specificity antibody responses
Matondo, S., Thrane, S., Janitzek, C. M., Kavishe, R. A., Mwakalinga, S. B., Theander, T. G., Salanti, A., Nielsen, M. A. & Pedersen, A. F. S., 2017, In: African Health Sciences. 17, 2, p. 373-381 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display
Singh, S. K., Thrane, S., Janitzek, C. M., Nielsen, M. A., Theander, T. G., Theisen, M., Salanti, A. & Sander, A. F., 27 Jun 2017, In: Vaccine. 35, 30, p. 3726-3732 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
Thrane, S., Janitzek, C. M., Matondo, S., dos Santos Marques Resende, M., Gustavsson, T., De Jongh, W. A., Clemmensen, S., Roeffen, W., van de Vegte-Bolmer, M., van Gemert, G. J., Sauerwein, R., Schiller, J. T., Nielsen, M. A., Theander, T. G., Salanti, A. & Pedersen, A. F. S., 27 Apr 2016, In: Journal of Nanobiotechnology. 14, 16 p., 30.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial superglue generates a full-length circumsporozoite protein virus-like particle vaccine capable of inducing high and durable antibody responses
Janitzek, C. M., Matondo, S., Thrane, S., Nielsen, M. A., Kavishe, R., Mwakalinga, S. B., Theander, T. G., Salanti, A. & Pedersen, A. F. S., 8 Nov 2016, In: Malaria Journal. 15, 9 p., 545.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel virus-like particle based vaccine platform displaying the placental malaria antigen VAR2CSA
Thrane, S., Janitzek, C. M., Agerbæk, M. Ø., Ditlev, S. B., dos Santos Marques Resende, M., Nielsen, M. A., Theander, T. G., Salanti, A. & Pedersen, A. F. S., 1 Nov 2015, In: PloS one. 10, 11, 16 p., e0143071.Research output: Contribution to journal › Journal article › Research › peer-review