Research output per year
Research output per year
Search results
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2018
The tumor suppressor CIC directly regulates MAPK pathway genes via histone deacetylation
Weissmann, S., Cloos, P. A., Sidoli, S., Jensen, O. N., Pollard, S. & Helin, K., 1 Aug 2018, In: Cancer Research. 78, 15, p. 4114-4125 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2014
The Demethylase JMJD2C Localizes to H3K4me3 Positive Transcription Start Sites and Is Dispensable for Embryonic Development
Pedersen, M. T., Agger, K., Laugesen, A., Johansen, J. V., Cloos, P. A. C., Christensen, J. A. & Helin, K., Mar 2014, In: Molecular and Cellular Biology.Research output: Contribution to journal › Journal article › Research › peer-review
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2013
Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro
Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, J. L. & Clausen, R. P., 2 Jul 2013, In: P L o S One. 8, 7, p. e67653Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus) -
2012
Identification of catechols as histone-lysine demethylase inhibitors
Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, M. & Olsen, L., 24 Apr 2012, In: F E B S Letters. 586, 8, p. 1190-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor
Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, J. S., Helin, K., Olsen, L. & Gajhede, M., Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914Research output: Contribution to journal › Journal article › Research › peer-review
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2011
Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors
Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, M., Clausen, R. P. & Kristensen, J. L., 19 Sept 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103Research output: Contribution to journal › Journal article › Research › peer-review
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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J. & Helin, K., 19 May 2011, In: Nature. 473, 7347, p. 343-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Role of Histone Demethylases in Disease
Cloos, P. A. C., 2011, Epigenetic Aspects of Chronic Diseases. Roach, H., Bronner, F. & Oreffo, R. (eds.). Springer, p. 75-93 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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2010
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Pasini, D., Cloos, P. A. C., Walfridsson, J., Olsson, L., Bukowski, J.-P., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J. & Helin, K., 11 Mar 2010, In: Nature. 464, 7286, p. 306-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2009
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
Agger, K., Cloos, P. A. C., Rudkjaer, L., Williams, K., Andersen, G., Christensen, J. & Helin, K., 2009, In: Genes & Development. 23, 10, p. 1171-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2008
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Pasini, D., Hansen, K. H., Christensen, J., Agger, K., Cloos, P. A. C. & Helin, K., 2008, In: Genes & Development. 22, 10, p. 1345-55 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
Cloos, P. A. C., Christensen, J., Agger, K. & Helin, K., 2008, In: Genes & Development. 22, 9, p. 1115-40 25 p.Research output: Contribution to journal › Review › peer-review
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Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases
Pasini, D., Bracken, A. P., Agger, K., Christensen, J. A., Hansen, K., Cloos, P. A. C. & Helin, K., 2008, In: Cold Spring Harbor Symposia on Quantitative Biology. 73, p. 253-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The emerging functions of histone demethylases.
Agger, K., Christensen, J., Cloos, P. A. & Helin, K., 2008, In: Current Opinion in Genetics & Development. 18, 2, p. 159-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2007
Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
Wägner, A. M., Cloos, P., Bergholdt, R., Boissy, P., Andersen, T. L., Henriksen, D. B., Christiansen, C., Christgau, S., Pociot, F. & Nerup, J., 2007, In: Diabetologia. 50, 3, p. 676-81 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Christensen, J., Agger, K., Cloos, P. A. C., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K., Salcini, A. E. & Helin, K., 2007, In: Cell. 128, 6, p. 1063-76 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Agger, K., Cloos, P. A. C., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E. & Helin, K., 2007, In: Nature. 449, 7163, p. 731-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2006
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Cloos, P. A. C., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K. H. & Helin, K., 2006, In: Nature. 442, 7100, p. 307-11 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2005
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Christensen, J., Cloos, P., Toftegaard, U., Klinkenberg, D., Bracken, A. P., Trinh, E., Heeran, M., Di Stefano, L. & Helin, K., 2005, In: Nucleic Acids Research. 33, 17, p. 5458-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.
Deberg, M., Labasse, A., Christgau, S., Cloos, P., Bang Henriksen, D., Chapelle, J.-P., Zegels, B., Reginster, J.-Y. & Henrotin, Y., 2005, In: Osteoarthritis and Cartilage. 13, 3, p. 258-65 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sex hormones in the regulation of bone and cartilage metabolism: an old paradigm and a new challenge.
Christgau, S. & Cloos, P. A. C., 2005, In: Minerva Ginecologica. 57, 6, p. 611-7 6 p.Research output: Contribution to journal › Review
3 Citations (Scopus) -
2004
An immunoassay for measuring fragments of newly synthesized collagen type I produced during metastatic invasion of bone.
Cloos, P. A. C., Lyubimova, N., Solberg, H., Qvist, P., Christiansen, C., Byrjalsen, I. & Christgau, S., 2004, In: Clinical Laboratory. 50, 5-6, p. 279-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
46 Citations (Scopus) -
Characterization of aged osteocalcin fragments derived from bone resorption.
Cloos, P. A. C. & Christgau, S., 2004, In: Clinical Laboratory. 50, 9-10, p. 585-98 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
26 Citations (Scopus) -
Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone.
Alexandersen, P., Peris, P., Guañabens, N., Byrjalsen, I., Alvarez, L., Solberg, H. & Cloos, P. A., 2004, In: Journal of Bone and Mineral Research. 20, 4, p. 588-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Post-translational modifications of proteins: implications for aging, antigen recognition, and autoimmunity.
Cloos, P. A. C. & Christgau, S., 2004, In: Biogerontology. 5, 3, p. 139-58 19 p.Research output: Contribution to journal › Review
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Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).
Christgau, S., Tankó, L. B., Cloos, P. A. C., Mouritzen, U., Christiansen, C., Delaissé, J.-M. & Høegh-Andersen, P., 2004, In: Menopause . 11, 5, p. 508-18 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
102 Citations (Scopus) -
2003
Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments.
Cloos, P. A. C., Christgau, S., Lyubimova, N., Body, J.-J., Qvist, P. & Christiansen, C., 2003, In: Breast cancer research : BCR. 5, 4, p. R103-9Research output: Contribution to journal › Journal article › Research › peer-review
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Current and future applications of bone turnover markers.
Christgau, S. & Cloos, P. A. C., 2003, In: Clinical Laboratory. 49, 9-10, p. 439-46 7 p.Research output: Contribution to journal › Review
11 Citations (Scopus) -
2002
Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products.
Lehmann, H. J., Mouritzen, U., Christgau, S., Cloos, P. A. C. & Christiansen, C., 2002, In: Annals of the Rheumatic Diseases. 61, 6, p. 530-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
73 Citations (Scopus) -
Investigation of bone disease using isomerized and racemized fragments of type I collagen.
Cloos, P. A. C., Fledelius, C., Christgau, S., Christiansen, C., Engsig, M., Delmas, P., Body, J.-J. & Garnero, P., 2002, In: Calcified Tissue International. 72, 1, p. 8-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-enzymatic covalent modifications of proteins: mechanisms, physiological consequences and clinical applications.
Cloos, P. A. C. & Christgau, S., 2002, In: Matrix Biology. 21, 1, p. 39-52 13 p.Research output: Contribution to journal › Review
76 Citations (Scopus) -
Type I collagen racemization and isomerization and the risk of fracture in postmenopausal women: the OFELY prospective study.
Garnero, P., Cloos, P., Sornay-Rendu, E., Qvist, P. & Delmas, P. D., 2002, In: Journal of Bone and Mineral Research. 17, 5, p. 826-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
98 Citations (Scopus) -
2000
Age-related de-phosphorylation of proteins in dentin: a biological tool for assessment of protein age.
Cloos, P. A. & Jensen, A. L., 2000, In: Biogerontology. 1, 4, p. 341-56 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
35 Citations (Scopus) -
Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.
Cloos, P. A. & Fledelius, C., 2000, In: Biochemical Journal. 345 Pt 3, p. 473-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
128 Citations (Scopus) -
Racemization and isomerization of type I collagen C-telopeptides in human bone and soft tissues: assessment of tissue turnover.
Gineyts, E., Cloos, P. A., Borel, O., Grimaud, L., Delmas, P. D. & Garnero, P., 2000, In: Biochemical Journal. 345 Pt 3, p. 481-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
79 Citations (Scopus) -
1997
Characterization of urinary degradation products derived from type I collagen. Identification of a beta-isomerized Asp-Gly sequence within the C-terminal telopeptide (alpha1) region.
Fledelius, C., Johnsen, A. H., Cloos, P. A., Bonde, M. & Qvist, P., 1997, In: Journal of Biological Chemistry. 272, 15, p. 9755-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
170 Citations (Scopus)