Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Paul A C Cloos; Jesper Christensen; Karl Agger; Kristian Helin

doi:10.1101/gad.1652908

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Paul A C Cloos, Jesper Christensen, Karl Agger, Kristian Helin

501 Citations (Scopus)

Abstract

The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer.

Original language	English
Journal	Genes & Development
Volume	22
Issue number	9
Pages (from-to)	1115-40
Number of pages	25
ISSN	0890-9369
DOIs	https://doi.org/10.1101/gad.1652908
Publication status	Published - 2008

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title = "Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.",

abstract = "The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer.",

author = "Cloos, {Paul A C} and Jesper Christensen and Karl Agger and Kristian Helin",

note = "Keywords: Aging; Animals; Cell Differentiation; Histones; Humans; Methylation; Models, Biological; Neoplasms; Oxidoreductases, N-Demethylating; Phylogeny",

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T1 - Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

AU - Cloos, Paul A C

AU - Christensen, Jesper

AU - Agger, Karl

AU - Helin, Kristian

N1 - Keywords: Aging; Animals; Cell Differentiation; Histones; Humans; Methylation; Models, Biological; Neoplasms; Oxidoreductases, N-Demethylating; Phylogeny

PY - 2008

Y1 - 2008

N2 - The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer.

AB - The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer.

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EP - 1140

JO - Genes & Development

JF - Genes & Development

IS - 9

ER -

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Abstract

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