Paul Cloos

Publikation

Publikationer pr. år 1997 2000 2002 2004 2005 2007 2008 2011 2018

• 30 Tidsskriftartikel
• 5 Review
• 1 Bidrag til bog/antologi

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2018

  The tumor suppressor CIC directly regulates MAPK pathway genes via histone deacetylation

  Weissmann, S., Cloos, P. A., Sidoli, S., Jensen, O. N., Pollard, S. & Helin, K., 1 aug. 2018, I: Cancer Research. 78, 15, s. 4114-4125 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Histones 100%
  • Oligodendroglioma 70%
  • Genes 42%
  • Sin3 Histone Deacetylase and Corepressor Complex 36%
  • Neoplasms 34%
  19 Citationer (Scopus)
• 2014

  The Demethylase JMJD2C Localizes to H3K4me3 Positive Transcription Start Sites and Is Dispensable for Embryonic Development

  Pedersen, M. T., Agger, K., Laugesen, A., Johansen, J. V., Cloos, P. A. C., Christensen, J. A. & Helin, K., mar. 2014, I: Molecular and Cellular Biology.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • histone H3 trimethyl Lys4 100%
  • Transcription Initiation Site 80%
  • Tudor Domain 79%
  • Embryonic Development 64%
  • Histone Demethylases 33%
  47 Citationer (Scopus)
• 2013

  Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

  Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, J. L. & Clausen, R. P., 2 jul. 2013, I: P L o S One. 8, 7, s. e67653

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • histone demethylases 100%
  • Histone Demethylases 88%
  • Substrate 70%
  • post-translational modification 63%
  • Post Translational Protein Processing 62%
  18 Citationer (Scopus)
• 2012

  Identification of catechols as histone-lysine demethylase inhibitors

  Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, M. & Olsen, L., 24 apr. 2012, I: F E B S Letters. 586, 8, s. 1190-4 5 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Catechols 100%
  • Histone Demethylases 88%
  • Catechol 61%
  • Occurrence in Nature 50%
  • catechol 42%
  29 Citationer (Scopus)

• Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

  Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, J. S., Helin, K., Olsen, L. & Gajhede, M., jun. 2012, I: F E B S Journal. 279, 11, s. 1905-1914

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • 2,4-pyridinedicarboxylic acid 100%
  • H3K4Me3 86%
  • Histone Demethylases 67%
  • histone H3 trimethyl Lys4 66%
  • Jumonji Domain-Containing Histone Demethylases 58%
  51 Citationer (Scopus)
• 2011

  Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

  Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, M., Clausen, R. P. & Kristensen, J. L., 19 sep. 2011, I: Angewandte Chemie International Edition. 50, 39, s. 9100-9103

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Amino acids 100%
  • Histone 90%
  • Lysine 79%
  • Amino-Acid Residue 75%
  • Substrates 58%
  30 Citationer (Scopus)

• TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

  Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J. & Helin, K., 19 maj 2011, I: Nature. 473, 7347, s. 343-8 6 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Cytosine 100%
  • DNA Methylation 82%
  • Transcription Initiation Site 64%
  • Co-Repressor Proteins 35%
  • Genes 33%
  723 Citationer (Scopus)

• The Role of Histone Demethylases in Disease

  Cloos, P. A. C., 2011, Epigenetic Aspects of Chronic Diseases. Roach, HI., Bronner, F. & Oreffo, ROC. (red.). Springer, s. 75-93 17 s.

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review
• 2010

  JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

  Pasini, D., Cloos, P. A. C., Walfridsson, J., Olsson, L., Bukowski, J-P., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J. & Helin, K., 11 mar. 2010, I: Nature. 464, 7286, s. 306-10 4 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Polycomb Repressive Complex 2 100%
  • Polycomb-Group Proteins 97%
  • Genes 26%
  • Mouse Embryonic Stem Cells 16%
  • Essential Genes 14%
  401 Citationer (Scopus)
• 2009

  The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

  Agger, K., Cloos, P. A. C., Rudkjaer, L., Williams, K., Andersen, G., Christensen, J. & Helin, K., 2009, I: Genes & Development. 23, 10, s. 1171-6 5 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Oncogenes 100%
  • Tumor Suppressor Protein p14ARF 79%
  • Fibroblasts 78%
  • Cellular Senescence 57%
  • Diploidy 57%
  317 Citationer (Scopus)
• 2008

  Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

  Pasini, D., Hansen, K. H., Christensen, J., Agger, K., Cloos, P. A. C. & Helin, K., 2008, I: Genes & Development. 22, 10, s. 1345-55 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Polycomb Repressive Complex 2 100%
  • Mouse Embryonic Stem Cells 40%
  • Polycomb-Group Proteins 24%
  • histone H3 trimethyl Lys4 23%
  • Developmental Genes 22%
  243 Citationer (Scopus)

• Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

  Cloos, P. A. C., Christensen, J., Agger, K. & Helin, K., 2008, I: Genes & Development. 22, 9, s. 1115-40 25 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Histone Demethylases 100%
  • Histones 64%
  • Methylation 62%
  • Histone Methyltransferases 31%
  • Multiprotein Complexes 30%
  501 Citationer (Scopus)

• Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases

  Pasini, D., Bracken, A. P., Agger, K., Christensen, J. A., Hansen, K., Cloos, P. A. C. & Helin, K., 2008, I: Cold Spring Harbor Symposia on Quantitative Biology. 73, s. 253-63 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Histone Demethylases 100%
  • Histone Methyltransferases 94%
  • Developmental 83%
  • Histone 73%
  • Cell Differentiation 55%
  38 Citationer (Scopus)

• The emerging functions of histone demethylases.

  Agger, K., Christensen, J., Cloos, P. A. & Helin, K., 2008, I: Current Opinion in Genetics & Development. 18, 2, s. 159-68 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Histone Demethylases 100%
  • Epigenomics 60%
  • Histones 48%
  • Methylation 46%
  • Lysine 33%
  176 Citationer (Scopus)
• 2007

  Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?

  Wägner, A. M., Cloos, P., Bergholdt, R., Boissy, P., Andersen, T. L., Henriksen, D. B., Christiansen, C., Christgau, S., Pociot, F. & Nerup, J., 2007, I: Diabetologia. 50, 3, s. 676-81 5 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Protein D-Aspartate-L-Isoaspartate Methyltransferase 100%
  • dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine 66%
  • Post Translational Protein Processing 55%
  • Type 1 Diabetes Mellitus 47%
  • Enzymes 29%
  13 Citationer (Scopus)

• RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

  Christensen, J., Agger, K., Cloos, P. A. C., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K., Salcini, A. E. & Helin, K., 2007, I: Cell. 128, 6, s. 1063-76 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • histone H3 trimethyl Lys4 100%
  • H3K4Me3 77%
  • Histone 74%
  • Lysine 67%
  • Histone Demethylases 67%
  390 Citationer (Scopus)

• UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

  Agger, K., Cloos, P. A. C., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E. & Helin, K., 2007, I: Nature. 449, 7163, s. 731-4 3 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Polycomb Repressive Complex 2 100%
  • Histone Demethylases 94%
  • Histones 61%
  • Methylation 59%
  • Epigenomics 56%
  891 Citationer (Scopus)
• 2006

  The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.

  Cloos, P. A. C., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K. H. & Helin, K., 2006, I: Nature. 442, 7100, s. 307-11 4 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Lysine 100%
  • Oncogenes 97%
  • Histones 96%
  • Squamous Cell Carcinoma 85%
  • Genes 41%
  566 Citationer (Scopus)
• 2005

  Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.

  Christensen, J., Cloos, P., Toftegaard, U., Klinkenberg, D., Bracken, A. P., Trinh, E., Heeran, M., Di Stefano, L. & Helin, K., 2005, I: Nucleic Acids Research. 33, 17, s. 5458-70 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • E2F Transcription Factors 100%
  • Cell Cycle 80%
  • DNA 56%
  • cdc Genes 43%
  • Retinoblastoma Protein 43%
  116 Citationer (Scopus)

• New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.

  Deberg, M., Labasse, A., Christgau, S., Cloos, P., Bang Henriksen, D., Chapelle, J-P., Zegels, B., Reginster, J-Y. & Henrotin, Y., 2005, I: Osteoarthritis and Cartilage. 13, 3, s. 258-65 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • (NO2)Tyr(111)-collagen type II (108-116) 100%
  • Collagen 54%
  • Peptides 54%
  • Cartilage 54%
  • Collagen Type II 48%
  111 Citationer (Scopus)

• Sex hormones in the regulation of bone and cartilage metabolism: an old paradigm and a new challenge.

  Christgau, S. & Cloos, P. A. C., 2005, I: Minerva Ginecologica. 57, 6, s. 611-7 6 s.

  Publikation: Bidrag til tidsskrift › Review

  • Gonadal Steroid Hormones 100%
  • Cartilage 80%
  • Estrogens 75%
  • Bone and Bones 54%
  • Selective Estrogen Receptor Modulators 44%
  3 Citationer (Scopus)
• 2004

  An immunoassay for measuring fragments of newly synthesized collagen type I produced during metastatic invasion of bone.

  Cloos, P. A. C., Lyubimova, N., Solberg, H., Qvist, P., Christiansen, C., Byrjalsen, I. & Christgau, S., 2004, I: Clinical Laboratory. 50, 5-6, s. 279-89 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Collagen Type I 100%
  • Immunoassay 99%
  • Collagen 94%
  • Marker 87%
  • Epitope 67%
  46 Citationer (Scopus)

• Characterization of aged osteocalcin fragments derived from bone resorption.

  Cloos, P. A. C. & Christgau, S., 2004, I: Clinical Laboratory. 50, 9-10, s. 585-98 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Antiresorptive 100%
  • Osteocalcin 61%
  • Bone Resorption 57%
  • Marker 49%
  • Immunoaffinity Chromatography 37%
  26 Citationer (Scopus)

• Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone.

  Alexandersen, P., Peris, P., Guañabens, N., Byrjalsen, I., Alvarez, L., Solberg, H. & Cloos, P. A., 2004, I: Journal of Bone and Mineral Research. 20, 4, s. 588-95 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Osteitis Deformans 100%
  • collagen type I trimeric cross-linked peptide 94%
  • Collagen Type I 40%
  • Bone Remodeling 30%
  • tiludronic acid 18%
  38 Citationer (Scopus)

• Post-translational modifications of proteins: implications for aging, antigen recognition, and autoimmunity.

  Cloos, P. A. C. & Christgau, S., 2004, I: Biogerontology. 5, 3, s. 139-58 19 s.

  Publikation: Bidrag til tidsskrift › Review

  • Post Translational Protein Processing 100%
  • Autoimmunity 94%
  • Antigens 61%
  • Autoimmune Diseases 42%
  • Immune System 38%
  119 Citationer (Scopus)

• Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).

  Christgau, S., Tankó, L. B., Cloos, P. A. C., Mouritzen, U., Christiansen, C., Delaissé, J-M. & Høegh-Andersen, P., 2004, I: Menopause . 11, 5, s. 508-18 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • levormeloxifene 100%
  • Selective Estrogen Receptor Modulators 64%
  • Cartilage 42%
  • Estrogens 39%
  • Osteoarthritis 14%
  102 Citationer (Scopus)
• 2003

  Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments.

  Cloos, P. A. C., Christgau, S., Lyubimova, N., Body, J-J., Qvist, P. & Christiansen, C., 2003, I: Breast cancer research : BCR. 5, 4, s. R103-9

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Collagen Type I 100%
  • Breast Neoplasms 63%
  • Neoplasm Metastasis 61%
  • Bone and Bones 59%
  • Protein Isoforms 16%
  23 Citationer (Scopus)

• Current and future applications of bone turnover markers.

  Christgau, S. & Cloos, P. A. C., 2003, I: Clinical Laboratory. 49, 9-10, s. 439-46 7 s.

  Publikation: Bidrag til tidsskrift › Review

  11 Citationer (Scopus)
• 2002

  Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products.

  Lehmann, H. J., Mouritzen, U., Christgau, S., Cloos, P. A. C. & Christiansen, C., 2002, I: Annals of the Rheumatic Diseases. 61, 6, s. 530-3 3 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Collagen Type II 100%
  • Diphosphonates 93%
  • Collagen 80%
  • Degradation Product 80%
  • Cartilage 74%
  73 Citationer (Scopus)

• Investigation of bone disease using isomerized and racemized fragments of type I collagen.

  Cloos, P. A. C., Fledelius, C., Christgau, S., Christiansen, C., Engsig, M., Delmas, P., Body, J-J. & Garnero, P., 2002, I: Calcified Tissue International. 72, 1, s. 8-17 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Bone Neoplasms 100%
  • Bone Diseases 90%
  • Bone Remodeling 83%
  • Collagen Type I 81%
  • collagen type I trimeric cross-linked peptide 72%
  27 Citationer (Scopus)

• Non-enzymatic covalent modifications of proteins: mechanisms, physiological consequences and clinical applications.

  Cloos, P. A. C. & Christgau, S., 2002, I: Matrix Biology. 21, 1, s. 39-52 13 s.

  Publikation: Bidrag til tidsskrift › Review

  • Proteins 100%
  76 Citationer (Scopus)

• Type I collagen racemization and isomerization and the risk of fracture in postmenopausal women: the OFELY prospective study.

  Garnero, P., Cloos, P., Sornay-Rendu, E., Qvist, P. & Delmas, P. D., 2002, I: Journal of Bone and Mineral Research. 17, 5, s. 826-33 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Collagen Type I 100%
  • Prospective Studies 63%
  • Bone Density 45%
  • Alkaline Phosphatase 35%
  • Protein Isoforms 32%
  98 Citationer (Scopus)
• 2000

  Age-related de-phosphorylation of proteins in dentin: a biological tool for assessment of protein age.

  Cloos, P. A. & Jensen, A. L., 2000, I: Biogerontology. 1, 4, s. 341-56 15 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Dentin 100%
  • Phosphorylation 65%
  • Collagen 48%
  • Proteins 35%
  • Amino Acids 33%
  35 Citationer (Scopus)

• Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.

  Cloos, P. A. & Fledelius, C., 2000, I: Biochemical Journal. 345 Pt 3, s. 473-80 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Biological Clocks 100%
  • Bone Resorption 70%
  • Collagen 65%
  • Urine 49%
  • Osteoporosis 30%
  128 Citationer (Scopus)

• Racemization and isomerization of type I collagen C-telopeptides in human bone and soft tissues: assessment of tissue turnover.

  Gineyts, E., Cloos, P. A., Borel, O., Grimaud, L., Delmas, P. D. & Garnero, P., 2000, I: Biochemical Journal. 345 Pt 3, s. 481-5 4 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • collagen type I trimeric cross-linked peptide 100%
  • Collagen Type I 74%
  • Collagen 70%
  • Isomerization 58%
  • Deoxypyridinoline 46%
  79 Citationer (Scopus)
• 1997

  Characterization of urinary degradation products derived from type I collagen. Identification of a beta-isomerized Asp-Gly sequence within the C-terminal telopeptide (alpha1) region.

  Fledelius, C., Johnsen, A. H., Cloos, P. A., Bonde, M. & Qvist, P., 1997, I: Journal of Biological Chemistry. 272, 15, s. 9755-63 8 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • beta-aspartylglycine 100%
  • Asp-Gly 86%
  • pyridinoline 71%
  • aspartylglycine 70%
  • Pyridinoline 51%
  170 Citationer (Scopus)