Karla Andrea Frydenvang

2019

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K. & Kastrup, J. S., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Functionalized Helical beta-Peptoids

Wellhofer, I., Frydenvang, K., Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, C. A., 5 Apr 2019, In: Journal of Organic Chemistry. 84, 7, p. 3762-3779

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, K., Barrera, N. P., Kastrup, J. S., Edwardson, J. M. & Bowie, D., 5 Jun 2019, In: Neuron. 102, 5, p. 976-+

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., May 2019, In: PLoS ONE. 14, 5, 15 p., e0217292.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

14 Downloads (Pure)

2018

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation.

Brogi, S., Brindisi, M., Butini, S., Kshirsagar, G., Maramai, S., Chemi, G., Gemma, S., Campiani, G., Novellino, E., Fiorenzani, P., Pinassi, J., Aloisi, A. M., Gynther, M., Venskutonyte, R., Han, L., Frydenvang, K. A., Kastrup, J. S. J. & Pickering, D. S., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 2124-2130 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, J. S. & Francotte, P., 11 Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2017

Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S. & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Lessons from crystal structures of kainate receptors

Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, K., Tung, T. T., Olsen, J., Nielsen, J. & Christensen, S. B., 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, T. N., Kastrup, J. S., Pickering, D. S. & Frydenvang, K. A., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors

Møllerud, S., Pinto, A., Marconi, L., Frydenvang, K. A., Thorsen, T. S., Laulumaa, S. K., Venskutonyte, R., Winther, N., Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, D. S. & Kastrup, J. S. J., 20 Sept 2017, In: A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2016

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

Krintel, C., Francotte, P., Pickering, D. S., Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, K. A., Goffin, E., Pirotte, B. & Kastrup, J. S. J., 7 Jun 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

Jensen, C. M., Chow, H-Q., Chen, M., Zhai, L., Frydenvang, K. A., Liu, H., Franzyk, H. & Christensen, S. B., 23 May 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, K. A., Pickering, D. S. & Kastrup, J. S. J., 6 Sept 2016, In: Structure. 24, 9, p. 1582-1589 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

Szymanska, E., Frydenvang, K. A., Pickering, D. S., Krintel, C., Nielsen, B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 14 Jan 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

Larsen, A. P., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D-H., Lestage, P., Danober, L., Pirotte, B. & Kastrup, J. S., 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

Wang, S-Y., Larsen, Y., Navarrete, C. V., Jensen, A. A., Nielsen, B., Al-Musaed, A., Frydenvang, K., Kastrup, J. S., Pickering, D. S. & Clausen, R. P., 10 Mar 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2015

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, K., Egebjerg, J., Kastrup, J. S. & Holm, M. M., 3 Dec 2015, In: Neuroscience. 310, p. 709-22 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 17 Jun 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Iminolactones from Schizophyllum commune

Liu, X., Frydenvang, K. A., Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, S. B., 22 May 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 22 Jul 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2014

Advances towards aromatic oligoamide foldamers: synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains

Hjelmgaard, T., Plesner, M., Dissing, M. M., Andersen, J. M., Frydenvang, K. A. & Nielsen, J., 2014, In: European Journal of Organic Chemistry. 2014, 19, p. 3971-3975 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

Jørgensen, L., Nielsen, B., Pickering, D. S., Kristensen, A. S., Frydenvang, K. A., Madsen, U. & Clausen, R. P., 24 Sept 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

Krintel, C., Frydenvang, K., Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, M., Pickering, D. S. & Kastrup, J. S., May 2014, In: F E B S Journal. p. 2422–2430 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 1 Oct 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides

Francotte, P., Nørholm, A-B., Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., de Tullio, P., Challal, S., Thomas, J-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S. J. & Pirotte, B., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9539-53 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2013

Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 28 Feb 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

På jagt efter et virkningssted i hjernen

Frydenvang, K. A., Juknaite, L. & Kastrup, J. S. J., 2013, In: Lægemiddelforskning. p. 50-52 3 p.

Research output: Contribution to journal › Journal article › Communication

Some transformations of tacrolimus, an immunosuppressive drug

Skytte, D. M., Jaroszewski, J. W., Johansen, K., Hansen, S. H., Hansen, L., G. Nielsen, P. & Frydenvang, K. A., 14 Feb 2013, In: European Journal of Pharmaceutical Sciences. 48, 3, p. 514-522 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Krintel, C., Harpsøe, K., Zachariassen, L. G., Peters, D., Frydenvang, K., Pickering, D. S., Gajhede, M. & Kastrup, J. S., Sept 2013, In: Acta crystallographica. Section D, Biological crystallography. 69, Pt 9, p. 1645-52 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, D. S., Frydenvang, K., Swanson, G. T., Kastrup, J. S. J. & Oikawa, M., 28 Mar 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

Nørholm, A-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, J. S., 14 Nov 2013, In: Journal of Medicinal Chemistry. 56, 21, p. 8736-45 10 p.

Research output: Contribution to journal › Journal article › Research

21 Citations (Scopus)

Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acid_A receptor agonists

Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, C. G., Nielsen, B., Kehler, J., Frydenvang, K., Kristensen, J., Balle, T., Jensen, A. A., Kristiansen, U. & Frølund, B., 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2012

Kainate induces various domain closures in AMPA and kainate receptors

Venskutonyte, R., Frydenvang, K., Hald, H., Rabassa, A. C. D., Gajhede, M., Ahring, P. K. & Kastrup, J. S., Sept 2012, In: Neurochemistry International. 61, 4, p. 536-545

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, B., Gajhede, M., Kastrup, J. S. J., Bunch, L., Frydenvang, K. & Pickering, D. S., Oct 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

Venskutonyte, R., Frydenvang, K., Valadés, E. A., Szymanska, E. M., Johansen, T. N., Kastrup, J. S. & Pickering, D. S., Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M. & Kastrup, J. S., 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

2011

A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

Szymanska, E., Frydenvang, K., Contreras-Sanz, A., Pickering, D. S., Frola, E., Serafimoska, Z., Nielsen, B., Kastrup, J. S. & Johansen, T. N., 27 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., Dec 2011, In: Journal of Structural Biology. 176, 3, p. 307-314

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta² -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors

Dallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., De Amici, M., Fucile, S., Piccari, V., Frydenvang, K. A., Pucci, L., Gotti, C., Clementi, F. & De Micheli, C., 2 May 2011, In: ChemMedChem. 6, 5, p. 889-903

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

Pøhlsgaard, J., Frydenvang, K. A., Madsen, U. & Kastrup, J. S., 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 135-150

Research output: Contribution to journal › Review › peer-review

61 Citations (Scopus)

Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, K. A., Kastrup, J. S. J., Novellino, E., Campiani, G. & Pickering, D. S., 14 Jul 2011, In: Journal of Medicinal Chemistry. 54, 13, p. 4793-4805

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

2010

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

Frydenvang, K. A., Pickering, D. S., Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, B., Vogensen, S. B., Hald, H., Kastrup, J. S., Krogsgaard-Larsen, P. & Clausen, R. P., 9 Dec 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

Koradia, V. S., Lopez de Diego, H., Frydenvang, K. A., Ringkjøbing-Elema, M., Müllertz, A., Bond, A. D. & Rantanen, J., 1 Dec 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

Bach, A., Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, K., Padrah, S., Christensen, S. B., Madsen, K. L., Weinstein, H., Gether, U. & Strømgaard, K., 7 Oct 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Karla Andrea Frydenvang

Research output

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