Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R Hassan; Salah M El-Kousy; Sayed A El-Toumy; Karla Frydenvang; Truong Thanh Tung; Jesper Olsen; John Nielsen; Søren Brøgger Christensen

doi:10.1021/acs.jnatprod.7b00106

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R Hassan, Salah M El-Kousy, Sayed A El-Toumy, Karla Frydenvang, Truong Thanh Tung, Jesper Olsen, John Nielsen, Søren Brøgger Christensen

2 Citations (Scopus)

Abstract

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

Original language	English
Journal	Journal of Natural Products
Volume	80
Pages (from-to)	2830-2834
Number of pages	5
ISSN	0163-3864
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00106
Publication status	Published - 27 Oct 2017

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Journal Article

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10.1021/acs.jnatprod.7b00106

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title = "Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula",

abstract = "A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.",

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AU - Hassan, Ahmed R

AU - El-Kousy, Salah M

AU - El-Toumy, Sayed A

AU - Frydenvang, Karla

AU - Tung, Truong Thanh

AU - Olsen, Jesper

AU - Nielsen, John

AU - Christensen, Søren Brøgger

PY - 2017/10/27

Y1 - 2017/10/27

N2 - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

AB - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

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SN - 0163-3864

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JO - Journal of Natural Products

JF - Journal of Natural Products

ER -

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

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