Iminolactones from Schizophyllum commune

Xuemei Liu; Karla Andrea Frydenvang; Huizhen Liu; Lin Zhai; Ming Chen; Carl Erik Olsen; Søren Brøgger Christensen

doi:10.1021/np500836y

Iminolactones from Schizophyllum commune

Xuemei Liu, Karla Andrea Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen

Section for Plant Biochemistry

10 Citations (Scopus)

Abstract

Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

Original language	English
Journal	Journal of Natural Products
Volume	78
Issue number	5
Pages (from-to)	1165-1168
Number of pages	4
ISSN	0974-5211
DOIs	https://doi.org/10.1021/np500836y
Publication status	Published - 22 May 2015

Keywords

Faculty of Health and Medical Sciences
Natural products
Iminolactones
Schizophyllum commune

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np500836y

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abstract = "Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.",

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doi = "10.1021/np500836y",

language = "English",

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T1 - Iminolactones from Schizophyllum commune

AU - Liu, Xuemei

AU - Frydenvang, Karla Andrea

AU - Liu, Huizhen

AU - Zhai, Lin

AU - Chen, Ming

AU - Olsen, Carl Erik

AU - Christensen, Søren Brøgger

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

AB - Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

KW - Faculty of Health and Medical Sciences

KW - Natural products

KW - Iminolactones

KW - Schizophyllum commune

U2 - 10.1021/np500836y

DO - 10.1021/np500836y

M3 - Journal article

C2 - 25951057

SN - 0974-5211

VL - 78

SP - 1165

EP - 1168

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Iminolactones from Schizophyllum commune

Abstract

Keywords

UN SDGs

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