Guillermo Montoya

2019

A Consensus Binding Motif for the PP4 Protein Phosphatase

Ueki, Y., Kruse, T., Weisser, M. B., Sundell, G. N., Larsen, M. S. Y., Mendez, B. L., Jenkins, N. P., Garvanska, D. H., Cressey, L., Zhang, G., Davey, N., Montoya, G., Ivarsson, Y., Kettenbach, A. N. & Nilsson, J., 19 Dec 2019, In: Molecular Cell.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

Slaymaker, I. M., Mesa, P., Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, S., Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, G. & Zhang, F., 26 Mar 2019, In: Cell Reports. 26, 13, p. 3741-3751.e5 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

10 Downloads (Pure)

Molecular architecture of the Jumonji C family histone demethylase KDM5B

Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, O., Lousen, R., Bucciarelli, S., Mehta, V., Sellés-Baiget, S., Solbak, S. M. Ø., Bach, A., Mesa, P., Hernandez, P. A., Montoya, G., Nguyen, T. T. T. N., Rand, K. D., Boesen, T. & Gajhede, M., 1 Dec 2019, In: Scientific Reports. 9, 13 p., 4019.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

57 Downloads (Pure)

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

Lundby, A., Franciosa, G., Emdal, K. B., Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, M., Montoya, G., Jensen, L. J. & Olsen, J. V., 3 Oct 2019, In: Cell. 179, 2, p. 543-560

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Structure of Csx1-cOA₄ complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

Molina, R., Stella, S., Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, G., 1 Dec 2019, In: Nature Communications. 10, 14 p., 4302.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

20 Downloads (Pure)

2018

A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

Han, W., Stella, S., Zhang, Y., Guo, T., Sulek, K., Peng-Lundgren, L., Montoya, G. & She, Q., 2018, In: Nucleic Acids Research. 46, 19, p. 10319-10330 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

69 Downloads (Pure)

Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

Stella, S., Mesa, P., Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, N. S. & Montoya, G., 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

46 Citations (Scopus)

How do CRISPR-Cas RNA-guided endonucleases cut specific DNA regions for Genome Editing?

Montoya, G., 2018, In: Acta Crystallographica Section A: Foundations and Advances. 74, p. E3 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

14 Downloads (Pure)

Molecular basis of Tousled-Like Kinase 2 activation

Mortuza, G. B., Hermida, D., Pedersen, A-K., Segura-Bayona, S., López-Méndez, B., Redondo, P., Rüther, P., Pozdnyakova, I., Garrote, A. M., Muñoz, I. G., Villamor-Payà, M., Jauset, C., Olsen, J. V., Stracker, T. H. & Montoya, G., 2018, In: Nature Communications. 9, 1, p. 2535 2535.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

77 Downloads (Pure)

Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

Prieto, J., Redondo, P., López-Méndez, B., D'Abramo, M., Merino, N., Blanco, F. J., Duchateau, P., Montoya, G. & Molina, R., 2018, In: Scientific Reports. 8, p. 1-9 10286.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

48 Downloads (Pure)

2017

Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail

Han, W., Pan, S., López-Méndez, B., Montoya, G. & She, Q., 1 Oct 2017, In: Nucleic Acids Research. 45, 18, p. 10740-10750 11 p., gkx726.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

330 Downloads (Pure)

A novel TPR-BEN domain interaction mediates PICH-BEND3 association

Pitchai, G. P., Kaulich, M., Bizard, A. H., Mesa, P., Yao, Q., Sarlos, K., Streicher, W. W., Nigg, E. A., Montoya, G. & Hickson, I. D., 2 Nov 2017, In: Nucleic Acids Research. 19, 2, p. 11413–11424

Research output: Contribution to journal › Journal article › Research › peer-review

208 Downloads (Pure)

Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA

Alcón, P., Montoya, G. & Stella, S., 1 Jul 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, Pt 7, p. 409-415 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

113 Downloads (Pure)

Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing

Stella, S., Alcón, P. & Montoya, G., 1 Nov 2017, In: Nature Structural and Molecular Biology. 24, 11, p. 882-892 11 p.

Research output: Contribution to journal › Review › peer-review

30 Citations (Scopus)

Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome

Alvarez-Cabrera, A. L., Delgado, S., Gil-Carton, D., Mortuza, G. B., Montoya, G., Sorzano, C. O. S., Tang, T. K. & Carazo, J. M., 27 Mar 2017, In: Frontiers in Molecular Biosciences. 4, 14 p., 17.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

65 Downloads (Pure)

Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

Alba, J., Marcaida, M. J., Prieto, J., Montoya, G., Molina, R. & D'Abramo, M., 1 Dec 2017, In: Journal of Computer - Aided Molecular Design. 31, 12, p. 1063-1072 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

Stella, S., Alcón, P. & Montoya, G., 22 Jun 2017, In: Nature. 546, 7659, p. 559-563 5 p.

Research output: Contribution to journal › Letter › peer-review

69 Citations (Scopus)

2016

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

Hertz, E. P. T., Kruse, T., Davey, N. E., López-Méndez, B., Sigurdsson, J. O., Montoya, G., Olsen, J. V. & Nilsson, J., 18 Aug 2016, In: Molecular Cell. 63, 4, p. 686-695 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

102 Citations (Scopus)

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

Starnes, L. M., Su, D., Pikkupeura, L. M., Weinert, B. T., Santos, M. A., Mund, A., Soria, R., Cho, Y-W., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J-E., Peng, W., Yuan, J., Ge, K., Montoya, G., Nussenzweig, A., Choudhary, C. R., & 1 othersDaniel, J. A., 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

72 Downloads (Pure)

Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

Pitchai, G. P., Hickson, I. D., Streicher, W., Montoya, G. & Mesa, P., Aug 2016, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 72, 8, p. 646-651 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics

Molina, R., Besker, N., Marcaida, M. J., Montoya, G., Prieto, J. & D'Abramo, M., 20 May 2016, In: ACS chemical biology. 11, 5, p. 1401–1407

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA

Boskovic, J., Bragado-Nilsson, E., Saligram Prabhakar, B., Yefimenko, I., Martínez-Gago, J., Muñoz, S., Méndez, J. & Montoya, G., 16 Sept 2016, In: Cell Cycle. 15, 18, p. 2431-40 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions

Prieto, J., Redondo, P., Merino, N., Villate, M., Montoya, G., Blanco, F. J. & Molina, R., Jun 2016, In: Acta crystallographica. Section F, Structural biology communications. 72, Pt 6, p. 473-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

The genome editing revolution: A CRISPR-Cas TALE off-target story

Stella, S. & Montoya, G., 1 Jul 2016, In: BioEssays. 38, S1, p. S4-S13

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

Hoffmann, S., Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, M., Montoya, G., Groth, A., Bekker-Jensen, S. & Mailand, N., 1 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

591 Downloads (Pure)

2015

Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification

Molina, R., Redondo, P., López-Méndez, B., Villate, M., Merino, N., Blanco, F. J., Valton, J., Grizot, S., Duchateau, P., Prieto, J. & Montoya, G., 27 Nov 2015, In: The Journal of Biological Chemistry. 290, 48, p. 28727-36 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Molina, R., Marcaida, M. J., Redondo, P., Marenchino, M., Duchateau, P., D'Abramo, M., Montoya, G. & Prieto, J., 24 Jul 2015, In: The Journal of Biological Chemistry. 290, 30, p. 18534-18544 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Functional and in silico assessment of MAX variants of unknown significance

Comino-Méndez, I., Leandro-García, L. J., Montoya, G., Inglada-Pérez, L., de Cubas, A. A., Currás-Freixes, M., Tysoe, C., Izatt, L., Letón, R., Gómez-Graña, Á., Mancikova, V., Apellániz-Ruiz, M., Mannelli, M., Schiavi, F., Favier, J., Gimenez-Roqueplo, A-P., Timmers, H. J. L. M., Roncador, G., Garcia, J. F., Rodríguez-Antona, C., & 2 othersRobledo, M. & Cascón, A., 1 Nov 2015, In: Journal of Molecular Medicine. 93, 11, p. 1247-55 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Structure of p15^PAF-PCNA complex and implications for clamp sliding during DNA replication and repair

De Biasio, A., de Opakua, A. I., Mortuza, G. B., Molina, R., Cordeiro, T. N., Castillo, F., Villate, M., Merino, N., Delgado, S., Gil-Cartón, D., Luque, I., Diercks, T., Bernadó, P., Montoya, G. & Blanco, F. J., 12 Mar 2015, In: Nature Communications. 6, p. 1-12 6439.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Visualizing phosphodiester-bond hydrolysis by an endonuclease

Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M. J., Orozco, M., Prieto, J. & Montoya, G., Jan 2015, In: Nature Structural and Molecular Biology. 22, 1, p. 65-72 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2014

BuD, a helix-loop-helix DNA-binding domain for genome modification

Stella, S., Molina, R., López-Méndez, B., Juillerat, A., Bertonati, C., Daboussi, F., Campos-Olivas, R., Duchateau, P. & Montoya, G., 1 Jan 2014, In: Acta Crystallographica Section D: Biological Crystallography. 70, 7, p. 2042-2052 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Comprehensive analysis of the specificity of transcription activator-like effector nucleases

Juillerat, A., Dubois, G., Valton, J., Thomas, S., Stella, S., Maréchal, A., Langevin, S., Benomari, N., Bertonati, C., Silva, G. H., Daboussi, F., Epinat, J-C., Montoya, G., Duclert, A. & Duchateau, P., Apr 2014, In: Nucleic Acids Research. 42, 8, p. 5390-402 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA

Redondo, P., Merino, N., Villate, M., Blanco, F. J., Montoya, G. & Molina, R., Feb 2014, In: Acta crystallographica. Section F, Structural biology communications. 70, Pt 2, p. 256-9 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA

Stella, S., Molina, R., Bertonatti, C., Juillerrat, A. & Montoya, G., 1 Jan 2014, In: Acta Crystallographica Section F:Structural Biology Communications. 70, 1, p. 87-91 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation

Mortuza, G. B., Cavazza, T., Garcia-Mayoral, M. F., Hermida, D., Peset, I., Pedrero, J. G., Merino, N., Blanco, F. J., Lyngsø, J., Bruix, M., Pedersen, J. S., Vernos, I. & Montoya, G., 29 Sept 2014, In: Nature Communications. 5, p. 1-12 12 p., 5072.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2013

Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism

Stella, S., Molina, R., Yefimenko, I., Prieto, J., Silva, G., Bertonati, C., Juillerat, A., Duchateau, P. & Montoya, G., 1 Sept 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 9, p. 1707-1716 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2012

5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases

Valton, J., Daboussi, F., Leduc, S., Molina, R., Redondo, P., Macmaster, R., Montoya, G. & Duchateau, P., 31 Aug 2012, In: The Journal of Biological Chemistry. 287, 36, p. 30139-50 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Molecular scissors for in situ cellular repair

Prieto, J., Molina, R. & Montoya, G., May 2012, In: Critical Reviews in Biochemistry and Molecular Biology. 47, 3, p. 207-21 15 p.

Research output: Contribution to journal › Review › peer-review

13 Citations (Scopus)

Non-specific protein-DNA interactions control I-CreI target binding and cleavage

Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F. L., Charles Epinat, J., Valton, J., Grizot, S., Duchateau, P., Prieto, J. & Montoya, G., 1 Aug 2012, In: Nucleic Acids Research. 40, 14, p. 6936-6945 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Guillermo Montoya

Research output

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