Research output per year
Research output per year
Personal profile
CV
Scientific Career
- 2017 Professor MSO, Dept. of Pharmacy, University of Copenhagen
- 2012 Group Leader, Protein Analysis Lab, Dept. of Pharmacy, University of Copenhagen
- 2011 Associate Professor, Dept. of Pharmacy, University of Copenhagen
- 2010 Post-doctoral Fellow at the Swiss Institute of Bioinformatics, Lausanne, Switzerland
- 2009 Post-doctoral Fellow at Northeastern University, Boston, USA
- 2008 Post-doctoral Fellow at University of Southern Denmark, Odense
- 2004 Industrial Ph.D student, Novo Nordisk A/S / University of Southern Denmark, Odense
- 2004 Research scientist, Novo Nordisk A/S
- 2003 Research assistant, Dept. of Protein Chemistry, University of Copenhagen
- 2003 Master thesis student, Dept. of Protein Chemistry, University of Copenhagen
Academic Education
- 2007 Ph.D in Biochemistry, Protein Research Group, University of Southern Denmark
- 2003 MSc in Biochemistry, Department of Protein Chemistry, University of Copenhagen
Awards and Fellowships
- 2016-2020 Sapere Aude Research Leader (DFF-Forskningsleder) of the Danish Research Councils
- 2016-2020 Industrial Doctorate Programme recipient (EID) from EU (main academic partner)
- 2011-2015 Steno Fellowship from the Danish Research Council
- 2011-2015 Marie Curie Career Integration Award
- 2010-2013 Post-doctoral fellowship from the Human Frontier Science Programme (HFSP)
- 2010-2013 Post-doctoral fellowship (IIF) from the Marie Curie Actions programme (declined)
- 2010-2011 Post-doctoral fellowship from the Carlsberg Foundation (declined)
- 2008-2010 Post-doctoral fellowship from the Danish Research Council
- 2004-2007 Industrial PhD fellowship from the Danish Research Council
- 2002-2003 MSc fellowrship from the Danish Biotechnology Priority Area
Research grants and funding
- 2004-2016 Total personal share (approx. 3.2 mill EUR.)
- 2016 The Danish Research Councils (Sapere Aude grant)
- 2016 Horizon2020 (EID grant)
- 2014 InnovationFonden and Lundbeck A/S
- 2013 University of Copenhagen (KU2016)
- 2012 The Danish Independent Research Council
- 2012 Roche Healthcare
- 2012 Novo Nordisk STAR programme
- 2011 The Danish Independent Research Council
- 2011 EU (7th Framework programme)
- 2011 Waters Corporation (Instrument Donation)
- 2010 Human Frontier Science Programme
- 2010 Carlsberg Foundation
- 2010 EU (7th Framework programme)
- 2008 The Danish Independent Research Council
Research Supervision
- Main supervisor of PhD students: Patrick Merkle, Ingvar Møller, Zeinab Nasari, Esben Trabjerg, Ulrik Mistarz
- Main supervisor of >15 Master thesis students
- Supervisor of Postdocs: Pernille Foged Jensen and Signe Seger
- Supervisor of Assistant Professor: Tam T.T Nguyen
Scientific Mediation
- Invited Speaker at the 2nd International Conference on HDX-MS (Canada) 2019
- Invited Speaker at the Annual Meeting of the Norwegian MS Society (Norway) 2018
- Invited Speaker at the 8th Symposium on Structural Proteomics (Germany) 2017
- Invited Speaker at the 7th Symposium on Structural Proteomics (Austria) 2017
- Invited Speaker at the 1st International Conference on HDX-MS (Sweden)
- 2016 Speaker at the 21st International Mass Spectrometry Society Conference, Toronto, Canada.
- 2015 Speaker at the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, USA.
- 2014 Session chair at the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, USA.
- 2014 Speaker at the 21st Scientific Symposium on Mass Spectrometry, Manchester, UK
- 2012 Speaker at 19th International Mass Spectrometry Conference, Kyoto, Japan
- 2012 Invited speaker at 2nd conference on Analytical Technologies for Biotherapeutic Development, San Diego, USA
- 2011 Invited speaker at the 2nd Waters Proteomics Summit Meeting, Manchester, UK.
- 2011 Invited speaker at the Waters Nordic MS Meeting, Bådstad, Sweden.
- 2010 Speaker at the 58th ASMS Conference on Mass Spectrometry and Allied Topics, USA.
- 2008 Speaker at the 5th Uppsala Conference on Electron Capture and Transfer Dissociation. Paris, France.
- 2007 Speaker at the XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.
- 2007 - >50 guest lectures at universities and pharmaceutical companies in Europe and USA.
- 2007 - Journal reviewer for Anal. Chem., Mol.Cell.Proteom., J.Am.Chem.Soc., Protein Sci., Phys.Chem. Chem. Phys, Pharm. Res., J. Pharm. Sci., J. Am. Soc. Mass Spectrom., Analyst, Pharm. Res. Amino Acids.
Pedagogical Education
- 2014 Course on supervision of PhD students, University of Copenhagen
- 2012 University Teaching Certificate (Adjunktpædagogikum gennemført ved Institut for Naturfagenes Didaktik, University of Copenhagen)
- 2007 Introductory course to University Teaching (Introduktion til Universitetspædagogik, IUP).
Main Teaching
- Course SFABA0262U Analytical Chemistry, Instrumental, Laboratory Course
- Course SFKKIF002U, Biopharmaceuticals: Protein Production and Analysis - course responsible.
- Course FFKKA9021, Principles and Practice of Bioanalysis.
- Course 3132-16-00-00: Mass Spectrometry Coupled to Separation Techniques in Bioanalytical Chemistry.
- Course 3136150000: Analytical Methodology in Protein Formulation Development.
Short presentation
Position
- Group Leader, Protein Analysis Lab, Dept. of Pharmacy, University of Copenhagen
Research Interests
- Bioanalytical Chemistry & Protein Analytical Chemistry
- Analysis of the primary structure of proteins by liquid chromatography and mass spectrometry
- Analysis of the higher-order structure and molecular interactions of proteins of pharmaceutical interest by hydrogen/deuterium exchange mass spectrometry (HDX-MS)
- Quantitative analysis of proteins by mass spectrometry-based methods
Research Supervision
- Main supervisor of PhD students: Patrick Merkle, Ingvar Møller, Zeinab Nasari, Esben Trabjerg, Ulrik Mistarz
- Main supervisor of >10 Master thesis students
- Supervisor of Postdocs: Pernille Foged Jensen and Signe Seger
- Supervisor of Assistant Professor: Tam T.T Nguyen
Main Teaching
- Course SFABA0262U Analytical Chemistry, Instrumental, Laboratory Course
- Course SFKKIF002U, Biopharmaceuticals: Protein Production and Analysis - course responsible.
- Course FFKKA9021, Principles and Practice of Bioanalysis.
- Course 3132-16-00-00: Mass Spectrometry Coupled to Separation Techniques in Bioanalytical Chemistry.
- Course 3136150000: Analytical Methodology in Protein Formulation Development.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Former Faculty of Pharmaceutical Sciences
- Protein characterisation
- Protein structure
- Analytical Chemistry
- Mass Spectrometry
- Protein Structure Prediction
- Biopharmaceuticals
- Protein
- Faculty of Health and Medical Sciences
Fingerprint
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Research output
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Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines
Castelli, R., Scalvini, L., Vacondio, F., Lodola, A., Anselmi, M., Vezzosi, S., Carmi, C., Bassi, M., Ferlenghi, F., Rivara, S., Möller, I. R., Rand, K. D., Daglian, J., Wei, D., Dotsey, E. Y., Ahmed, F., Jung, K.-M., Stella, N., Singh, S. & Mor, M. & 1 others, , 13 Feb 2020, In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
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A post-translational modification of human Norovirus capsid protein attenuates glycan binding
Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, E., Stehle, T., Rand, K. D., Blaum, B. S., Uetrecht, C. & Peters, T., 1 Dec 2019, In: Nature Communications. 10, 1, 14 p., 1320.Research output: Contribution to journal › Journal article › Research › peer-review
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Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution
Johansen, N. T., Tidemand, F. G., Nguyen, T. T. T. N., Rand, K. D., Pedersen, M. C. & Arleth, L., May 2019, In: F E B S Journal. 286, 9, p. 1734-1751Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational dynamics of the human serotonin transporter during substrate and drug binding
Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, S. G. F., Gether, U., Loland, C. J. & Rand, K. D., 1 Dec 2019, In: Nature Communications. 10, 1, 1687.Research output: Contribution to journal › Journal article › Research › peer-review
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Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 degrees C and 25.4 degrees C for the Fab Fragment of NISTmAb
Hudgens, J. W., Gallagher, E. S., Karageorgos, I., Anderson, K. W., Huang, R.Y.-C., Chen, G., Bou-Assaf, G. M., Espada, A., Chalmers, M. J., Harguindey, E., Zhang, H.-M., Walters, B. T., Zhang, J., Venable, J., Steckler, C., Park, I., Brock, A., Lu, X., Pandey, R. & Chandramohan, A. & 16 others, , 2 May 2019, In: Journal of Research of the National Institute of Standards and Technology. 124, 7 p., 124009.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments
Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Merkle, P. S., Liskova, R., Polak, M., Loland, C. J., Kadek, A., Man, P. & Rand, K. D., 3 Sept 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb
Hudgens, J. W., Gallagher, E. S., Karageorgos, I., Anderson, K. W., Filliben, J. J., Huang, R.Y.-C., Chen, G., Bou-Assaf, G. M., Espada, A., Chalmers, M. J., Harguindey, E., Zhang, H.-M., Walters, B. T., Zhang, J., Venable, J. D., Steckler, C., Park, I., Brock, A., Lu, X. & Pandey, R. K. & 17 others, , 4 Jun 2019, In: Analytical Chemistry. 91, 11, p. 7336-7345Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Trabjerg, E., Abu-Asad, N., Wan, Z., Kartberg, F., Christensen, S. & Rand, K. D., 2 Jul 2019, In: Structure. 27, 7, p. 1103-1113.e3Research output: Contribution to journal › Journal article › Research › peer-review