Brice Emanuelli

Research output

Research output per year 2000 2001 2008 2011 2012 2018 2019 2019

• 21 Journal article
• 2 Comment/debate
• 1 Book chapter
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue

  Lundh, M., Petersen, P. S., Isidor, M. S., Kazoka-Sørensen, D. N., Plucińska, K., Shamsi, F., Ørskov, C., Tozzi, M., Brown, E. L., Andersen, E., Ma, T., Müller, U. A., Barrès, R., Kristiansen, V. B., Gerhart-Hines, Z., Tseng, Y-H. & Emanuelli, B., 2019, In: EMBO Reports. 20, 8, e48216.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • afadin 100%
  • Insulin Derivative 57%
  • Adipose Tissue 47%
  • Insulin 38%
  • Protein 23%
  5 Citations (Scopus)

• Identification of two microRNA nodes as potential cooperative modulators of liver metabolism

  Hochreuter, M. Y., Altıntaş, A., Garde, C., Emanuelli, B., Kahn, C. R., Zierath, J. R., Vienberg, S. & Barrès, R., 1 Dec 2019, In: Hepatology Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNAs 100%
  • Liver 61%
  • Insulin Resistance 27%
  • Energy Metabolism 23%
  • Insulin Receptor 19%
  4 Citations (Scopus)

• The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression

  Wen, Q., Xie, X., Zhao, C., Ren, Q., Zhang, X., Wei, D., Emanuelli, B. & Du, Y., 20 Jun 2019, In: The Science of the Total Environment. 670, p. 67-77 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peroxisome Proliferator-Activated Receptors 100%
  • Carrier Proteins 78%
  • Flame retardants 58%
  • PBDE 57%
  • flame retardant 56%
  7 Citations (Scopus)
• 2018

  Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

  Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S., & 24 othersWang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjær, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y-H., Færgeman, N. J. & Gerhart-Hines, Z., 3 Jul 2018, In: Cell Metabolism. 28, 1, p. 159-174.e11

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Beige Adipose Tissue 100%
  • Cardiolipins 71%
  • Brown Adipose Tissue 70%
  • Energy Metabolism 52%
  • Phospholipids 52%
  43 Citations (Scopus)

  187 Downloads (Pure)

• Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

  Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Ronald Kahn, C. & Emanuelli, B., Jul 2018, In: Cellular Signalling. 47, p. 1-15

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin Receptor Substrate Proteins 100%
  • Insulin-Like Growth Factor I 77%
  • Insulin 52%
  • Phosphorylation 19%
  • NIMA-Interacting Peptidylprolyl Isomerase 13%
  19 Citations (Scopus)
• 2017

  Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

  Lundh, M., Pluciñska, K., Isidor, M. S., Petersen, P. S. S. & Emanuelli, B., Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adipocytes 100%
  • Small Interfering RNA 87%
  • Gene Expression 62%
  • Gene Editing 25%
  • Adipogenesis 25%
  20 Citations (Scopus)

  90 Downloads (Pure)
• 2016

  Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5)

  Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 5 Aug 2016, In: The Journal of Biological Chemistry. 291, 32, p. 16878

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  3 Citations (Scopus)
• 2015

  Interplay between FGF21 and insulin action in the liver regulates metabolism

  Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., Jan 2015, In: The Journal of Clinical Investigation. 125, 1, p. 458

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  9 Citations (Scopus)
• 2014

  Interplay between FGF21 and insulin action in the liver regulates metabolism

  Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., 3 Feb 2014, In: The Journal of Clinical Investigation. 124, 2, p. 515-27 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • fibroblast growth factor 21 100%
  • Insulin 46%
  • Liver 35%
  • Brown Adipose Tissue 27%
  • White Adipose Tissue 18%
  151 Citations (Scopus)
• 2012

  Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

  Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., Emanuelli, B., Smyth, G., Cinti, S., Newgard, C. B., Gibson, B. W., Larsson, N-G. & Kahn, C. R., 5 Dec 2012, In: Cell Metabolism. 16, 6, p. 765-76 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adipose Tissue 100%
  • Insulin Resistance 98%
  • Obesity 83%
  • Mitochondria 49%
  • mitochondrial transcription factor A 31%
  130 Citations (Scopus)

• Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5)

  Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12016-26 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Low Density Lipoprotein Receptor-Related Protein-5 100%
  • Wnt Receptors 91%
  • Low-Density Lipoprotein 69%
  • Insulin Derivative 60%
  • Insulin 40%
  62 Citations (Scopus)

• Intrinsic differences in adipocyte precursor cells from different white fat depots

  Macotela, Y., Emanuelli, B., Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y-H. & Kahn, C. R., Jul 2012, In: Diabetes. 61, 7, p. 1691-9 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • White Adipocytes 100%
  • Adipocytes 63%
  • Obesity 31%
  • 129 Strain Mouse 16%
  • Bone Morphogenetic Protein 4 16%
  189 Citations (Scopus)
• 2011

  Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

  Macotela, Y., Emanuelli, B., Bång, A. M., Espinoza, D. O., Boucher, J., Beebe, K., Gall, W. & Kahn, C. R., 2011, In: PLOS ONE. 6, 6, p. e21187

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin 100%
  • Metabolism 94%
  • insulin resistance 86%
  • Resistance 74%
  • Leucine 72%
  173 Citations (Scopus)

• Insulin resistance in the metabolic syndrome

  Biddinger, S. B. & Emanuelli, B., 1 Dec 2011, Metabolic Basis of Obesity. Springer New York LLC, p. 175-198 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  • Metabolic Syndrome 100%
  • Insulin Resistance 89%
  • Hypertriglyceridemia 82%
  • Cardiovascular Diseases 78%
  • HDL Cholesterol 65%
  4 Citations (Scopus)

• PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

  Bezy, O., Tran, T. T., Pihlajamäki, J., Suzuki, R., Emanuelli, B., Winnay, J., Mori, M. A., Haas, J., Biddinger, S. B., Leitges, M., Goldfine, A. B., Patti, M. E., King, G. L. & Kahn, C. R., 1 Jun 2011, In: The Journal of Clinical Investigation. 121, 6, p. 2504-17 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin Resistance 100%
  • 129 Strain Mouse 78%
  • Liver 62%
  • Insulin 35%
  • Chromosomes, Human, Pair 14 23%
  86 Citations (Scopus)

• Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

  Jing, E., Emanuelli, B., Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M. & Kahn, C. R., 30 Aug 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14608-13 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sirtuin 3 100%
  • Reactive Oxygen Species 50%
  • Skeletal Muscle 49%
  • Insulin 42%
  • Sirtuins 17%
  305 Citations (Scopus)
• 2010

  Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis

  Zhang, H., Schulz, T. J., Espinoza, D. O., Huang, T. L., Emanuelli, B., Kristiansen, K. & Tseng, Y-H., 1 Sept 2010, In: Molecular and Cellular Biology. 30, 17, p. 4224-33 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bone Morphogenetic Proteins 100%
  • Adipogenesis 99%
  • Insulin 56%
  • Insulin Receptor Substrate Proteins 53%
  • Null Lymphocytes 26%
  50 Citations (Scopus)
• 2008

  Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

  Emanuelli, B., Eberlé, D., Suzuki, R. & Kahn, C. R., 4 Mar 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3545-50 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dual-Specificity Phosphatases 100%
  • Phosphoric Monoester Hydrolases 66%
  • Insulin Resistance 53%
  • Phosphotransferases 50%
  • Phosphorylation 38%
  73 Citations (Scopus)

• SOCS-1 deficiency does not prevent diet-induced insulin resistance

  Emanuelli, B., Macotela, Y., Boucher, J. & Ronald Kahn, C., 12 Dec 2008, In: Biochemical and Biophysical Research Communications. 377, 2, p. 447-52 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin Derivative 100%
  • Insulin Resistance 80%
  • Diet 67%
  • Resistance 61%
  • Cytokines 60%
  16 Citations (Scopus)
• 2006

  Critical nodes in signalling pathways: insights into insulin action

  Taniguchi, C. M., Emanuelli, B. & Kahn, C. R., Feb 2006, In: Nature Reviews. Molecular Cell Biology. 7, 2, p. 85-96 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Signal Transduction 100%
  • Insulin 87%
  1859 Citations (Scopus)
• 2004

  The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

  Emanuelli, B., Glondu, M., Filloux, C., Peraldi, P. & Van Obberghen, E., Dec 2004, In: Diabetes. 53 Suppl 3, p. S97-S103

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin-Secreting Cells 100%
  • Interleukin-1beta 88%
  • Insulin Receptor 65%
  • Insulin 63%
  • Cytokines 57%
  38 Citations (Scopus)
• 2001

  Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase

  Peraldi, P., Filloux, C., Emanuelli, B., Hilton, D. J. & Van Obberghen, E., 6 Jul 2001, In: Journal of Biological Chemistry. 276, 27, p. 24614-24620 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 3-tyrosine 100%
  • Janus Kinases 81%
  • Insulin Derivative 63%
  • Tyrosine 56%
  • Phosphorylation 42%
  50 Citations (Scopus)

• SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

  Emanuelli, B., Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D. J., Hotamisligil, G. S. & Van Obberghen, E., 21 Dec 2001, In: Journal of Biological Chemistry. 276, 51, p. 47944-47949 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Obese Mice 100%
  • Insulin Derivative 83%
  • Adipose Tissue 68%
  • Tumor Necrosis Factor-alpha 58%
  • Insulin 55%
  356 Citations (Scopus)

• Surfing the insulin signaling web

  Van Obberghen, E., Baron, V., Delahaye, L., Emanuelli, B., Filippa, N., Giorgetti-Peraldi, S., Lebrun, P., Mothe-Satney, I., Peraldi, P., Rocchi, S., Sawka-Verhelle, D., Tartare-Deckert, S. & Giudicelli, J., 1 Dec 2001, In: European Journal of Clinical Investigation. 31, 11, p. 966-977 12 p.

  Research output: Contribution to journal › Review › peer-review

  • SH2 Domain-Containing Protein Tyrosine Phosphatases 100%
  • Insulin Receptor Substrate Proteins 80%
  • Phosphotyrosine 79%
  • Protein Tyrosine Phosphatases 76%
  • src Homology Domains 75%
  71 Citations (Scopus)
• 2000

  SOCS-3 is an insulin-induced negative regulator of insulin signaling

  Emanuelli, B., Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D. & Van Obberghen, E., 26 May 2000, In: Journal of Biological Chemistry. 275, 21, p. 15985-15991 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin Derivative 100%
  • Insulin 66%
  • Insulin Receptor 61%
  • Tyrosine 20%
  • Suppressor of Cytokine Signaling Proteins 17%
  365 Citations (Scopus)