Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G Sustarsic; Tao Ma; Matthew D Lynes; Michael Larsen; Iuliia Karavaeva; Jesper F Havelund; Carsten H Nielsen; Mark P Jedrychowski; Marta Moreno-Torres; Morten Lundh; Kaja Plucinska; Naja Z Jespersen; Trisha J Grevengoed; Barbara Kramar; Julia Peics; Jakob B Hansen; Farnaz Shamsi; Isabel Forss; Ditte Neess; Susanne Keipert; Jianing Wang; Katharina Stohlmann; Ivan Brandslund; Cramer Christensen; Marit E Jørgensen; Allan Linneberg; Oluf Pedersen; Michael A Kiebish; Klaus Qvortrup; Xianlin Han; Bente Klarlund Pedersen; Martin Jastroch; Susanne Mandrup; Andreas Kjær; Steven P Gygi; Torben Hansen; Matthew P Gillum; Niels Grarup; Brice Emanuelli; Søren Nielsen; Camilla Scheele; Yu-Hua Tseng; Nils J Færgeman; Zachary Gerhart-Hines

doi:10.1016/j.cmet.2018.05.003

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G Sustarsic, Tao Ma, Matthew D Lynes, Michael Larsen, Iuliia Karavaeva, Jesper F Havelund, Carsten H Nielsen, Mark P Jedrychowski, Marta Moreno-Torres, Morten Lundh, Kaja Plucinska, Naja Z Jespersen, Trisha J Grevengoed, Barbara Kramar, Julia Peics, Jakob B Hansen, Farnaz Shamsi, Isabel Forss, Ditte Neess, Susanne KeipertJianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P Gygi, Torben Hansen, Matthew P Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu-Hua Tseng, Nils J Færgeman, Zachary Gerhart-Hines

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Abstract

Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

Original language	English
Journal	Cell Metabolism
Volume	28
Issue number	1
Pages (from-to)	159-174.e11
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2018.05.003
Publication status	Published - 3 Jul 2018

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Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., ... Gerhart-Hines, Z. (2018). Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism, 28(1), 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

Sustarsic, EG, Ma, T, Lynes, MD, Larsen, M , Karavaeva, I, Havelund, JF, Nielsen, CH, Jedrychowski, MP, Moreno-Torres, M, Lundh, M, Plucinska, K, Jespersen, NZ, Grevengoed, TJ, Kramar, B, Peics, J, Hansen, JB, Shamsi, F, Forss, I, Neess, D, Keipert, S, Wang, J, Stohlmann, K, Brandslund, I, Christensen, C, Jørgensen, ME, Linneberg, A , Pedersen, O, Kiebish, MA, Qvortrup, K, Han, X, Pedersen, BK, Jastroch, M, Mandrup, S, Kjær, A, Gygi, SP, Hansen, T , Gillum, MP , Grarup, N , Emanuelli, B, Nielsen, S, Scheele, C, Tseng, Y-H, Færgeman, NJ & Gerhart-Hines, Z 2018, 'Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis', Cell Metabolism, vol. 28, no. 1, pp. 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

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title = "Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis",

abstract = "Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.",

author = "Sustarsic, {Elahu G} and Tao Ma and Lynes, {Matthew D} and Michael Larsen and Iuliia Karavaeva and Havelund, {Jesper F} and Nielsen, {Carsten H} and Jedrychowski, {Mark P} and Marta Moreno-Torres and Morten Lundh and Kaja Plucinska and Jespersen, {Naja Z} and Grevengoed, {Trisha J} and Barbara Kramar and Julia Peics and Hansen, {Jakob B} and Farnaz Shamsi and Isabel Forss and Ditte Neess and Susanne Keipert and Jianing Wang and Katharina Stohlmann and Ivan Brandslund and Cramer Christensen and J{\o}rgensen, {Marit E} and Allan Linneberg and Oluf Pedersen and Kiebish, {Michael A} and Klaus Qvortrup and Xianlin Han and Pedersen, {Bente Klarlund} and Martin Jastroch and Susanne Mandrup and Andreas Kj{\ae}r and Gygi, {Steven P} and Torben Hansen and Gillum, {Matthew P} and Niels Grarup and Brice Emanuelli and S{\o}ren Nielsen and Camilla Scheele and Yu-Hua Tseng and F{\ae}rgeman, {Nils J} and Zachary Gerhart-Hines",

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AU - Sustarsic, Elahu G

AU - Ma, Tao

AU - Lynes, Matthew D

AU - Larsen, Michael

AU - Karavaeva, Iuliia

AU - Havelund, Jesper F

AU - Nielsen, Carsten H

AU - Jedrychowski, Mark P

AU - Moreno-Torres, Marta

AU - Lundh, Morten

AU - Plucinska, Kaja

AU - Jespersen, Naja Z

AU - Grevengoed, Trisha J

AU - Kramar, Barbara

AU - Peics, Julia

AU - Hansen, Jakob B

AU - Shamsi, Farnaz

AU - Forss, Isabel

AU - Neess, Ditte

AU - Keipert, Susanne

AU - Wang, Jianing

AU - Stohlmann, Katharina

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Jørgensen, Marit E

AU - Linneberg, Allan

AU - Pedersen, Oluf

AU - Kiebish, Michael A

AU - Qvortrup, Klaus

AU - Han, Xianlin

AU - Pedersen, Bente Klarlund

AU - Jastroch, Martin

AU - Mandrup, Susanne

AU - Kjær, Andreas

AU - Gygi, Steven P

AU - Hansen, Torben

AU - Gillum, Matthew P

AU - Grarup, Niels

AU - Emanuelli, Brice

AU - Nielsen, Søren

AU - Scheele, Camilla

AU - Tseng, Yu-Hua

AU - Færgeman, Nils J

AU - Gerhart-Hines, Zachary

PY - 2018/7/3

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AB - Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

U2 - 10.1016/j.cmet.2018.05.003

DO - 10.1016/j.cmet.2018.05.003

M3 - Journal article

C2 - 29861389

SN - 1550-4131

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SP - 159-174.e11

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Abstract

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