Critical nodes in signalling pathways: insights into insulin action

Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn

doi:10.1038/nrm1837

Critical nodes in signalling pathways: insights into insulin action

Cullen M Taniguchi, Brice Emanuelli, C Ronald Kahn

1859 Citations (Scopus)

Abstract

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

Original language	English
Journal	Nature Reviews. Molecular Cell Biology
Volume	7
Issue number	2
Pages (from-to)	85-96
Number of pages	12
ISSN	1471-0072
DOIs	https://doi.org/10.1038/nrm1837
Publication status	Published - Feb 2006

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title = "Critical nodes in signalling pathways: insights into insulin action",

abstract = "Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.",

keywords = "Animals, Humans, Insulin, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Receptor, Insulin, Signal Transduction",

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AU - Emanuelli, Brice

AU - Kahn, C Ronald

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AB - Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

KW - Animals

KW - Humans

KW - Insulin

KW - Phosphatidylinositol 3-Kinases

KW - Proto-Oncogene Proteins c-akt

KW - Receptor, Insulin

KW - Signal Transduction

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DO - 10.1038/nrm1837

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JF - Nature Reviews Molecular Cell Biology

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Critical nodes in signalling pathways: insights into insulin action

Abstract

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