Research output per year
Research output per year
Personal profile
Short presentation
The prevalence of obesity and type 2 diabetes is rising at alarming rates worldwide, and urges for the discovery of new therapeutic options. These metabolic disorders are characterized by insulin resistance, i.e. an inappropriate response to insulin in its target tissues, including muscle, adipose tissues and liver.
The main research area of my group is the investigation of the molecular mechanisms involved in the transduction of insulin signalling and the regulation of metabolic processes.
In particular, we are interested in:
- Dissecting the signaling events mediating the various actions of insulin to control metabolic outcomes and cellular differentiation.
- Studying how the complex nature of the insulin signaling network is perturbed in conditions of insulin resistance.
Our molecular interrogation of the insulin signalling cascades aims to identify new avenues for the development of therapeutic strategies to treat insulin resistance with the long-term goal of preventing type 2 diabetes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Insulin
- Insulin resistance
- signal transduction
- obesity
- Metabolism
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Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue
Lundh, M., Petersen, P. S., Isidor, M. S., Kazoka-Sørensen, D. N., Plucińska, K., Shamsi, F., Ørskov, C., Tozzi, M., Brown, E. L., Andersen, E., Ma, T., Müller, U. A., Barrès, R., Kristiansen, V. B., Gerhart-Hines, Z., Tseng, Y-H. & Emanuelli, B., 2019, In: EMBO Reports. 20, 8, e48216.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter, M. Y., Altıntaş, A., Garde, C., Emanuelli, B., Kahn, C. R., Zierath, J. R., Vienberg, S. & Barrès, R., 1 Dec 2019, In: Hepatology Research.Research output: Contribution to journal › Journal article › Research › peer-review
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The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression
Wen, Q., Xie, X., Zhao, C., Ren, Q., Zhang, X., Wei, D., Emanuelli, B. & Du, Y., 20 Jun 2019, In: The Science of the Total Environment. 670, p. 67-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S., & 24 others, 3 Jul 2018, In: Cell Metabolism. 28, 1, p. 159-174.e11Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action
Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Ronald Kahn, C. & Emanuelli, B., Jul 2018, In: Cellular Signalling. 47, p. 1-15Research output: Contribution to journal › Journal article › Research › peer-review
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Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA
Lundh, M., Pluciñska, K., Isidor, M. S., Petersen, P. S. S. & Emanuelli, B., Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5)
Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 5 Aug 2016, In: The Journal of Biological Chemistry. 291, 32, p. 16878Research output: Contribution to journal › Comment/debate › Research › peer-review
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Interplay between FGF21 and insulin action in the liver regulates metabolism
Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., Jan 2015, In: The Journal of Clinical Investigation. 125, 1, p. 458Research output: Contribution to journal › Comment/debate › Research › peer-review