Birthe Brandt Kragelund

2019

Alginate Trisaccharide Binding Sites on the Surface of β-Lactoglobulin Identified by NMR Spectroscopy: Implications for Molecular Network Formation

Stender, E. G. P., Birch, J., Kjeldsen, C., Nielsen, L. D., Duus, J. Ø., Kragelund, B. B. & Svensson, B., 2019, In: ACS Omega. 4, 4, p. 6165-6174 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

26 Downloads (Pure)

Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., 17 Dec 2019, In: Biochemistry.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions

Cragnell, C., Staby, L., Lenton, S., Kragelund, B. B. & Skepö, M., May 2019, In: Biomolecules. 9, 5, 20 p., 168.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

10 Downloads (Pure)

Molecular basis for the binding and selective dephosphorylation of Na⁺/H⁺ exchanger 1 by calcineurin

Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, L. M., Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, B. B., Pedersen, S. F. & Peti, W., 1 Dec 2019, In: Nature Communications. 10, 13 p., 3489.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

17 Downloads (Pure)

R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

Millard, P. S., Kragelund, B. B. & Burow, M., Oct 2019, In: Trends in Plant Science. 24, 10, p. 934-946

Research output: Contribution to journal › Review › peer-review

19 Citations (Scopus)

Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

Hendus-Altenburger, R., Fernandes, C. B., Bugge, K., Kunze, M. B. A., Boomsma, W. & Kragelund, B. B., 1 Dec 2019, In: Journal of Biomolecular NMR. 73, 12, p. 713–725 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

3 Downloads (Pure)

Specificity of MYB interactions relies on motifs in ordered and disordered contexts

Millard, P. S., Weber, K., Kragelund, B. B. & Burow, M., 1 Mar 2019, In: Nucleic Acids Research. 47, 18, p. 9592-9608 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Downloads (Pure)

Temperature Dependence of Intrinsically Disordered Proteins in Simulations: What are We Missing?

Jephthah, S., Staby, L., Kragelund, B. B. & Skepö, M., 9 Apr 2019, In: Journal of Chemical Theory and Computation. 15, 4, p. 2672-2683

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

64 Downloads (Pure)

The PCNA interaction motifs revisited: thinking outside the PIP-box

Prestel, A., Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, O., Willemoës, M., Ploug, M., Boomsma, W. & Kragelund, B. B., 1 Dec 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

Sjøgaard, I. M. Z., Bressendorff, S., Prestel, A., Kausika, S., Oksbjerg, E., Kragelund, B. B. & Brodersen, P., 2019, In: Biochemical Journal. 476, 3, p. 449-465 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit

He, L., Cohen, E. B., Edwards, A. P. B., Xavier-Ferrucio, J., Bugge, K., Federman, R. S., Absher, D., Myers, R. M., Kragelund, B. B., Krause, D. S. & DiMaio, D., 26 Jul 2019, In: iScience. 17, p. 167-181 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

8 Downloads (Pure)

2018

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

Kristensen, K. K., Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, N., Beigneux, A. P., Kragelund, B. B., Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, M., 26 Jun 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. & Waters, M. J., 25 Jan 2018, In: Oncogene. 37, p. 489-501 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

90 Downloads (Pure)

Characterization of Dynamic IDP Complexes by NMR Spectroscopy

Prestel, A., Bugge, K., Staby, L., Hendus-Altenburger, R. & Kragelund, B. B., 2018, Intrinsically Disordered Proteins. Rhoades, E. (ed.). Academic Press, p. 193-226 34 p. (Methods in Enzymology, Vol. 611).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

9 Citations (Scopus)

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, B. B. & Hartmann-Petersen, R., 23 Oct 2018, In: Cell Reports. 25, 4, p. 862-870

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

52 Downloads (Pure)

Extreme disorder in an ultrahigh-affinity protein complex

Borgia, A., Borgia, M. B., Bugge, K. Ø., Kissling, V. M., Heidarsson, P. O., Fernandes, C. B., Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., Kragelund, B. B., Best, R. B. & Schuler, B., 1 Mar 2018, In: Nature. 555, p. 61-66 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

235 Citations (Scopus)

Role of protein dynamics in transmembrane receptor signalling

Wang, Y., Bugge, K. Ø., Kragelund, B. B. & Lindorff-Larsen, K., Feb 2018, In: Current Opinion in Structural Biology. 48, p. 74-82 9 p.

Research output: Contribution to journal › Review › peer-review

12 Citations (Scopus)

Structure of radical-induced cell death1 hub domain reveals a common αα-scaffold for disorder in transcriptional networks

Bugge, K. Ø., Staby, L., Kemplen, K. R., O'Shea, C., Bendsen, S. K., Jensen, M. K., Olsen, J. G., Skriver, K. & Kragelund, B. B., 1 May 2018, In: Structure. 26, 5, p. 734-746 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective

Choudhary, D., Kragelund, B. B., Heidarsson, P. O. & Cecconi, C., 17 Dec 2018, In: Frontiers in Molecular Neuroscience. 11, p. 1-8 468.

Research output: Contribution to journal › Review › peer-review

4 Citations (Scopus)

44 Downloads (Pure)

2017

(S)Pinning down protein interactions by NMR

Teilum, K., Kunze, M. B. A., Erlendsson, S. & Kragelund, B. B., 1 Mar 2017, In: Protein Science. 26, 3, p. 436-451 16 p.

Research output: Contribution to journal › Review › peer-review

27 Citations (Scopus)

129 Downloads (Pure)

An efficient method for estimating the hydrodynamic radius of disordered protein conformations

Nygaard, M., Kragelund, B. B., Papaleo, E. & Lindorff-Larsen, K., 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)

Hendus-Altenburger, R., Lambrughi, M., Terkelsen, T. B., Pedersen, S. H. F., Papaleo, E., Lindorff-Larsen, K. & Kragelund, B. B., Sept 2017, In: Cellular Signalling. 37, p. 40-51 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

109 Downloads (Pure)

Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

Olsen, J. G., Teilum, K. & Kragelund, B. B., 1 Sept 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

Research output: Contribution to journal › Review › peer-review

48 Citations (Scopus)

118 Downloads (Pure)

Choreography by Structural Disorder in Membrane Proteins

Kragelund, B. B., 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, suppl. 1, p. 12A 1 p., 65-Subg.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Class I Cytokine Receptors: Towards the Inside

Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, K., Brooks, A. & Kragelund, B. B., 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Cold denaturation of the HIV-1 protease monomer

Rösner, H. I., Caldarini, M., Prestel, A., Vanoni, M. A., Broglia, R. A., Aliverti, A., Tiana, G. & Kragelund, B. B., 28 Feb 2017, In: Biochemistry. 56, 8, p. 1029-1032 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication

Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira, M-F. U., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., May 2017, In: Genes. 8, 5, 14 p., 128.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

311 Downloads (Pure)

Eukaryotic transcription factors: paradigms of protein intrinsic disorder

Staby, L., O'Shea, C., Willemoës, M., Theisen, F., Kragelund, B. B. & Skriver, K., 1 Aug 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.

Research output: Contribution to journal › Review › peer-review

50 Citations (Scopus)

Functions of intrinsic disorder in transmembrane proteins

Kjærgaard, M. & Kragelund, B. B., 1 Sept 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.

Research output: Contribution to journal › Review › peer-review

30 Citations (Scopus)

Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions

He, L., Steinocher, H., Shelar, A., Cohen, E. B., Heim, E. N., Kragelund, B. B., Grigoryan, G. & DiMaio, D., 4 Sept 2017, In: eLife. 6, 28 p., e27701.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

49 Downloads (Pure)

SLiMming the fuzz in gene-regulating interactomes

Staby, L., O'Shea, C., Kragelund, B. B. & Skriver, K., 7 Nov 2017, 1 p.

Research output: Other contribution › Net publication - Internet publication › Research

Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

O'Shea, C., Staby, L., Bendsen, S. K., Tidemand, F. G., Redsted, A., Willemoës, M., Kragelund, B. B. & Skriver, K., 13 Jan 2017, In: Journal of Biological Chemistry. 292, 2, p. 512-527 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

2016

A combined computational and structural model of the full-length human prolactin receptor

Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, J. G., Lindorff-Larsen, K. & Kragelund, B. B., 13 May 2016, In: Nature Communications. 7, 11 p., 11578.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

125 Downloads (Pure)

An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

Wilkens, C., Andersen, S., Petersen, B. O., Li, A., Busse-Wicher, M., Birch, J., Cockburn, D., Nakai, H., Christensen, H. E. M., Kragelund, B. B., Dupree, P., McCleary, B., Hindsgaul, O., Abou Hachem, M. & Svensson, B., 1 Jul 2016, In: Applied Microbiology and Biotechnology. 100, 14, p. 6265-6277 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

DSS1/Sem1, a multifunctional and intrinsically disordered protein

Kragelund, B. B., Schenstrøm, S. M., Rebula, C. A., Panse, V. G. & Hartmann-Petersen, R., 1 May 2016, In: Trends in Biochemical Sciences. 41, 5, p. 446-459 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Prolactin signaling stimulates invasion via Na⁺/H⁺ exchanger NHE1 in T47D human breast cancer cells

Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, B. B. & Pedersen, S. H. F., Jul 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

The human Na⁺/H⁺ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

Hendus-Altenburger, R., Pedraz Cuesta, E., Olesen, C. W., Papaleo, E., Schnell, J. A., Hopper, J. T. S., Robinson, C. V., Pedersen, S. H. F. & Kragelund, B. B., 15 Apr 2016, In: BMC Biology. 14, 17 p., 31.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

62 Downloads (Pure)

The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove

Kragelund, B. B., Weterings, E., Hartmann-Petersen, R. & Keijzers, G., 1 Jan 2016, In: Frontiers in Bioscience. 21, 3, p. 514-527 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing?

Bugge, K. Ø., Lindorff-Larsen, K. & Kragelund, B. B., 1 Dec 2016, In: The FEBS Journal. 283, 24, p. 4424-4451 28 p.

Research output: Contribution to journal › Review › peer-review

21 Citations (Scopus)

72 Downloads (Pure)

2015

A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template

Malik, L., Nygård, J., Christensen, N. J., Madsen, C. S., Rösner, H. I., Kragelund, B. B., Høiberg-Nielsen, R., Streicher, W., Arleth, L., Thulstrup, P. W. & Jensen, K. J., 1 Sept 2015, In: ChemBioChem. 16, 13, p. 1905-1918 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

A residue quartet in the extracellular domain of the prolactin receptor selectively controls mitogen-activated protein kinase signaling

Zhang, C., Nygaard, M., Haxholm, G. W., Boutillon, F., Bernadet, M., Hoos, S., England, P., Broutin, I., Kragelund, B. B. & Goffin, V., 8 May 2015, In: Journal of Biological Chemistry. 290, 19, p. 11890-11904 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast

Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, K., Kragelund, B. B., Nielsen, M. L., Kriegenburg, F. & Hartmann-Petersen, R., 21 Aug 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy

Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, K. & Kragelund, B. B., 15 Sept 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities

Guo, Y., Kragelund, B. B., White, M. F. & Peng, X., 19 Jun 2015, In: Journal of Molecular Biology. 427, 12, p. 2179-2191 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Globular and disordered-the non-identical twins in protein-protein interactions

Teilum, K., Olsen, J. G. & Kragelund, B. B., 9 Jul 2015, In: Frontiers in Bioscience. 2, 6 p., 40.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

96 Downloads (Pure)

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

Haxholm, G. W., Nikolajsen, L. F., Olsen, J. G., Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, S. H. F., Brooks, A. J., Waters, M. J. & Kragelund, B. B., 15 Jun 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Protein intrinsic disorder in Arabidopsis NAC transcription factors: transcriptional activation by ANAC013 and ANAC046 and their interactions with RCD1

O'Shea, C., Jensen, M. K., Stender, E. G. P., Kragelund, B. B., Willemoës, M. & Skriver, K., 15 Jan 2015, In: Biochemical Journal. 465, 2, p. 281-294 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis

Zhang, C., Cherifi, I., Nygaard, M., Haxholm, G. W., Bogorad, R. L., Bernadet, M., England, P., Broutin, I., Kragelund, B. B., Guidotti, J-E. & Goffin, V., 5 Feb 2015, In: Molecular and Cellular Endocrinology. 401, p. 173-188 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Single-molecule folding mechanisms of the apo- and Mg²⁺-bound states of human neuronal calcium sensor-1

Naqvi, M. M., Heiðarsson, P. O., Otazo, M. R., Mossa, A., Kragelund, B. B. & Cecconi, C., 9 Jul 2015, In: Biophysical Journal. 109, 1, p. 113-123 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing

Marinova, I. N., Engelbrecht, J., Ewald, A., Langholm, L. L., Holmberg, C. H., Kragelund, B. B., Gordon, C., Nielsen, O. & Hartmann-Petersen, R., 6 Feb 2015, In: P L o S One. 10, 2, 15 p., e0117779.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

1062 Downloads (Pure)

Birthe Brandt Kragelund

Research output

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