R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

Peter S. Millard; Birthe B. Kragelund; Meike Burow

doi:10.1016/j.tplants.2019.07.003

R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

Peter S. Millard, Birthe B. Kragelund, Meike Burow

19 Citations (Scopus)

Abstract

Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.

Original language	English
Journal	Trends in Plant Science
Volume	24
Issue number	10
Pages (from-to)	934-946
ISSN	1360-1385
DOIs	https://doi.org/10.1016/j.tplants.2019.07.003
Publication status	Published - Oct 2019

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title = "R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain",

abstract = "Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.",

author = "Millard, {Peter S.} and Kragelund, {Birthe B.} and Meike Burow",

note = "Copyright {\textcopyright} 2019. Published by Elsevier Ltd.",

year = "2019",

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doi = "10.1016/j.tplants.2019.07.003",

language = "English",

volume = "24",

pages = "934--946",

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T1 - R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

AU - Millard, Peter S.

AU - Kragelund, Birthe B.

AU - Burow, Meike

PY - 2019/10

Y1 - 2019/10

N2 - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.

AB - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.

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DO - 10.1016/j.tplants.2019.07.003

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SP - 934

EP - 946

JO - Trends in Plant Science

JF - Trends in Plant Science

IS - 10

ER -

R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

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