Guido Keijzers

CV

Research experience

March 2015 - present       Center for Healthy Aging, Copenhagen University  (Denmark), under supervision of Prof. LJ Rasmussen.
Post Doc:       Biochemical characterization of EXO1 in replication and double strand break repair.

Nov 2013 - Feb 2015 Visiting researcher, Center for Healthy Aging, Copenhagen University (Denmark).

Jun 2010 - Nov 2013          Center for Healthy Aging, Copenhagen University (Denmark). Department of Cellular and Molecular Medicine, under supervision of Prof. LJ. Rasmussen and Dr VA. Bohr.
PhD student: Study the role of DNA-end resection proteins.

Apr 2012 - May 2012 NIH/NIA, Baltimore (USA). Laboratory of Molecular Gerontology led by Dr VA. Bohr.
Scientific exchange: Confocal studies to mismatch DNA repair proteins dynamics.

Apr 2011 - May 2011 NIH/NIA, Baltimore (USA). Laboratory of Molecular Gerontology led by Dr VA. Bohr.
Scientific exchange: Confocal studies to recruitment DNA repair proteins dynamics to DNA damage.

Jun 2009 - Jun 2010 Danish Aging Research Center, Aarhus University, (Denmark). Department of Molecular Biology under supervision of Assoc. Prof. T. Stevnsner.
Research associate: Setting up and managing a population study for biomarkers markers involved in the early on set of age related fatigue.

Apr 2008 - May 2009 NIH/NIA, Baltimore (USA). Laboratory of Molecular Gerontology led by Dr VA. Bohr.
Research associate: Study base excision repair DNA repair in primary.

Sep 2006 - Apr 2008 Erasmus MC, Rotterdam (the Netherlands). Department of Genetics, under supervision of Assoc. Prof. DC. van Gent.
Research assistant: Functional study of proteins in the DNA repair pathway non-homologous end joining.

Jun 2005 - Aug 2005          NIH/NIDDK, Bethesda (USA). Metabolic Enzymes Section led by Dr M. Gellert. Scientific exchange: In collaboration with ErasmusMC, Department of Genetics.  

Aug 2002 - Aug 2006         Erasmus MC, Rotterdam (the Netherlands). Department of Genetics, under supervision of Assoc. Prof. DC. van Gent.
Research assistant: The role of RAG proteins in transposition reporter mice.

Jan 2002 - Jul 2002 Organon NV, Oss (the Netherlands). Department of General Pharmacology under supervision of Dr T. van Dinther.
Research assistant: Assay development for immuno assays.

Jul 2000 - May 2001 Australian National University, Research School of Biological Sciences, Canberra (Australia). Department of Genomic Interactions, led by Professor BG. Rolfe.  
Bachelor/Honours of Science, Internship: Investigation into Legume model Medicago truncatula to differentially expressed proteins by use of proteomics.

Ph.D. dissertation 
Titled: DNA repair and genomic stability in aging.

Short presentation

Research focus

Survival of organisms is highly depended on the stability of mitochondrial and genomic DNA, maintained by DNA repair proteins. Deficiencies in DNA repair genes or impairment in expression level can cause increased risk of cancer as well as aging related diseases. DNA repair pathways; namely base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER) and non-homologous end-joining (NHEJ) are strongly associated with the aging process and aging related diseases. Deficiencies in DNA repair genes can lead to accumulation of DNA lesions, especially after exposure to DNA damaging reagents. Unrepaired DNA is postulated to be an underlying cause of neurodegenerative diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD).