Role of protein dynamics in transmembrane receptor signalling

TY - JOUR

T1 - Role of protein dynamics in transmembrane receptor signalling

AU - Wang, Yong

AU - Bugge, Katrine Østergaard

AU - Kragelund, Birthe Brandt

AU - Lindorff-Larsen, Kresten

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2018/2

Y1 - 2018/2

N2 - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

AB - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

KW - Journal Article

KW - Review

U2 - 10.1016/j.sbi.2017.10.017

DO - 10.1016/j.sbi.2017.10.017

M3 - Review

C2 - 29136528

SN - 0959-440X

VL - 48

SP - 74

EP - 82

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -