Arne Schousboe

2019

Astrocytic pyruvate carboxylation: Status after 35 years

Schousboe, A., Waagepetersen, H. S. & Sonnewald, U., Aug 2019, In: Journal of Neuroscience Research. 97, p. 890-896

Research output: Contribution to journal › Review › peer-review

7 Citations (Scopus)

32 Downloads (Pure)

State-Dependent Changes in Brain Glycogen Metabolism

DiNuzzo, M., Walls, A. B., Öz, G., Seaquist, E. R., Waagepetersen, H. S., Bak, L. K., Nedergaard, M. & Schousboe, A., 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2 Citations (Scopus)

Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function

Kickinger, S., Hellsberg, E., Frølund, B., Schousboe, A., Ecker, G. F. & Wellendorph, P., 15 Dec 2019, In: Neuropharmacology.

Research output: Contribution to journal › Review › peer-review

10 Citations (Scopus)

2018

Astrocytic glycogen metabolism in the healthy and diseased brain

Bak, L. K., Walls, A. B., Schousboe, A. & Waagepetersen, H. S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.

Research output: Contribution to journal › Review › peer-review

48 Citations (Scopus)

2017

Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

Schousboe, A., Wellendorph, P., Frølund, B., Clausen, R. P. & Krogsgaard-Larsen, P., 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

13 Citations (Scopus)

A Tribute to Mary C. McKenna: Glutamate as Energy Substrate and Neurotransmitter-Functional Interaction Between Neurons and Astrocytes

Schousboe, A., 1 Jan 2017, In: Neurochemical Research. 42, 1, p. 4-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS

Westergaard, N., Waagepetersen, H. S., Belhage, B. & Schousboe, A., 1 Jun 2017, In: Neurochemical Research. 42, 6, p. 1583-1588 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Delineation of the Role of Astroglial GABA Transporters in Seizure Control

Schousboe, A. & Madsen, K. K., 1 Jul 2017, In: Neurochemical Research. 42, 7, p. 2019-2023

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

Nissen, J. D., Lykke, K., Bryk, J., Stridh, M. H., Zaganas, I., Skytt, D. M., Schousboe, A., Bak, L. K., Enard, W., Pääbo, S. & Waagepetersen, H. S., 1 Mar 2017, In: Glia. 65, 3, p. 474–488

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, A., Clarkson, A. N. & Wellendorph, P., 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

15 Citations (Scopus)

Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

Parpura, V., Fisher, E. S., Lechleiter, J. D., Schousboe, A., Waagepetersen, H. S., Brunet, S., Baltan, S. & Verkhratsky, A., 1 Jan 2017, In: Neurochemical Research. 42, 1, p. 19-34 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

Jakobsen, E., Bak, L. K., Walls, A. B., Reuschlein, A-K., Schousboe, A. & Waagepetersen, H. S., 1 Sept 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-(13)C]Glucose and [1,2-(13)C]Acetate as Substrates

McNair, L. F., Kornfelt, R., Walls, A. B., Andersen, J. V., Aldana, B. I., Nissen, J. D., Schousboe, A. & Waagepetersen, H. S., 1 Mar 2017, In: Neurochemical Research. 42, 3, p. 810-826 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

Bak, L. K. & Schousboe, A., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.

Research output: Contribution to journal › Review › peer-review

14 Citations (Scopus)

Preface for the Mary C. McKenna Honorary Issue of Neurochemical Research

Schousboe, A., 2017, In: Neurochemical Research. 42, 1, 1-3.

Research output: Contribution to journal › Editorial

1 Citation (Scopus)

Preface for the Ursula Sonnewald Honorary Issue of Neurochemical Research

Schousboe, A., 2017, In: Neurochemical Research. 42, 6, p. 1581-1582 2 p.

Research output: Contribution to journal › Editorial

Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

Andersen, J. V., McNair, L. F., Schousboe, A. & Waagepetersen, H. S., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)

Jørgensen, L., Al-Khawaja, A., Kickinger, S., Vogensen, S. B., Skovgaard-Petersen, J., Rosenthal, E., Borkar, N., Löffler, R., Madsen, K. K., Bräuner-Osborne, H., Schousboe, A., Ecker, G. F., Wellendorph, P. & Clausen, R. P., 9 Nov 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8834-8846

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The 12th International Conference on Brain Energy Metabolism (ICBEM): "Energy Metabolism and Neuron-Glia Interactions in Brain: From Molecular Mechanisms to Novel Therapeutic Approaches"

Yu, A. C. H., Schousboe, A. & McKenna, M. C., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2095-2097 3 p.

Research output: Contribution to journal › Journal article › Communication

The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells

Aldana, B. I., Waagepetersen, H. S., Schousboe, A., White, H. S., Bulaj, G. & Walls, A. B., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2286-2296 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2016

40 year anniversary issue of neurochemical research

Schousboe, A., 2016, In: Neurochemical Research. 41, 1-2, p. 1-2 2 p.

Research output: Contribution to journal › Editorial

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Brekke, E., Morken, T. S., Walls, A. B., Waagepetersen, H., Schousboe, A. & Sonnewald, U., 2016, The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Springer, Vol. 13. p. 43-58 16 p. (Advances in Neurobiology, Vol. 13).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

5 Citations (Scopus)

Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

McKenna, M. C., Stridh, M. H., McNair, L. F., Sonnewald, U., Waagepetersen, H. S. & Schousboe, A., 1 Dec 2016, In: Journal of Neuroscience Research. 94, 12, p. 1561-1571 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Introduction to the Glutamate-Glutamine Cycle

Sonnewald, U. & Schousboe, A., 2016, 7 p. (Advances in Neurobiology).

Research output: Book/Report › Anthology › Research › peer-review

17 Citations (Scopus)

Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

Jayakumar, A. R., Bak, L. K., Rama Rao, K. V., Waagepetersen, H. S., Schousboe, A. & Norenberg, M. D., 4 Jan 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission

Walls, A. B., Flynn, S. P., West, P. J., Müller, M. S., Bak, L. K., Bulaj, G., Schousboe, A. & White, H. S., 1 Mar 2016, In: Epilepsy Research. 121, p. 55-63 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle

Leke, R. & Schousboe, A., 2016, 35 p. (Advances in Neurobiology).

Research output: Book/Report › Anthology › Research › peer-review

29 Citations (Scopus)

2015

AMPK Activation Affects Glutamate Metabolism in Astrocytes

Voss, C. M., Pajęcka, K., Stridh, M. H., Nissen, J. D., Schousboe, A. & Waagepetersen, H. S., 1 Dec 2015, In: Neurochemical Research. 40, 12, p. 2431-2442 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Expression of glutamine transporter isoforms in cerebral cortex of rats with chronic hepatic encephalopathy

Leke, R., Escobar, T. D. C., Rama Rao, K. V., Silveira, T. R., Norenberg, M. D. & Schousboe, A., 1 Sept 2015, In: Neurochemistry International. 88, p. 32-37 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase-deficient astrocytes

Pajęcka, K., Nissen, J. D., Stridh, M. H., Skytt, D. M., Schousboe, A. & Waagepetersen, H. S., 1 Jul 2015, In: Journal of Neuroscience Research. 93, 7, p. 1093-100 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Glutamate and ATP: The crossroads of signaling and metabolism in the brain.

Verkhratsky, A., Schousboe, A. & Parpura, V., 2015, Advances in Neurobiology. Schousboe, A. (ed.). USA: Springer Publishing Company, Vol. 11. p. 1-12 12 p. (Advances in Neurobiology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

Glutamate neurotransmission is affected in prenatally stressed offspring

Adrover, E., Pallarés, M. E., Baier, C. J., Monteleone, M. C., Giuliani, F. A., Waagepetersen, H. S., Brocco, M. A., Cabrera, R., Sonnewald, U., Schousboe, A. & Antonelli, M. C., 1 Sept 2015, In: Neurochemistry International. 88, p. 73-87 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Glutamine and ammonia in hepatic encephalopathy

Dadsetan, S., Waagepetersen, H. S., Schousboe, A. & Bak, L. K., 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

3 Citations (Scopus)

Structure activity relationship of selective GABA uptake inhibitors

Vogensen, S. B., Jørgensen, L., Madsen, K. K., Jurik, A., Borkar, N., Rosatelli, E., Nielsen, B., Ecker, G. F., Schousboe, A. & Clausen, R. P., 15 May 2015, In: Bioorganic & Medicinal Chemistry. 23, 10, p. 2480-2488 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

The 11th International Conference on Brain Energy Metabolism "how energy metabolism shapes brain function". Preface: Preface

Waagepetersen, H., Schousboe, A. & McKenna, M. C., 1 Jul 2015, In: Journal of Neuroscience Research. 93, 7, p. 985-6 2 p.

Research output: Contribution to journal › Journal article › Research

Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?

Bak, L., Mueller, M. S., Fox, R., Pedersen, S. E., Walls, A. B., Reuschlein, A. -K., Jakobsen, E., Schousboe, A. & Waagepetersen, H. S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

7 Citations (Scopus)

2014

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

Müller, M. S., Fox, R., Schousboe, A., Waagepetersen, H. S. & Bak, L. K., Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo

Walls, A. B., Eyjolfsson, E. M., Schousboe, A., Sonnewald, U. & Waagepetersen, H. S., Aug 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1340-6 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Brain glycogen: emergency fuel and dynamic function in neurotransmission

Walls, A. B. & Schousboe, A., Feb 2014, In: Metabolic Brain Disease. 30, 1, p. 249-249 1 p.

Research output: Contribution to journal › Journal article › Research

1 Citation (Scopus)

Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

Fries, A. W., Dadsetan, S., Keiding, S., Bak, L. K., Schousboe, A., Waagepetersen, H. S., Simonsen, M., Ott, P., Vilstrup, H. & Sørensen, M., Mar 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 460-6 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Schousboe, A., Waagepetersen, H. S., Leke, R. & Bak, L. K., 13 Nov 2014, In: Metabolic Brain Disease. 29, 4, p. 913-917 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Expression of glutamate decarboxylase (GAD) mRNA in the brain of bile duct ligated rats serving as a model of hepatic encephalopathy

Leke, R., Silveira, T., Escobar, T. & Schousboe, A., Mar 2014, In: Neurochemical Research. 39, 3, p. 605-611 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, L. K., Schousboe, A., Plaitakis, A. & Waagepetersen, H. S., Mar 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, L. K., Schousboe, A., Plaitakis, A. & Waagepetersen, H. S., Mar 2014, In: Neurochemical Research. 39, 3, p. 487-499

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Glutamate metabolism in the brain focusing on astrocytes

Schousboe, A., Scafidi, S., Bak, L. K., Waagepetersen, H. S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Introduction to special issue in honor of Professor Povl Krogsgaard-Larsen

Bräuner-Osborne, H. & Schousboe, A., 1 Oct 2014, In: Neurochemical Research. 39, 10, p. 1845-6 2 p.

Research output: Contribution to journal › Journal article › Research

Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)

Walls, A. B., Bak, L. K., Sonnewald, U., Schousboe, A. & Waagepetersen, H. S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, L. K., Waagepetersen, H. S., Schousboe, A., Ott, P., Vilstrup, H., Keiding, S. & Gjedde, A., 2014, In: Frontiers in Neuroscience. 8, p. 353

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

37 Downloads (Pure)

The GABA Synapse as a Target for Antiepileptic Drugs: A Historical Overview Focused on GABA Transporters

Schousboe, A., Madsen, K. K., Barker-Haliski, M. L. & White, H. S., 24 Sept 2014, In: Neurochemical Research. 39, 10, p. 1980-1987 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

The Glutamine-Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

Walls, A. B., Waagepetersen, H. S., Bak, L. K., Schousboe, A. & Sonnewald, U., Feb 2014, In: Neurochemical Research. 40, 2, p. 402-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

Arne Schousboe

Research output

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