Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Eva Brekke; Tora Sund Morken; Anne B Walls; Helle Waagepetersen; Arne Schousboe; Ursula Sonnewald

doi:10.1007/978-3-319-45096-4_3

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Eva Brekke, Tora Sund Morken, Anne B Walls, Helle Waagepetersen, Arne Schousboe, Ursula Sonnewald

5 Citations (Scopus)

Abstract

A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine–glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

Original language	English
Title of host publication	The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis
Number of pages	16
Volume	13
Publisher	Springer
Publication date	2016
Pages	43-58
Chapter	3
ISBN (Electronic)	978-3-319-45096-4
DOIs	https://doi.org/10.1007/978-3-319-45096-4_3
Publication status	Published - 2016

Series	Advances in Neurobiology
Volume	13
ISSN	2190-5215

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Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. / Brekke, Eva; Morken, Tora Sund; Walls, Anne B et al.

The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Vol. 13 Springer, 2016. p. 43-58 (Advances in Neurobiology, Vol. 13).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Abstract

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