Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Arne Schousboe; Helle S. Waagepetersen; Renata Leke; Lasse K Bak

doi:10.1007/s11011-014-9513-8

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Arne Schousboe, Helle S. Waagepetersen, Renata Leke, Lasse K Bak

13 Citations (Scopus)

Abstract

The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

Original language	English
Journal	Metabolic Brain Disease
Volume	29
Issue number	4
Pages (from-to)	913-917
Number of pages	5
ISSN	0885-7490
DOIs	https://doi.org/10.1007/s11011-014-9513-8
Publication status	Published - 13 Nov 2014

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title = "Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro",

abstract = "The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.",

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AU - Schousboe, Arne

AU - Waagepetersen, Helle S.

AU - Leke, Renata

AU - Bak, Lasse K

PY - 2014/11/13

Y1 - 2014/11/13

N2 - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

AB - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

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Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Abstract

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