Glutamine and ammonia in hepatic encephalopathy

Sherry Dadsetan; Helle S. Waagepetersen; Arne Schousboe; Lasse K. Bak

doi:10.1007/978-1-4939-1932-1_17

Glutamine and ammonia in hepatic encephalopathy

Sherry Dadsetan, Helle S. Waagepetersen, Arne Schousboe, Lasse K. Bak^*

^*Corresponding author for this work

3 Citations (Scopus)

Abstract

The amino acid glutamine is present in all tissues and it serves several purposes depending on the tissue in question. This chapter is devoted to a discussion of its role in relation to the elevated ammonia levels found in the brain in the context of hepatic encephalopathy (HE), a disturbance of the central nervous system due to liver failure [1] characterized by cognitive, psychiatric, and motor deficits. Early symptoms include reversal of sleep pattern, apathy, hypersomnia, irritability, and personal neglect and HE can progressively lead to coma and death [2]. Brain ammonia homeostasis is functionally associated with metabolism in the liver since this organ is responsible for removal of excess ammonia from the bloodstream. Thus, this chapter is intended to focus on glutamine metabolism in these two organs.

Original language	English
Title of host publication	Glutamine in Clinical Nutrition
Number of pages	9
Publisher	Springer New York LLC
Publication date	1 Jan 2015
Pages	219-227
ISBN (Print)	9781493919314
ISBN (Electronic)	9781493919321
DOIs	https://doi.org/10.1007/978-1-4939-1932-1_17
Publication status	Published - 1 Jan 2015

Keywords

Alanine
Astrocyte
Glutamine
Hepatic encephalopathy
Neuron

Access to Document

10.1007/978-1-4939-1932-1_17

Cite this

@inbook{68988bac6ef147f5bfa6356aed281d22,

title = "Glutamine and ammonia in hepatic encephalopathy",

abstract = "The amino acid glutamine is present in all tissues and it serves several purposes depending on the tissue in question. This chapter is devoted to a discussion of its role in relation to the elevated ammonia levels found in the brain in the context of hepatic encephalopathy (HE), a disturbance of the central nervous system due to liver failure [1] characterized by cognitive, psychiatric, and motor deficits. Early symptoms include reversal of sleep pattern, apathy, hypersomnia, irritability, and personal neglect and HE can progressively lead to coma and death [2]. Brain ammonia homeostasis is functionally associated with metabolism in the liver since this organ is responsible for removal of excess ammonia from the bloodstream. Thus, this chapter is intended to focus on glutamine metabolism in these two organs.",

keywords = "Alanine, Astrocyte, Glutamine, Hepatic encephalopathy, Neuron",

author = "Sherry Dadsetan and Waagepetersen, {Helle S.} and Arne Schousboe and Bak, {Lasse K.}",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-1-4939-1932-1_17",

language = "English",

isbn = "9781493919314",

pages = "219--227",

booktitle = "Glutamine in Clinical Nutrition",

publisher = "Springer New York LLC",

}

TY - CHAP

T1 - Glutamine and ammonia in hepatic encephalopathy

AU - Dadsetan, Sherry

AU - Waagepetersen, Helle S.

AU - Schousboe, Arne

AU - Bak, Lasse K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The amino acid glutamine is present in all tissues and it serves several purposes depending on the tissue in question. This chapter is devoted to a discussion of its role in relation to the elevated ammonia levels found in the brain in the context of hepatic encephalopathy (HE), a disturbance of the central nervous system due to liver failure [1] characterized by cognitive, psychiatric, and motor deficits. Early symptoms include reversal of sleep pattern, apathy, hypersomnia, irritability, and personal neglect and HE can progressively lead to coma and death [2]. Brain ammonia homeostasis is functionally associated with metabolism in the liver since this organ is responsible for removal of excess ammonia from the bloodstream. Thus, this chapter is intended to focus on glutamine metabolism in these two organs.

AB - The amino acid glutamine is present in all tissues and it serves several purposes depending on the tissue in question. This chapter is devoted to a discussion of its role in relation to the elevated ammonia levels found in the brain in the context of hepatic encephalopathy (HE), a disturbance of the central nervous system due to liver failure [1] characterized by cognitive, psychiatric, and motor deficits. Early symptoms include reversal of sleep pattern, apathy, hypersomnia, irritability, and personal neglect and HE can progressively lead to coma and death [2]. Brain ammonia homeostasis is functionally associated with metabolism in the liver since this organ is responsible for removal of excess ammonia from the bloodstream. Thus, this chapter is intended to focus on glutamine metabolism in these two organs.

KW - Alanine

KW - Astrocyte

KW - Glutamine

KW - Hepatic encephalopathy

KW - Neuron

UR - http://www.scopus.com/inward/record.url?scp=84944535773&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1932-1_17

DO - 10.1007/978-1-4939-1932-1_17

M3 - Book chapter

AN - SCOPUS:84944535773

SN - 9781493919314

SP - 219

EP - 227

BT - Glutamine in Clinical Nutrition

PB - Springer New York LLC

ER -

Glutamine and ammonia in hepatic encephalopathy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this