State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo; Anne B. Walls; Gülin Öz; Elizabeth R. Seaquist; Helle S. Waagepetersen; Lasse K. Bak; Maiken Nedergaard; Arne Schousboe

doi:10.1007/978-3-030-27480-1_9

State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo^*, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

Original language	English
Title of host publication	Brain Glycogen Metabolism
Editors	Mauro DiNuzzo, Arne Schousboe
Number of pages	41
Publisher	Springer
Publication date	2019
Pages	269-309
ISBN (Print)	978-3-030-27479-5
ISBN (Electronic)	978-3-030-27480-1
DOIs	https://doi.org/10.1007/978-3-030-27480-1_9
Publication status	Published - 2019

Series	Advances in Neurobiology
Volume	23
ISSN	2190-5215

Keywords

Astrocyte-neuron interactions
Brain state
Glycogen β-particle
Ion homeostasis
Metabolic compartmentation

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10.1007/978-3-030-27480-1_9

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AU - Öz, Gülin

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AU - Bak, Lasse K.

AU - Nedergaard, Maiken

AU - Schousboe, Arne

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KW - Astrocyte-neuron interactions

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KW - Ion homeostasis

KW - Metabolic compartmentation

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State-Dependent Changes in Brain Glycogen Metabolism

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Keywords

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