Astrocytic pyruvate carboxylation: Status after 35 years

Arne Schousboe; Helle S. Waagepetersen; Ursula Sonnewald

doi:10.1002/jnr.24402

Astrocytic pyruvate carboxylation: Status after 35 years

Arne Schousboe^*, Helle S. Waagepetersen, Ursula Sonnewald

^*Corresponding author for this work

7 Citations (Scopus)

32 Downloads (Pure)

Abstract

The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

Original language	English
Journal	Journal of Neuroscience Research
Volume	97
Pages (from-to)	890-896
ISSN	0360-4012
DOIs	https://doi.org/10.1002/jnr.24402
Publication status	Published - Aug 2019

Keywords

anaplerosis
astrocytes
cataplerosis
glutamate
glutamine
neurons

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title = "Astrocytic pyruvate carboxylation: Status after 35 years",

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AU - Waagepetersen, Helle S.

AU - Sonnewald, Ursula

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N2 - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

AB - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

KW - anaplerosis

KW - astrocytes

KW - cataplerosis

KW - glutamate

KW - glutamine

KW - neurons

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ER -

Astrocytic pyruvate carboxylation: Status after 35 years

Abstract

Keywords

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