Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

TY - JOUR

T1 - Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia

T2 - Examples from Pathology

AU - Parpura, Vladimir

AU - Fisher, Elizabeth S

AU - Lechleiter, James D

AU - Schousboe, Arne

AU - Waagepetersen, Helle S

AU - Brunet, Sylvain

AU - Baltan, Selva

AU - Verkhratsky, Alexei

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Glutamate is the main excitatory transmitter in the brain, while ATP represents the most important energy currency in any living cell. Yet, these chemicals play an important role in both processes, enabling them with dual-acting functions in metabolic and intercellular signaling pathways. Glutamate can fuel ATP production, while ATP can act as a transmitter in intercellular signaling. We discuss the interface between glutamate and ATP in signaling and metabolism of astrocytes. Not only do glutamate and ATP cross each other’s paths in physiology of the brain, but they also do so in its pathology. We present the fabric of this process in (patho)physiology through the discussion of synthesis and metabolism of ATP and glutamate in astrocytes as well as by providing a general description of astroglial receptors for these molecules along with the downstream signaling pathways that may be activated. It is astroglial receptors for these dual-acting molecules that could hold a key for medical intervention in pathological conditions. We focus on two examples disclosing the role of activation of astroglial ATP and glutamate receptors in pathology of two kinds of brain tissue, gray matter and white matter, respectively. Interventions at the interface of metabolism and signaling show promise for translational medicine.

AB - Glutamate is the main excitatory transmitter in the brain, while ATP represents the most important energy currency in any living cell. Yet, these chemicals play an important role in both processes, enabling them with dual-acting functions in metabolic and intercellular signaling pathways. Glutamate can fuel ATP production, while ATP can act as a transmitter in intercellular signaling. We discuss the interface between glutamate and ATP in signaling and metabolism of astrocytes. Not only do glutamate and ATP cross each other’s paths in physiology of the brain, but they also do so in its pathology. We present the fabric of this process in (patho)physiology through the discussion of synthesis and metabolism of ATP and glutamate in astrocytes as well as by providing a general description of astroglial receptors for these molecules along with the downstream signaling pathways that may be activated. It is astroglial receptors for these dual-acting molecules that could hold a key for medical intervention in pathological conditions. We focus on two examples disclosing the role of activation of astroglial ATP and glutamate receptors in pathology of two kinds of brain tissue, gray matter and white matter, respectively. Interventions at the interface of metabolism and signaling show promise for translational medicine.

U2 - 10.1007/s11064-016-1848-6

DO - 10.1007/s11064-016-1848-6

M3 - Journal article

C2 - 26915104

SN - 0364-3190

VL - 42

SP - 19

EP - 34

JO - Neurochemical Research

JF - Neurochemical Research

IS - 1

ER -