Anette Müllertz

2016

Polymeric microcontainers improve oral bioavailability of furosemide

Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, J., Garrigues, T., Rades, T., Müllertz, A. & Boisen, A., 17 maj 2016, I: International Journal of Pharmaceutics. 504, 1-2, s. 98-109 12 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

39 Citationer (Scopus)

Rhamnogalacturonan-I based microcapsules for targeted drug release

Svagan, A. J., Kusic, A., De Gobba, C., Larsen, F. H., Sassene, P., Zhou, Q., Van De Weert, M., Mullertz, A., Jørgensen, B. & Ulvskov, P., 2016, I: P L o S One. 11, 12, 13 s., e0168050.

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9 Citationer (Scopus)

140 Downloads (Pure)

Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

Svagan, A. J., Benjamins, J.-W., Al-Ansari, Z., Shalom, D. B., Müllertz, A., Wågberg, L. & Löbmann, K., 28 dec. 2016, I: Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, s. 74–82 9 s.

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34 Citationer (Scopus)

Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

Palmelund, H., Madsen, C. M., Christensen, J. P., Müllertz, A. & Rades, T., 1 okt. 2016, I: Journal of Pharmaceutical Sciences. 105, 10, s. 3021-3029 9 s.

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33 Citationer (Scopus)

Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

Madsen, C. M., Boyd, B., Rades, T. & Müllertz, A., 25 aug. 2016, I: European Journal of Pharmaceutical Sciences. 91, s. 31-39 9 s.

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12 Citationer (Scopus)

Survival of Lactobacillus acidophilus NCFM^® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

Klindt-Toldam, S., Larsen, S. K., Saaby, L., Olsen, L. R., Svenstrup, G., Müllertz, A., Knøchel, S., Heimdal, H., Nielsen, D. S. & Zielińska, D., 2016, I: Lebensmittel - Wissenschaft und Technologie. 74, s. 404-410 7 s.

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27 Citationer (Scopus)

The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, A. & Rades, T., 1 jan. 2016, I: The A A P S Journal. 18, 1, s. 180-186 7 s.

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28 Citationer (Scopus)

2015

Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems

Mosgaard, M. D., Sassene, P., Mu, H., Rades, T. & Müllertz, A., 15 jul. 2015, I: European Journal of Pharmaceutics and Biopharmaceutics. 94, s. 493-500 8 s.

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25 Citationer (Scopus)

Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system

Sassene, P. J., Mosgaard, M. D., Löbmann, K., Mu, H., Larsen, F. H., Rades, T. & Müllertz, A., 22 sep. 2015, I: Molecular Pharmaceutics. 12, 11, s. 4067-4076 10 s.

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25 Citationer (Scopus)

Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans

Christiansen, M. L., Müllertz, A., Garmer, M., Kristensen, J., Jacobsen, J., Abrahamsson, B. & Holm, R., jan. 2015, I: Journal of Pharmaceutical Sciences. 104, 1, s. 135-143 9 s.

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8 Citationer (Scopus)

Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

Berthelsen, R., Holm, R., Jacobsen, J., Kristensen, J., Abrahamsson, B. & Müllertz, A., 13 feb. 2015, I: Molecular Pharmaceutics. 12, 4, s. 1062-1071 10 s.

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27 Citationer (Scopus)

Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

Borkar, N. N., Li, B., Holm, R., Håkansson, A., Müllertz, A., Yang, M. & Mu, H., jan. 2015, I: European Journal of Pharmaceutics and Biopharmaceutics. 89, s. 216-223 8 s.

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31 Citationer (Scopus)

Marine lipids and the bioavailability of omega-3 fatty acids

Mu, H. & Müllertz, A., 1 jul. 2015, I: Current Nutrition and Food Science. 11, 3, s. 177-187 11 s.

Publikation: Bidrag til tidsskrift › Review › peer review

4 Citationer (Scopus)

pH-triggered drug release from biodegradable microwells for oral drug delivery

Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, J., Rades, T., Müllertz, A. & Boisen, A., 22 jun. 2015, I: Biomedical Microdevices. 17, 7 s., 55.

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23 Citationer (Scopus)

Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

Nielsen, L. H., Rades, T. & Müllertz, A., 25 jul. 2015, I: International Journal of Pharmaceutics. 490, 1-2, s. 334-40 7 s.

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18 Citationer (Scopus)

Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

Bøgh, M., García-Díaz, M., Müllertz, A. & Nielsen, H. M., 1 sep. 2015, I: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, s. 136–143 8 s.

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28 Citationer (Scopus)

Structural features of colloidal species in the human fasted upper small intestine

Mullertz, A., Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., mar. 2015, I: Journal of Pharmacy and Pharmacology. 67, 4, s. 486-492 7 s.

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15 Citationer (Scopus)

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

Bakala-N'Goma, J.-C., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Müllertz, A., Pouton, C. W., Porter, C. J. H. & Carriere, F., apr. 2015, I: Pharmaceutical Research. 32, 4, s. 1279-1287 9 s.

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42 Citationer (Scopus)

2014

A slow cooling rate of indomethacin melt spatially confined in microcontainers increases the physical stability of the amorphous drug without influencing its biorelevant dissolution behaviour

Nielsen, L. H., Keller, S. S., Boisen, A., Müllertz, A. & Rades, T., jun. 2014, I: Drug Delivery and Translational Research. 4, 3, s. 268-74 7 s.

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8 Citationer (Scopus)

Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

Meng-Lund, E., Jacobsen, J., Jin, L., Janfelt, C., Holm, R., Müllertz, A. & Nicolazzo, J. A., apr. 2014, I: Journal of Pharmaceutical Sciences. 103, 4, s. 1133-1141 103.

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10 Citationer (Scopus)

Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)

Christiansen, M. L., Holm, R., Kristensen, J., Kreilgaard, M., Jacobsen, J., Abrahamsson, B. & Müllertz, A., 16 jun. 2014, I: European Journal of Pharmaceutical Sciences. 57, s. 164-172

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30 Citationer (Scopus)

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

Berthelsen, R., Sjögren, E., Jacobsen, J., Kristensen, J., Holm, R., Abrahamsson, B. & Müllertz, A., 1 okt. 2014, I: International Journal of Pharmaceutics. 473, 1-2, s. 356-365 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs

Bergström, C. A. S., Holm, R., Jørgensen, S. A., Andersson, S. B. E., Artursson, P., Beato, S., Borde, A., Box, K., Brewster, M., Dressman, J., Feng, K.-I., Halbert, G., Kostewicz, E., McAllister, M., Muenster, U., Thinnes, J., Taylor, R. & Mullertz, A., 16 jun. 2014, I: European Journal of Pharmaceutical Sciences. 57, s. 173-99 27 s.

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177 Citationer (Scopus)

Ex Vivo Correlation of the Permeability of Metoprolol Across Human and Porcine Buccal Mucosa

Meng-Lund, E., Marxen, E., Pedersen, A. M. L., Müllertz, A., Hyrup, B., Holm, R. & Jacobsen, J., jul. 2014, I: Journal of Pharmaceutical Sciences. 103, 7, s. 2053-2061 8 s.

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11 Citationer (Scopus)

Feasibility of Capsule Endoscopy for Direct Imaging of Drug Delivery Systems in the Fasted Upper-Gastrointestinal Tract

Pedersen, P. B., Bar-Shalom, D., Baldursdottir, S., Vilmann, P. & Müllertz, A., aug. 2014, I: Pharmaceutical Research. 31, 8, s. 2044-2053 10 s.

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11 Citationer (Scopus)

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

Christophersen, P. C. B., Christiansen, M. L., Holm, R., Kristensen, J., Jacobsen, J., Abrahamsson, B. & Müllertz, A., 16 jun. 2014, I: European Journal of Pharmaceutical Sciences. 57, s. 232-239

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48 Citationer (Scopus)

Impact of sodium dodecyl sulphate on the dissolution of poorly soluble drug into biorelevant medium from drug-surfactant discs

Madelung, P., Ostergaard, J., Bertelsen, P., Jørgensen, E. V., Jacobsen, J. & Müllertz, A., 5 jun. 2014, I: International Journal of Pharmaceutics. 467, 1-2, s. 1-8

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6 Citationer (Scopus)

Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

Borkar, N. N., Xia, D., Holm, R., Gan, Y., Müllertz, A., Yang, M. & Mu, H., 2014, I: European Journal of Pharmaceutical Sciences. 51, s. 204-10 7 s.

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30 Citationer (Scopus)

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

Heshmati, N., Cheng, X., Dapat, E., Sassene, P., Eisenbrand, G., Fricker, G. & Müllertz, A., nov. 2014, I: The Journal of pharmacy and pharmacology. 66, 11, s. 1567-75 11 s.

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13 Citationer (Scopus)

In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

Thomas, N., Richter, K., Pedersen, T. B., Holm, R., Müllertz, A. & Rades, T., maj 2014, I: A A P S Journal. 16, 3, s. 539-549

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80 Citationer (Scopus)

In vitro models for the prediction of in vivo performance of oral dosage forms

Kostewicz, E. S., Abrahamsson, B., Brewster, M., Brouwers, J., Butler, J., Carlert, S., Dickinson, P. A., Dressman, J., Holm, R., Klein, S., Mann, J., McAllister, M., Minekus, M., Muenster, U., Müllertz, A., Verwei, M., Vertzoni, M., Weitschies, W. & Augustijns, P., 16 jun. 2014, I: European Journal of Pharmaceutical Sciences. 57, s. 342-66 25 s.

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234 Citationer (Scopus)

Miniaturized approach for excipient selection during the development of oral solid dosage form

Raijada, D. K., Müllertz, A., Cornett, C., Munk, T., Sonnergaard, J. & Rantanen, J., mar. 2014, I: Journal of Pharmaceutical Sciences. 103, 3, s. 900-8 9 s.

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5 Citationer (Scopus)

Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

Marizza, P., Keller, S. S., Müllertz, A. & Boisen, A., 10 jan. 2014, I: Journal of controlled release : official journal of the Controlled Release Society. 173, s. 1-9 9 s.

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44 Citationer (Scopus)

Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

Bøgh, M., Baldursdóttir, S. G., Müllertz, A. & Nielsen, H. M., jul. 2014, I: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, s. 227-235 9 s.

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65 Citationer (Scopus)

Refining stability and dissolution rate of amorphous drug formulations

Grohganz, H., Priemel, P. A., Löbmann, K., Nielsen, L. H., Laitinen, R., Mullertz, A., Van den Mooter, G. & Rades, T., jun. 2014, I: Expert Opinion on Drug Delivery. 11, 6, s. 977-89 13 s.

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90 Citationer (Scopus)

Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

Li, P., Tan, A., Prestidge, C. A., Nielsen, H. M. & Müllertz, A., 30 dec. 2014, I: International Journal of Pharmaceutics. 477, 1-2, s. 390-8 9 s.

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59 Citationer (Scopus)

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

Christophersen, P. C., Vaghela, D., Müllertz, A., Yang, M., Nielsen, H. M. & Mu, H., jul. 2014, I: A A P S Journal. 16, 4, s. 875-83 9 s.

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8 Citationer (Scopus)

Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

Christophersen, P. C., Zhang, L., Müllertz, A., Nielsen, H. M., Yang, M. & Mu, H., 13 mar. 2014, I: Pharmaceutical Research. 31, 9, s. 2420-28 9 s.

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28 Citationer (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Müllertz, A., Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, aug. 2014, I: Journal of Pharmaceutical Sciences. 103, 8, s. 2441-55 15 s.

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27 Citationer (Scopus)

Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

Christophersen, P., Vaghela, D., Müllertz, A., Yang, M., Nielsen, H. M. & Mu, H., 2014.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

2013

A new approach to dissolution testing by UV imaging and finite element simulations

Bøtker, J. P., Rantanen, J., Rades, T., Müllertz, A., Ostergaard, J. & Jensen, H., maj 2013, I: Pharmaceutical Research. 30, 5, s. 1328-1337

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30 Citationer (Scopus)

Bile salts and their importance for drug absorption

Holm, R., Müllertz, A. & Mu, H., 30 aug. 2013, I: International Journal of Pharmaceutics. 453, 1, s. 44-55 12 s.

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128 Citationer (Scopus)

Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis

Larsen, A. T., Åkesson, P., Juréus, A., Saaby, L., Abu-Rmaileh, R., Abrahamsson, B., Østergaard, J. & Müllertz, A., dec. 2013, I: Pharmaceutical Research. 30, 12, s. 3101-13 13 s.

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26 Citationer (Scopus)

Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

Nielsen, L. H., Gordon, S., Pajander, J. P., Østergaard, J., Rades, T. & Müllertz, A., 30 nov. 2013, I: International Journal of Pharmaceutics. 457, 1, s. 14-24 11 s.

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25 Citationer (Scopus)

Characterization during storage and dissolution of Solid dispersions containing furosemide and hydroxypropyl methylcellulose

Nielsen, L. H., Rades, T. & Müllertz, A., 1 jul. 2013, I: Journal of Drug Delivery Science and Technology. 23, 4, s. 409-415 7 s.

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5 Citationer (Scopus)

Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

Pedersen, P. B., Vilmann, P., Bar-Shalom, D., Müllertz, A. & Baldursdottir, S., nov. 2013, I: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Pt B, s. 958-65 8 s.

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50 Citationer (Scopus)

Development and rheological profiling of biosimilar mucus

Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Müllertz, A. & Nielsen, H. M., 2013, I: Nordic Rheology Society Annual Transactions. 21, s. 233-240

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Ex vivo - correlation of the absorption of metoprolol through human and porcine buccal mucosa at varying pH.

Meng-Lund, E., Marxen, E., Pedersen, A. M. L., Müllertz, A., Holm, R., Hyrup, B. & Jacobsen, J., 4 mar. 2013.

Publikation: Konferencebidrag › Poster › Forskning › peer review

In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products

Devraj, R., Williams, H. D., Warren, D. B., Mullertz, A., Porter, C. J. H. & Pouton, C. W., 30 jan. 2013, I: International Journal of Pharmaceutics. 441, 1-2, s. 323-333

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84 Citationer (Scopus)

Lipid-based formulations for oral administration of poorly water-soluble drugs

Mu, H., Holm, R. & Müllertz, A., 30 aug. 2013, I: International Journal of Pharmaceutics. 453, 1, s. 215-24 10 s.

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190 Citationer (Scopus)

Anette Müllertz

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