Lipid-based formulations for oral administration of poorly water-soluble drugs

Huiling Mu; René Holm; Anette Müllertz

doi:10.1016/j.ijpharm.2013.03.054

Lipid-based formulations for oral administration of poorly water-soluble drugs

190 Citationer (Scopus)

Abstract

Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.

Originalsprog	Engelsk
Tidsskrift	International Journal of Pharmaceutics
Vol/bind	453
Udgave nummer	1
Sider (fra-til)	215-24
Antal sider	10
ISSN	0378-5173
DOI	https://doi.org/10.1016/j.ijpharm.2013.03.054
Status	Udgivet - 30 aug. 2013

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10.1016/j.ijpharm.2013.03.054

Citationsformater

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AB - Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.

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Lipid-based formulations for oral administration of poorly water-soluble drugs

Abstract

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