TY - JOUR
T1 - Lipid-based formulations for oral administration of poorly water-soluble drugs
AU - Mu, Huiling
AU - Holm, René
AU - Müllertz, Anette
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.
AB - Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.
U2 - 10.1016/j.ijpharm.2013.03.054
DO - 10.1016/j.ijpharm.2013.03.054
M3 - Journal article
C2 - 23578826
SN - 0378-5173
VL - 453
SP - 215
EP - 224
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -