A new approach to dissolution testing by UV imaging and finite element simulations

TY - JOUR

T1 - A new approach to dissolution testing by UV imaging and finite element simulations

AU - Bøtker, Johan Peter

AU - Rantanen, Jukka

AU - Rades, Thomas

AU - Müllertz, Anette

AU - Ostergaard, Jesper

AU - Jensen, Henrik

PY - 2013/5

Y1 - 2013/5

N2 - PURPOSE: Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved temporally and spatially information on the dissolution process. In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution. METHODS: The dissolution process was monitored by both effluent collection and UV imaging of compacts of paracetamol. A finite element model (FEM) was used to characterize the UV imaging system. RESULTS: A finite element model of the UV imaging system was successfully built. The dissolution of paracetamol was studied by UV imaging and by analysis of the effluent. The dissolution rates obtained from the collected effluent were in good agreement with the numerical model. The numerical model allowed an assessment of the ability of the UV imager to measure dissolution-time profiles. The simulation was able to extend the experimental results to conditions not easily obtained experimentally. CONCLUSIONS: Combining FEM,experimental dissolution data and UV imaging provided experimental validation of the FEM model as well as a detailed description of the dissolution process.

AB - PURPOSE: Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved temporally and spatially information on the dissolution process. In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution. METHODS: The dissolution process was monitored by both effluent collection and UV imaging of compacts of paracetamol. A finite element model (FEM) was used to characterize the UV imaging system. RESULTS: A finite element model of the UV imaging system was successfully built. The dissolution of paracetamol was studied by UV imaging and by analysis of the effluent. The dissolution rates obtained from the collected effluent were in good agreement with the numerical model. The numerical model allowed an assessment of the ability of the UV imager to measure dissolution-time profiles. The simulation was able to extend the experimental results to conditions not easily obtained experimentally. CONCLUSIONS: Combining FEM,experimental dissolution data and UV imaging provided experimental validation of the FEM model as well as a detailed description of the dissolution process.

U2 - 10.1007/s11095-013-0972-0

DO - 10.1007/s11095-013-0972-0

M3 - Journal article

C2 - 23307418

SN - 0724-8741

VL - 30

SP - 1328

EP - 1337

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 5

ER -