Mingshi Yang

Kort præsentation

Short prosentation

Mingshi Yang received his Ph.D. from Shenyang Pharmaceutical University, China, in 2003, and then conducted postdoctoral research in Gifu Pharmaceutical University, Japan (2003-2005) and The Danish University of Pharmaceutical Sciences (2005-2006), respectively. After having worked as a research scientist in Novo Nordisk A/S (2006-2009), he took up the current position in University of Copenhagen in June 2009. His research has been focused on engineering micro/nanoparticles to improve delivery of both biopharmaceuticals and small molecule therapeutics via various administration routes. He is a board member of two international peer-reviewed scientific journals, and Chinese Society of Particuology - Bioparticle Association, also serves as a reviewer for more than 20 international scientific journals. He received a senior visiting scholarship from Fudan University (2014-2015), and received Pan Deng Scholar from Liaoning Province, China, 2015.

Primære forskningsområder

Micro/nanoparticulate systems may provide bio-actives with a few functionalities, e.g. targeted delivery, extended effects, improved stability, enhanced solubility, enhanced bioavailability and reduced side effects, which are desired for various medical uses such as drug delivery, tissue engineering and new therapies. Mechanistic understanding of the formation process of the micro/nanoparticles and their impact on bio-environment is essential for rational design of these systems. My research interests include understanding physical and chemical mechanisms that determine the engineering of aforementioned micro/nanoparticulate systems with optimal functionalities, the interplay between the micro/nanoparticulates and bio-membranes or cells, as well as the mechanisms that control the release of the bio-actives from the micro/nanoparticulate systems.

Aktuel forskning

The current research is focused on engineering of micro/nanoparticles or nano-composite particles via wet chemistry or atomization technologies including spray-drying, spray freeze-drying and electrospraying/electrospinning for respiratory, peroral or subcutaneous administration of poorly water-soluble drugs, protein/peptide drugs and siRNA. Another emphasis of the current research is placed on characterization of the physical and chemical stability of the protein and peptide drugs upon the processing.

Projects ongoing:

PhD projects

• Electorhydrodynamic technique based personalized medicine: a concept pf continuous manufacturing for micro-solid dosage form (Xiaoli Liu, 2014-2017) main supervisor
• Mechanistic understanding of the interaction of pharmaceutical polypeptides and lipophilic/hydrophilic excipients during processing and in vitro assay (Shuying Ji, 2013-2016) main supervisor
• Porous silicon based particulate drug delivery system for oral delivery of proteins and peptides for diabetes therapy (Neha Shrestha, 2013-2016) co-supervisor in collaboration with University of Helsinki
• A lipid based drug delivery strategy for improving efficacy of apomorphine for neurodegeneration associated with Parkinson’s disease (Nrupa Borkar, 2013-2016) co-supervisor
• Understanding the role of lipid excipients in oral delivery of biopharmaceuticals (Philip C.B. Christophersen, 2011-2014) co-supervisor
• Rational design of particulate delivery system for biopharmaceuticals (Feng Wan, 2011-2014) main supervisor
• Design of functional lipid nanoparticles for oral delivery of protein/peptide drugs and study of absorption mechanism (Xiuying Li, 2010-2014) co-supervisor in collaboration with Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Postdoc project

• Design and formulation of multifunctional nanostructured particles for local pulmonary delivery of siRNA (Dr. Adam Bohr, 2013-2015) in collaboration with Universite Paris-Sud, France

PhD projects supervised

• Investigation of the formulation, characteristics and performance of micro drug particles intended for oral administration (Adam Bohr, 2011-2013) co-supervision
• Mucosal Delivery of DDA/TDB nanoparticles with Customized Immunostimulatory Properties (Pall Thor Ingvarsson, 2010-2013) co-supervisor
• Molecular level formulation and processing of pharmaceuticals (Jian-Xiong Wu, 2010-2013) co-supervisor

Undervisnings- og vejledningsområder

• Bachelor courses: F24-1 Lægemiddelfremstilling (Pharmaceutical manufacturing, lectures); F24-2 Lægemiddelfremstilling (pharmceutical manufacturing, lab exercises); F24-3 Bachelor project
• Master courses: FFKKA9051 Advanced Manufacturing of Pharmaceuticals; FFKKA9061 Advanced Drug Delivery; FFKKA9071 Pharmaceutical Formulation of Peptides and Proteins; FLVKA0331 Pharmaceutics and Drug Development; FLVKA0341 Research Project in Pharmaceutics and Drug Delivery; FLVKB0391 Drug Discovery and Development
• Course leader for FLVKA0331 Pharmaceutics and Drug Development (master course)

Master students supervised

2013

• Preparation of Solid Lipid Microparticles using Electrospray: A Quality-by-Design Approach (Muhammad Salahuddin bin Haris @ Harith)

2012

• Formulation and Solidification of Nanostructured Lipid Carriers (NLC) using Spray-Drying (Neha Shrestha)
• Amorphous content of budesonide as function of particle size from the spray-drying process (Tatjana Nielsen)
• Correlation between intrinsic viscosity of PVP and particle properties of spray-dried products (Ana Apat)
• Correlation between intrinsic viscosity of polyvinyle acetate and particle properties of spray-dried solid dispersions (Špela Zakšek)
• Oral Delivery of Fenofibrate-loaded Lipid Matrix Particles (Nrupa Borkar)

2011

• Spray Dried Powders for Pulmonary Delivery: A Comparative Study of Methods for Particle Size Determination (Matias Rosenkvist)

2010

• Polymorphism as a function of particle size from the spray-drying process (Yan-Ying Lee)

2009

• Application of the Next generation pharmaceutical impactor to determination of fine particle characteristics of spray-dried powder for inhalation (Lucas Clerdent)
• Spray drying of carbohydrate and characterization of particle properties of the spray-dried powder (Arnaud Baldinger)

CV

Adjunct Professor, Shenyang Pharmaceutical University, China, 2015 -

Associate Professor, Department of Pharmacy, School of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, 2012 -

Associate Professor, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, 2009 - 2012

Research Scientist, Novo Nordisk A/S, Denmark, 2006 - 2009

Postdoctoral Researcher, Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Denmark, 2005 - 2006

Postdoctoral Researcher, Gifu Pharmaceutical University, Japan, 2003 - 2005

Ph.D. (Pharmaceutics), Shenyang Pharmaceutical University, China, 2003

Research and teaching assistant, Yanbian Medical College, Yanbian University, China 1997 - 1999

MSc, Yanbian Medical College, Yanbian University, China 1997

BSc, Yanbian Medical College, Yanbian University, China 1994