Morten Scheibye-Knudsen

2020

Mitophagy and Neuroprotection

Lou, G., Palikaras, K., Lautrup, S., Scheibye-Knudsen, M., Tavernarakis, N. & Fang, E. F., Jan 2020, In: Trends in Molecular Medicine.

Research output: Contribution to journal › Review › peer-review

64 Citations (Scopus)

2019

A defined human aging phenome

Andreassen, S. N., Ezra, M. B. & Scheibye-Knudsen, M., 2019, In: Aging. 11, 15, p. 5786-5806 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

48 Downloads (Pure)

Artificial intelligence for aging and longevity research: Recent advances and perspectives

Zhavoronkov, A., Mamoshina, P., Vanhaelen, Q., Scheibye-Knudsen, M., Moskalev, A. & Aliper, A., 2019, In: Ageing Research Reviews. 49, p. 49-66 18 p.

Research output: Contribution to journal › Review › peer-review

31 Citations (Scopus)

302 Downloads (Pure)

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

Mamoshina, P., Kochetov, K., Cortese, F., Kovalchuk, A., Aliper, A., Putin, E., Scheibye-Knudsen, M., Cantor, C. R., Skjodt, N. M., Kovalchuk, O. & Zhavoronkov, A., 2019, In: Scientific Reports. 9, 10 p., 142.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

59 Downloads (Pure)

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

Fang, E. F., Froetscher, L., Scheibye-Knudsen, M., Bohr, V. A., Wong, J. H. & Ng, T. B., 2019, In: Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Keijzers, G., Bakula, D., Petr, M. A., Madsen, N. G. K., Teklu, A., Mkrtchyan, G., Osborne, B. & Scheibye-Knudsen, M., 2019, In: International Journal of Molecular Sciences. 20, 1, 15 p., 74.

Research output: Contribution to journal › Review › peer-review

13 Citations (Scopus)

59 Downloads (Pure)

Lamin A/C promotes DNA base excision repair

Maynard, S., Keijzers, G., Akbari, M., Ezra, M. B., Hall, A., Morevati, M., Scheibye-Knudsen, M., Gonzalo, S., Bartek, J. & Bohr, V. A., 16 Dec 2019, In: Nucleic Acids Research.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

2018

Aging and drug discovery

Bakula, D., Aliper, A. M., Mamoshina, P., Petr, M. A., Teklu, A., Baur, J. A., Campisi, J., Ewald, C. Y., Georgievskaya, A., Gladyshev, V. N., Kovalchuk, O., Lamming, D. W., Luijsterburg, M. S., Martín-Montalvo, A., Maudsley, S., Mkrtchyan, G. V., Moskalev, A., Jay Olshansky, S., Ozerov, I. V., Pickett, A., & 3 othersRistow, M., Zhavoronkov, A. & Scheibye-Knudsen, M., 2018, In: Aging. 10, 11, p. 3079-3088 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

45 Downloads (Pure)

Monogenic Diseases of DNA Repair

Keijzers, G., Bakula, D. & Scheibye-Knudsen, M., 1 Feb 2018, In: The New England Journal of Medicine. 378, 5, p. 491-492 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

1 Citation (Scopus)

Population specific biomarkers of human aging: A big data study using South Korean, Canadian, and Eastern European patient populations

Mamoshina, P., Kochetov, K., Putin, E., Cortese, F., Aliper, A., Lee, W. S., Ahn, S. M., Uhn, L., Skjodt, N., Kovalchuk, O., Scheibye-Knudsen, M. & Zhavoronkov, A., 2018, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 11, p. 1482-1490 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

57 Downloads (Pure)

Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., Izumchenko, E., & 10 othersde Magalhães, J. P., Artemov, A. V., Costes, S. V., Beheshti, A., Mao, X. W., Pecaut, M. J., Kaminskiy, D., Ozerov, I. V., Scheibye-Knudsen, M. & Zhavoronkov, A., 2018, In: OncoTarget. 9, 18, p. 14692-14722 31 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

70 Downloads (Pure)

2017

Cockayne syndrome: Clinical features, model systems and pathways

Karikkineth, A. C., Scheibye-Knudsen, M., Fivenson, E., Croteau, D. L. & Bohr, V. A., 1 Jan 2017, In: Ageing Research Reviews. 33, p. 3-17

Research output: Contribution to journal › Review › peer-review

97 Citations (Scopus)

Mitophagy in neurodegeneration and aging

Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, M., Stevnsner, T., Nilsen, H., Bohr, V. A. & Fang, E. F., Oct 2017, In: Neurochemistry International. 109, p. 202-209

Research output: Contribution to journal › Review › peer-review

123 Citations (Scopus)

Monogenic diseases of DNA repair

Keijzers, G., Bakula, D. & Scheibye-Knudsen, M., Nov 2017, In: New England Journal of Medicine. 377, 19, p. 1868-1876 9 p.

Research output: Contribution to journal › Review › peer-review

24 Citations (Scopus)

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, M., Mattson, M. P., Nilsen, H., Bohr, V. A. & Becker, K. G., 11 Apr 2017, In: Scientific Reports. 7, 46208.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

102 Downloads (Pure)

2016

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

Marosi, K., Kim, S. W., Moehl, K., Scheibye-Knudsen, M., Cheng, A., Cutler, R., Camandola, S. & Mattson, M. P., 1 Dec 2016, In: Journal of Neurochemistry. 139, 5, p. 769-781 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

92 Citations (Scopus)

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, M., Gjedde, A., Klungland, A., Bohr, V. A., Storm-Mathisen, J. & Bergersen, L. H., 1 Dec 2016, In: Neurobiology of Aging. 48, p. 34-47

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J., & 2 othersGorospe, M. & Bohr, V. A., 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., Gonzalez-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Buron, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., & 27 othersBroeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & de Cabo, R., 14 Jun 2016, In: Cell Metabolism. 23, 6, p. 1093-1112

Research output: Contribution to journal › Journal article › Research › peer-review

174 Citations (Scopus)

NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., & 2 othersNilsen, H. & Bohr, V. A., 11 Oct 2016, In: Cell Metabolism. 24, 4, p. 566-581 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

198 Citations (Scopus)

Neurodegeneration in accelerated aging

Scheibye-Knudsen, M., 2016, 190 p.

Research output: Book/Report › Doctoral thesis

Neurodegeneration in Accelerated Aging

Scheibye-Knudsen, M., Nov 2016, In: Danish Medical Journal. 63, 11, 21 p., B5308.

Research output: Contribution to journal › Review › peer-review

10 Citations (Scopus)

Nuclear DNA damage signalling to mitochondria in ageing

Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, V. A., 22 Apr 2016, In: Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

167 Citations (Scopus)

2015

Animal models of aging research: implications for human aging and age-related diseases

Mitchell, S. J., Scheibye-Knudsen, M., Longo, D. L. & de Cabo, R., 1 Feb 2015, In: Annual Review of Animal Biosciences. 3, p. 283-303 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, M., Bohr, V. A. & Dela, F., 1 Sept 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

A research agenda for aging in China in the 21st century

Fang, E. F., Scheibye-Knudsen, M., Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, V. A., Chan, W. Y., Liu, Y. & Ng, T. B., 1 Nov 2015, In: Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.

Research output: Contribution to journal › Review › peer-review

130 Citations (Scopus)

DNA Damage, DNA Repair, Aging, and Neurodegeneration

Maynard, S., Fang, E. F., Scheibye-Knudsen, M., Croteau, D. L. & Bohr, V. A., Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.

Research output: Contribution to journal › Journal article › Research › peer-review

129 Citations (Scopus)

Loss of NEIL1 causes defects in olfactory function in mice

Canugovi, C., Misiak, M., Scheibye-Knudsen, M., Croteau, D. L., Mattson, M. P. & Bohr, V. A., 1 Feb 2015, In: Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Nourishing the aging brain

Scheibye-Knudsen, M., 1 Mar 2015, In: The Scientist. 29, 3

Research output: Contribution to journal › Journal article › Communication

Protecting the mitochondrial powerhouse

Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, V. A., 1 Mar 2015, In: Trends in Cell Biology. 25, 3, p. 158-170 13 p.

Research output: Contribution to journal › Review › peer-review

156 Citations (Scopus)

2014

A high-fat diet and NAD⁺ activate sirt1 to rescue premature aging in cockayne syndrome

Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, L. H., Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L., & 2 othersDe Cabo, R. & Bohr, V. A., 4 Nov 2014, In: Cell Metabolism. 20, 5, p. 840-855 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

177 Citations (Scopus)

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L. & Bohr, V. A., 2014, In: Autophagy. 10, 8, p. 1468-1469 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis

Li, X., Fang, E. F., Scheibye-Knudsen, M., Cui, H., Qiu, L., Li, J., He, Y., Huang, J., Bohr, V. A., Ng, T. B. & Guo, H., 2014, In: Scientific Reports. 4, 6434.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

Mercken, E. M., Mitchell, S. J., Martin-Montalvo, A., Minor, R. K., Almeida, M., Gomes, A. P., Scheibye-Knudsen, M., Palacios, H. H., Licata, J. J., Zhang, Y., Becker, K. G., Khraiwesh, H., González-Reyes, J. A., Villalba, J. M., Baur, J. A., Elliott, P., Westphal, C., Vlasuk, G. P., Ellis, J. L., Sinclair, D. A., & 2 othersBernier, M. & de Cabo, R., 1 Oct 2014, In: Aging Cell. 13, 5, p. 787-796 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

139 Citations (Scopus)

Morten Scheibye-Knudsen

Research output

Search results