Aging and drug discovery

Daniela Bakula; Alexander M. Aliper; Polina Mamoshina; Michael A. Petr; Amanuel Teklu; Joseph A. Baur; Judith Campisi; Collin Y. Ewald; Anastasia Georgievskaya; Vadim N. Gladyshev; Olga Kovalchuk; Dudley W. Lamming; Martijn S. Luijsterburg; Alejandro Martín-Montalvo; Stuart Maudsley; Garik V. Mkrtchyan; Alexey Moskalev; S. Jay Olshansky; Ivan V. Ozerov; Alexander Pickett; Michael Ristow; Alex Zhavoronkov; Morten Scheibye-Knudsen

doi:10.18632/aging.101646

Aging and drug discovery

Daniela Bakula, Alexander M. Aliper, Polina Mamoshina, Michael A. Petr, Amanuel Teklu, Joseph A. Baur, Judith Campisi, Collin Y. Ewald, Anastasia Georgievskaya, Vadim N. Gladyshev, Olga Kovalchuk, Dudley W. Lamming, Martijn S. Luijsterburg, Alejandro Martín-Montalvo, Stuart Maudsley, Garik V. Mkrtchyan, Alexey Moskalev, S. Jay Olshansky, Ivan V. Ozerov, Alexander PickettMichael Ristow, Alex Zhavoronkov, Morten Scheibye-Knudsen^*

^*Corresponding author for this work

10 Citations (Scopus)

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Abstract

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

Original language	English
Journal	Aging
Volume	10
Issue number	11
Pages (from-to)	3079-3088
Number of pages	10
ISSN	1945-4589
DOIs	https://doi.org/10.18632/aging.101646
Publication status	Published - 2018

Keywords

Aging
Drug discovery

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Aging and drug discoveryFinal published version, 362 KBLicence: CC BY

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Bakula, D., Aliper, A. M., Mamoshina, P., Petr, M. A., Teklu, A., Baur, J. A., Campisi, J., Ewald, C. Y., Georgievskaya, A., Gladyshev, V. N., Kovalchuk, O., Lamming, D. W., Luijsterburg, M. S., Martín-Montalvo, A., Maudsley, S., Mkrtchyan, G. V., Moskalev, A., Jay Olshansky, S., Ozerov, I. V., ... Scheibye-Knudsen, M. (2018). Aging and drug discovery. Aging, 10(11), 3079-3088. https://doi.org/10.18632/aging.101646

Bakula, D, Aliper, AM, Mamoshina, P, Petr, MA , Teklu, A, Baur, JA, Campisi, J, Ewald, CY, Georgievskaya, A, Gladyshev, VN, Kovalchuk, O, Lamming, DW, Luijsterburg, MS, Martín-Montalvo, A, Maudsley, S, Mkrtchyan, GV, Moskalev, A, Jay Olshansky, S, Ozerov, IV, Pickett, A, Ristow, M, Zhavoronkov, A & Scheibye-Knudsen, M 2018, 'Aging and drug discovery', Aging, vol. 10, no. 11, pp. 3079-3088. https://doi.org/10.18632/aging.101646

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abstract = "Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.",

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T1 - Aging and drug discovery

AU - Bakula, Daniela

AU - Aliper, Alexander M.

AU - Mamoshina, Polina

AU - Petr, Michael A.

AU - Teklu, Amanuel

AU - Baur, Joseph A.

AU - Campisi, Judith

AU - Ewald, Collin Y.

AU - Georgievskaya, Anastasia

AU - Gladyshev, Vadim N.

AU - Kovalchuk, Olga

AU - Lamming, Dudley W.

AU - Luijsterburg, Martijn S.

AU - Martín-Montalvo, Alejandro

AU - Maudsley, Stuart

AU - Mkrtchyan, Garik V.

AU - Moskalev, Alexey

AU - Jay Olshansky, S.

AU - Ozerov, Ivan V.

AU - Pickett, Alexander

AU - Ristow, Michael

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

PY - 2018

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AB - Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

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KW - Drug discovery

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DO - 10.18632/aging.101646

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SN - 1945-4589

VL - 10

SP - 3079

EP - 3088

JO - Aging

JF - Aging

IS - 11

ER -

Aging and drug discovery

Abstract

Keywords

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