Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Franco Cortese; Dmitry Klokov; Andreyan Osipov; Jakub Stefaniak; Alexey Moskalev; Jane Schastnaya; Charles Cantor; Alexander Aliper; Polina Mamoshina; Igor Ushakov; Alex Sapetsky; Quentin Vanhaelen; Irina Alchinova; Mikhail Karganov; Olga Kovalchuk; Ruth Wilkins; Andrey Shtemberg; Marjan Moreels; Sarah Baatout; Evgeny Izumchenko; João Pedro de Magalhães; Artem V. Artemov; Sylvain V. Costes; Afshin Beheshti; Xiao Wen Mao; Michael J. Pecaut; Dmitry Kaminskiy; Ivan V. Ozerov; Morten Scheibye-Knudsen; Alex Zhavoronkov

doi:10.18632/oncotarget.24461

Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Franco Cortese, Dmitry Klokov, Andreyan Osipov, Jakub Stefaniak, Alexey Moskalev, Jane Schastnaya, Charles Cantor, Alexander Aliper, Polina Mamoshina, Igor Ushakov, Alex Sapetsky, Quentin Vanhaelen, Irina Alchinova, Mikhail Karganov, Olga Kovalchuk, Ruth Wilkins, Andrey Shtemberg, Marjan Moreels, Sarah Baatout, Evgeny IzumchenkoJoão Pedro de Magalhães, Artem V. Artemov, Sylvain V. Costes, Afshin Beheshti, Xiao Wen Mao, Michael J. Pecaut, Dmitry Kaminskiy, Ivan V. Ozerov^*, Morten Scheibye-Knudsen, Alex Zhavoronkov

^*Corresponding author for this work

32 Citations (Scopus)

70 Downloads (Pure)

Abstract

While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

Original language	English
Journal	OncoTarget
Volume	9
Issue number	18
Pages (from-to)	14692-14722
Number of pages	31
ISSN	1949-2553
DOIs	https://doi.org/10.18632/oncotarget.24461
Publication status	Published - 2018

Keywords

DNA damage
Longevity
Mars mission
Radioresistance
Space exploration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.24461Licence: CC BY

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonizationFinal published version, 3.43 MBLicence: CC BY

Cite this

Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., ... Zhavoronkov, A. (2018). Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. OncoTarget, 9(18), 14692-14722. https://doi.org/10.18632/oncotarget.24461

Cortese, F, Klokov, D, Osipov, A, Stefaniak, J, Moskalev, A, Schastnaya, J, Cantor, C, Aliper, A, Mamoshina, P, Ushakov, I, Sapetsky, A, Vanhaelen, Q, Alchinova, I, Karganov, M, Kovalchuk, O, Wilkins, R, Shtemberg, A, Moreels, M, Baatout, S, Izumchenko, E, de Magalhães, JP, Artemov, AV, Costes, SV, Beheshti, A, Mao, XW, Pecaut, MJ, Kaminskiy, D, Ozerov, IV, Scheibye-Knudsen, M & Zhavoronkov, A 2018, 'Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization', OncoTarget, vol. 9, no. 18, pp. 14692-14722. https://doi.org/10.18632/oncotarget.24461

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abstract = "While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.",

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AU - Osipov, Andreyan

AU - Stefaniak, Jakub

AU - Moskalev, Alexey

AU - Schastnaya, Jane

AU - Cantor, Charles

AU - Aliper, Alexander

AU - Mamoshina, Polina

AU - Ushakov, Igor

AU - Sapetsky, Alex

AU - Vanhaelen, Quentin

AU - Alchinova, Irina

AU - Karganov, Mikhail

AU - Kovalchuk, Olga

AU - Wilkins, Ruth

AU - Shtemberg, Andrey

AU - Moreels, Marjan

AU - Baatout, Sarah

AU - Izumchenko, Evgeny

AU - de Magalhães, João Pedro

AU - Artemov, Artem V.

AU - Costes, Sylvain V.

AU - Beheshti, Afshin

AU - Mao, Xiao Wen

AU - Pecaut, Michael J.

AU - Kaminskiy, Dmitry

AU - Ozerov, Ivan V.

AU - Scheibye-Knudsen, Morten

AU - Zhavoronkov, Alex

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