Nuclear DNA damage signalling to mitochondria in ageing

TY - JOUR

T1 - Nuclear DNA damage signalling to mitochondria in ageing

AU - Fang, Evandro Fei

AU - Scheibye-Knudsen, Morten

AU - Chua, Katrin F

AU - Mattson, Mark P

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

PY - 2016/4/22

Y1 - 2016/4/22

N2 - Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

AB - Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

U2 - 10.1038/nrm.2016.14

DO - 10.1038/nrm.2016.14

M3 - Journal article

C2 - 26956196

SN - 1471-0072

VL - 17

SP - 308

EP - 321

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 5

ER -